The Drs. Eades & Julia…and radio

I have to confess.  I lied to you.  I said the next post would be part II of the Meat Eater or Vegetarian series and here I am sticking another one in in between.  But I at least have a good reason for this interloper post: it is time sensitive.

Due to other commitments tomorrow and Monday (see below for the Monday commitment) I more than likely won’t be able to get the promised post up before Tuesday.  I was working away on it this afternoon (actually alternating between writing the post and dealing with comments) when my bride came in and whined for me to go to a movie I didn’t really want to see.  But, being the dutiful and obliging spouse that I am, I went.  And I was glad I did.

MD just finished the book Julie & Julia and was hot to see the movie.  I hadn’t read the book, and don’t plan on it, so I was lukewarm at best on the idea.  But I’m glad I relented because the movie is one of the best I’ve seen in a long while.  MD and I related to it on a number of levels.  We written books and have been through all the publisher snafus that Julia experienced.  We know what it’s like to have a cooking show.  And we’ve been through the blogging experience.  But, unlike the heroine of the blog and book, we’ve actually met Julia.

In the summer of 2000, a couple of friends of ours who own Al Forno, a famous restaurant in Providence, RI, arranged for MD and me to be a part of a huge fundraiser for the Providence Public Library.  It got worked out in such a way that MD and I attended as – get this – celebrity chefs.  Chefs? I still don’t know how it happened because our cooking show hadn’t even been conceived of at that time and we had just published The Protein Power LifePlan a few months earlier.  But there we were as celebrity chefs with – get this, too – Emeril Lagasse, Jacques Pepin, and Julia Child.  And, as they say, that’s not all.  We were there with Billy Joel as well.  Yep, Billie, Emeril, Jacques, Julia, MD and me – the celebs brought out to raise money for the Providence Public Library.  It was kind of surreal.

When I was introduced to Julia, I told her I was delighted to meet her and that my wife and I lived in her home town.  I knew she lived in Santa Barbara, and MD and I had been living there for about a year at the time – if you could call it living there.  We actually lived primarily in Incline Village, Nevada and Santa Fe, New Mexico, but we did spent a fair amount of time in Santa Barbara, where we lived aboard a sailboat in the marina when we were in town.  So, I was more or less honest when I said we lived in Santa Barbara.

Julia Child was a big woman.  And I don’t mean fat, I mean big.  She’s well over six feet tall and is imposing even stooped a bit as she was then at age almost 90.  As we shook hands she replied to my remark about living in her home town in her wonderful, warble-y, quivery voice, “Which home town? Santa Barbara or Cambridge, Massachusetts?”  And she moved when she spoke just as Meryl Streep portrays her in the movie.

Until that moment, I hadn’t realize she lived anywhere but Santa Barbara, but it just so happened that MD and I had just purchased a condo in Cambridge a few months before.  Our eldest son, wife and first grandchild were moving to the Boston area for a year while our son clerked with a federal judge.  We bought the condo and they rented it from us.  So, I answered her that we lived both places.  Which, of course, was a stretch since we lived part time on a boat in one and owned a rental condo in the other, but, hey, I was among real celebrities so I had to act the part.

In the years between that first meeting and her death, we saw her a dozen or so times around Santa Barbara.  She frequented a lot of the same restaurants we did and was a regular at the farmer’s market.  But other than the time we chatted a bit at the Providence Library shindig, neither MD nor I ever spoke with her again.  We would say hello if we passed one another, but that’s it.  I’m sure she didn’t have a clue we had met before.  Having had the interaction with her that we did, made the movie a little more poignant for us.  I now wish we had made the effort to get to know her while we had the chance.

Julia had to deal with her publisher and with promoting her various books.  And we do too.  One of the things authors agree to when they sign a publishing contract is to make themselves available for various publicity events.  MD and I have done the book tour routine (which is miserable), appeared on countless TV shows and radio shows, and shown up for innumerable book signings.   None of these PR events are particularly fun, but the most loathsome PR event of all takes place this coming Monday.  It is the dreaded radio satellite tour.

There is a certain type of PR agent that books these kinds of things, which involve scheduling numerous radio shows one right after the other with military precision.  The shows start on drive time radio on the East Coast and move west with the sun.

We will start at 6:50 AM Eastern, which is 3:50 AM our time, and be on the radio pretty much non-stop throughout the day.  A number of you have asked in the comments if we are going to be appearing anywhere.  Right now, this is all that is scheduled.  I’ve posted the schedule below so that if we’re on a station in your neck of the woods, you’ll be able to listen should you chose to.

It will be a grueling day for us, but somehow we’ll manage to keep our good cheer through it all.  A thousand cups of coffee will help.  Hope you get to listen in to part of it.

MAM pg 1

ABC’s big meal propaganda

Applebee's Quesadilla Burger

Applebee's Quesadilla Burger

One of my readers sent me a link to a segment on ABC News with Charlie Gibson showing just how disgustingly slanted and inaccurate mainstream media reports can be.

Gibson leads into the segment about two reporters who underwent self experimentation on the adverse effects of unhealthy eating.  The reporters, ABC’s Yuji de Nies and Jon Garcia, set out to see what would happen if they consumed a giant meal containing over 6,000 calories.  Here is the result as they reported it.

Pretty brutal, eh?  But let’s shine the piercing light of good sense on what is going on here.  As you might expect, the reality is vastly different from that portrayed by ABC.

First off, let’s look at the actual nutritional content of the food eaten.  As reported in the piece, the total energy content of the meal was 6,190 calories, which included 187 grams of saturated fat.  These were the only parameters reported.  I took the time to go through the links in the article accompanying the video to find exactly where these foods came from.  Here’s what I found.

The burger is an Applebee’s Quesadilla Burger (served with fries, of course); the snack is The Cheesecake Factory Fried Macaroni And Cheese; and the dessert is Uno Chicago Grill Mega-sized Deep Dish Sundae (listed as cookie below).  How do I know these are the exact ones?  These were the ones referenced in the CSPI’s List of Most Unhealthy High-Calorie, Fat and Salty Restaurant Foods That May Clog Your Arteries.  After seeing the photos and comparing to what I saw on the video, these selections are the ones the reporters ate.

I then tracked down the Nutritional Facts for the foods involved (here, here, here and here) and put them into an Excel spreadsheet.  Take a look.

ABC calorie count1

The first thing you might notice is that the total calorie count is 5,708, which is considerable, but is actually 482 calories fewer than the 6,190 reported.  Second, and this is a biggie, the saturated fat content of this meal is only 88 grams, not the 187 grams reported.

The reporters stretched the truth a little in that they reported as if the Mega-sized Deep Dish Sundae were a single treat to be consumed by one person at a sitting.  I’m sure it could be so eaten, but it’s actually designed for four people to share.  The Nutritional Facts list the calories per serving as 690 and the saturated fat as 17 grams.  I’ve used the amounts in all four servings, i.e., one entire four-person dessert, in my spreadsheet.

As you may have noticed, the total carb content of the meal is 745 grams, which converts during digestion to a little over three cups (3.1 cups to be exact) of sugar.  The ABC report, of course, failed to mention the carb content of the meal and ignored any immediate effect this huge intake of carb might cause.  One of the reporters, Jon, claimed that he was ‘sluggish’ and ‘tired’; the implication being that this sluggishness resulted from his huge saturated fat intake.  No mention, naturally, of the enormous amount of carbohydrate and the large increase in insulin release it might cause.  From what I can see from the video, Jon looks to be sporting a little abdominal obesity, which would imply a degree of insulin resistance and hyperinsulinemia.  People with this disorder tend to over secrete insulin in response to carb intake causing an overshoot and reactive hypoglycemia (low blood sugar), which will indeed result in sluggishness.

It’s pretty impressive when the lab tech holds up the tube of blood taken after the meal and compares it to the one taken before the meal.  There is a lot of fat swimming in the serum, that’s for sure.  What the producers of this piece (and, sadly, the doctors commenting although they should know better) want you to take away from all this by the way they set it up is that all that saturated fat went directly into the blood.  And how can you argue with them?  It’s there for all to see.

Problem is, that’s what blood samples look like after almost any meal, especially one that contains carbohydrates.  The fat you see isn’t the fat the two reporters ate; it is the fat the liver has made from the carbohydrate.  It’s the same picture a tube of blood would show after either of the two doctors had eaten a high-carb, low-fat lunch.

The blood samples were taken two hours after the meal.  Dietary carbohydrate is absorbed directly into the blood and makes a pass through the liver where it stimulates the production of triglycerides, the fat you see in the blood.  Fat, especially long-chain saturated fat digests very slowly, and doesn’t reach the blood until much later than the two hour mark.  While carbs go directly into the blood, fats take a different route.  The process that breaks down dietary fat into its component fatty acids is a lengthy process as compared to the breakdown of carbs.  Once the fat has broken down, it has to combine with bile salts to make it into a form that is water soluble and can be taken up by the intestinal cells.  Once taken up, unlike carbs, which are sent directly to the bloodstream, fats go into the lymphatic system, a much smaller and more static transport system than the vasculature.  Once in the lymphatics, fats make their way to the thoracic duct, which empties into a large vein in the upper chest.  The lymphatics are small vessels and take a long time to move their contents along since there is no heartbeat pushing them as there is with blood.  As I say, the fat in the blood you see on the video didn’t come from the saturated fat in the diet, although that was definitely the implication.

But what about the ultrasound showing the blood vessels had changed?  Wasn’t that because of the fat?

I’m afraid not.  The fat from the diet wasn’t in the blood vessels yet, so it couldn’t be the dietary fat causing the change.  So what was it?

How about a little normal physiology.  Let me explain.  The body gets blood where it needs to get it by opening certain blood vessels while closing others.  Let me give you an example.  Have you ever jumped into cold water to go swimming and noticed that not long after jumping in you have to urinate?  What happened?

Your arms and legs have a radiator effect.  Since these appendages have little padding the blood circulating there is exposed to the cold water, and if nothing is done, the cold water cools the blood creating a big problem.  Your body compensates by shutting down the circulation to the skin and areas close to the surface in your arms and legs and shunts that blood to your core.  Your core already has plenty of blood when this happens, so it has to get rid of some.  It does so by sending it through the kidneys where the liquid portion is filtered out and becomes urine.  Suddenly your bladder is full and you have to go.

The body has the ability to direct blood wherever it needs by its manipulation of blood vessel size.  Where do you think blood is needed after an almost 6,000 calorie meal?  That’s right.  The digestive tract.  It takes a lot of work to deal with 6,000 calories, and a lot of work requires a lot of oxygen, which comes from the blood.  So after a heavy meal, the body shunts extra blood to the guts where the works is being done.  It does this by opening or dilating the arteries carrying blood to the intestines and by narrowing the blood vessels in other parts of the body.

Now, think back to the video of the woman whose blood vessel (in her arm) is being examined by ultrasound.  When it’s compared to the previous ultrasound, the one before she ate, notice how much faster the heart is beating.  (The little swishing sounds you hear, each of which represents a heart beat, are spaced much closer together.)  The heart is beating faster because the body is working to digest an enormous amount of food, and this work stresses the heart in the same way that running down the street would stress the heart.  Work is work.

The digestive tract needs extra oxygen to do its work, this extra oxygen can get there only via the blood, so the intestines require more blood than normal.  This extra blood gets shunted there by opening the arteries that feed the gut and narrowing those that go other places where a lot of blood isn’t needed at the moment.  Such places as, say, a relaxed arm.

Anyone with a smattering of knowledge of normal physiology (and apparently an open mind) could predict that the artery in a relaxed arm would narrow after a heavy meal and that that artery would be back to normal six hours later (which it was so reported in this video).

What you’re seeing in this video is normal physiology at work interpreted as being abnormal by a couple of lipophobic doctors who should (and probably do) know better.  It makes for dramatic theater, but their interpretation is nothing but prevarication or ignorance or both.

But had they reported the truth, there would have been no story.  Kind of sad, isn’t it.

Vitamin D and influenza

Image credit: Nature Reviews Cancer

Image credit: Nature Reviews Cancer

The latest newsletter from Dr. Cannell, President of the Vitamin D Council, on vitamin D and the swine flu (and influenza in general).  Well worth reading.

If you are interested in a free subscription to this newsletter, go to the Vitamin D Council site and sign up.

John Cannell, MD
Vitamin D Council Newsletter
May 16, 2009

I have received hundreds of emails from readers, asking what they should do about the possibility of an H1N1 flu pandemic.

Dear Dr. Cannell:

1.    Should I take Vitamin D to prevent the H1N1 flu?  If so, how much?

2.    What role did Vitamin D play in the 1918 pandemic?

3.    If I get this flu, should I take very high doses of vitamin D?  Is so, how much?

4.    Should I take the special flu vaccine the CDC and others are developing?

5.    What are you going to do for your family about the 2009 flu?

6.    Why do the CDC and NIH ignore the Vitamin D studies?

The Public, USA

Dear Public:

First read what I have written about influenza.  Both papers can be downloaded and printed out in their entirety:

Cannell JJ, Zasloff M, Garland CF, Scragg R, Giovannucci E.  On the epidemiology of influenza. Virol J. 2008 Feb 25;5:29.

Cannell JJ, Vieth R, Umhau JC, Holick MF, Grant WB, Madronich S, Garland CF, Giovannucci E.  Epidemic influenza and vitamin D. Epidemiol Infect. 2006 Dec;134(6):1129-40.

My short executive answers:

1)    Take enough Vitamin D3 to get your 25(OH)D level above substrate starvation levels (50 ng/ml or 125 nmol/L).  Levels of 50 ng/ml usually require at least 5,000 IU per day for adults, some adults will require more.  Children should take 1,000 IU per every 25 pounds of body weight.  After taking this dose for 3 months have a 25(OH)D level.  Individual variation in dose response is great and natural 25(OH)D levels (50-70 ng/ml) are not assured by these doses.  For reasons I will discuss below, I think it possible that Vitamin D levels of 30 ng/ml, which are often obtained by people taking low doses of Vitamin D (1,000 to 2,000 IU/day), may increase your risk of death from a 1918-like influenza virus.

2)    It is clear to me that Vitamin D did not play a controlling role in 1918.  The lethality of the 1918 virus easily overwhelmed innate immunity although I am unwilling to impair my innate immunity by taking inadequate doses of Vitamin D.

3)    Stock you homes pharmacy with several fresh bottles of 50,000 IU capsules of Vitamin D3,  a medicine, not a supplement, and if you get this flu, take 2,000 IU per kg of body weight per day for a week.  As I weigh 220 pounds, I would take 200,000 IU per day for seven days if I thought I had an infection with a 1918-like influenza virus.

4)  Get the H1N1 flu shot as soon as it is available in the fall, especially if the virus shows evidence of lethality this summer in the southern hemisphere,  For reasons I will discuss, a flu shot probably will not generate an immune response in people with 25(OH)D levels above 50 ng/ml but that is simply conjecture.  That is, the flu shot may not work, may not generate antibodies, in people with 25(OH)D levels above 50 ng/ml.  In my opinion, the risk of a lethal virus is higher than the risk of Guillain-Barré Syndrome.  In fact, the risk of Guillain-Barré Syndrome is probably the highest in non-vaccinated people who are infected with the virus and quite low in those who take a modern flu vaccine.

5)   Besides the above actions, stock up on TamiFlu in your home medicine cabinet so you have it next fall and winter.  And follow common-sense precautions, especially frequent hand washing.

6)   Most medically trained physicians, scientists or practitioners think in terms of something bad causing illness, not something good preventing it.  Ask any physician what George Bernard Shaw meant when he said, the characteristic microbe of a disease might be a symptom instead of a cause.  The idea that seasonal influenza or the common cold is a symptom, even the presence of the virus itself being a symptom of an underlying condition, is foreign to modern medical thought.  Influenza researchers at the CDC and NIH think only in terms of vaccines and anti-virals, mainly because most of them have such strong economic affiliations with some aspect of the influenza industry.  The idea of diagnosing and treating Vitamin D deficiency as one part of influenza preparedness is simply foreign to them. Unfortunately, their attitude contributes to the 36,000 deaths every year in the USA from seasonal influenza and leaves American’s innate immune system naked in facing a pandemic.

Detailed answers:

Again, for me to fully answer your questions, and for you to understand my reasoning, the first thing you need to do is to read the articles I have written about influenza.  Neither article is about pandemic influenza, rather epidemic influenza.  Both are full access articles.

Cannell JJ, Zasloff M, Garland CF, Scragg R, Giovannucci E.  On the epidemiology of influenza. Virol J. 2008 Feb 25;5:29.

Cannell JJ, Vieth R, Umhau JC, Holick MF, Grant WB, Madronich S, Garland CF, Giovannucci E.  Epidemic influenza and vitamin D. Epidemiol Infect. 2006 Dec;134(6):1129-40.

Next is to read additional papers on our website.  We have attempted to get full copies of the most important articles when possible:

Vitamin D Council/Science/Influenza

The WHO reports:

“H1N1 appears to be more contagious than seasonal influenza. The secondary attack rate of seasonal influenza ranges from 5% to 15%. Current estimates of the secondary attack rate of H1N1 range from 22% to 33%.  With the exception of the outbreak in Mexico, which is still not fully understood, the H1N1 virus tends to cause very mild illness in otherwise healthy people. Outside Mexico, nearly all cases of illness, and all deaths, have been detected in people with underlying chronic conditions.

In the two largest and best documented outbreaks to date, in Mexico and the United States, a younger age group has been affected than seen during seasonal epidemics of influenza. Though cases have been confirmed in all age groups, from infants to the elderly, the youth of patients with severe or lethal infections is a striking feature of these early outbreaks.  In terms of population vulnerability, the tendency of the H1N1 virus to cause more severe and lethal infections in people with underlying conditions is of particular concern.”

Virologists are concerned with three aspects of any influenza virus: (1) novelty, (2) transmissibility, (3) lethality.  The current H1N1 is novel, that is, we have no antibodies to this strain.  Its transmissibility is high but its lethality (percent who die after infection) is still low, except in Mexico.  Why it was so lethal in Mexico, no one knows.  Will that lethality return as the virus mutates this summer?  Keep in mind that the lethality of the 1918 flu was high, perhaps a billion people infected, a half billion became ill, and, at the most, one tenth of a billion died.  Until the 2009 virus exposes its lethality, and it may not do so until next fall or winter, we are all playing an involuntary game of Russian roulette.

Pandemics imply widespread infection thus transmissibility, but do not specify the virus’s lethality.  However, this virus was transmitted in May, near the equator, at 7,000 feet altitude.  May is the time influenza transmission usually stops because population 25(OH)D levels are rising quickly. Lethality of influenza viruses change over short periods of time (weeks to months).

That is, the WHO and CDC have no way of knowing if this virus will acquire lethality.  Lethality is how quickly this virus will bore holes in your lung cells, hijack that cells genetic machinery, burst the cell, and spew out hundreds of thousands of swarming viruses to do the same thing to the next respiratory cell, perhaps triggering a cytokine storm response by your body’s immune system that quickly strips your lungs of the cells you need to breath.

If that does not kill you within a few days, it leads to pneumonia, the “Captain of the Men of Death,” who finishes the job in a few weeks.  Some viruses, even novel ones, even novel pandemic ones, are not very lethal.  The 1918 virus was an expert driller and was thus highly lethal, but it was its transmissibility combined with lethality that lead to the massive deaths.  It was able to eventually infect about half the world, maybe more; its combined lethality and transmissibility showed itself during its second wave, the autumn wave of 1918.  The Asian pandemic of 1957 started mild, and returned in a somewhat more severe form the following winter. The 1968 Hong Kong pandemic began relatively mild and remained mild in its second winter wave in most countries.

Dear Dr. Cannell:

How does Vitamin D work in the immune system?

Philip, Texas

Dear Philip:

Two systems exist in your body to fight infections, the innate or immediate system and the acquired or adaptive immune system that makes antibodies.  Recent evidence indicates seasonal impairments of the antimicrobial peptide (AMPs) systems are crucial to impaired innate immunity, impairments caused by seasonal fluctuations in 25-hydroxy-vitamin D [25(OH)D] levels.  The evidence that vitamin D has profound effects on innate immunity is rapidly growing.

Janet Raloff. The Antibiotic Vitamin, Science News

Unlike adaptive immunity, innate immunity is that branch of host defense that is “hard-wired” to respond rapidly to infections using genetically encoded effectors that are ready for activation by an antigen before the body has ever encountered that antigen. Of the effectors, the best studied are the antimicrobial peptides (AMPs).

Both epithelial tissues and white blood cells produce AMPs; they exhibit rapid and broad-spectrum antimicrobial activity against bacteria, fungi, and viruses. In general, they act by rapidly and irreversibly damaging the lipoprotein membranes of microbial targets, including enveloped viruses, like influenza.

Antimicrobial peptides protect mucosal epithelial surfaces by creating a hostile antimicrobial barricade. The epithelia secrete them constitutively into the thin layer of fluid that lies above the apical surface of the epithelium but below the viscous mucous layer. To effectively access the epithelium, a microbe must first infiltrate the mucous barrier and then survive assault by the AMPs present in this fluid. Should microbes breach this constitutive cordon, their binding to the epithelium rapidly mobilizes the expression of high concentrations of specific inducible AMPs, which provide a backup antimicrobial shield.

The crucial role of vitamin D in the innate immune system was discovered only very recently. Both epithelial cells and macrophages increase expression of the antimicrobial cathelicidin upon exposure to microbes, an expression that is dependent upon the presence of vitamin D. Pathogenic microbes stimulate the production of an enzyme that converts 25(OH)D to 1,25(OH)2D, a seco-steroid hormone. This in turn rapidly activates a suite of genes involved in pulmonary defense.

In the macrophage, the presence of vitamin D also appears to suppress the pro-inflammatory cytokines. Thus, vitamin D appears to both enhance the local capacity of the epithelium to produce endogenous antibiotics and at the same time dampen certain destructive arms of the immune response, especially those responsible for the signs and symptoms of acute inflammation, such as the cytokine storms operative when influenza kills quickly.

Because humans obtain most vitamin D from sun exposure and not from diet, a varying percentage of the population is vitamin D deficient, at any time, during any season, at any latitude, although the percentage is higher in the winter, in the aged, in the obese, in the sun-deprived, in the dark-skinned, and in more poleward populations. However, seasonal variation of vitamin D levels even occur around the equator and widespread vitamin D deficiency can occur at equatorial latitudes, probably due to sun avoidance, rainy seasons, and air pollution.

For example, a study of Hong Kong infants showed about half had 25(OH)D levels less than 20 ng/ml in the winter. Even in the summer, few of the infants had levels higher than 30 ng/ml, which many experts now think is well below the lower limit of the optimal range. As 25(OH)D levels affect innate immunity, then a varying percentage of most populations even equatorial ones will have impaired innate immunity at any given time, together with distinct seasonal variations in that percentage. The effects such impairments have on influenza transmission are unknown.

Dear Dr. Cannell:

Will Vitamin D protect me against acquiring the H1N1 flu?

George, Utah

Dear George:

I don’t know; no one does.  I am concerned about people who take low doses of Vitamin D (1,000 – 2,000 IU/day) and only achieve a 25(OH)D blood level of 30 ng/ml.  If the virus mutates into a virus as lethal as the 1918 virus, I doubt Vitamin D will totally protect you. Several facts about the 1918 pandemic concern me.

1. Blacks were less likely to contract the flu or die from the flu than whites in 1918.

2. Young people, presumably with the highest 25(OH)D levels, were the most likely to die in 1918, as they have been in Mexico to date.

3. In October of 1918, the Spanish flu erupted simultaneously in both Northern and southern hemispheres.

4. Significant deaths occurred in the Northern hemisphere during the summer of 1918 although the extraordinary killing erupted in October of 1918 in the Northern Hemisphere.

5. One of the worst affected countries was Western Samoa. A crippling 90% of the population was infected; 30% of adult men, 22% of adult women and 10% of children were killed.  This devastation occurred during their summer.  I doubt 90% of the population of Western Samoa had levels below 50 ng/ml in 1918 but I have no way of knowing.  More likely, the population had little acquired immunity to any influenza virus.

Jordan EO: Epidemic Influenza, a survey. Chicago: American Medical Association; 1927. [you’ll have to follow the links to get to this one]

After rereading Jordan, I doubt vitamin D was the controlling factor in the 1918 Pandemic.  Furthermore, some of the above data – highest death rates in whites and young adults suggests having some vitamin D was a risk factor for death.  Thus, take enough Vitamin D.

However, other facts suggest Vitamin D was protective in 1918:

1. The mass of deaths in the Northern hemisphere occurred when Vitamin D levels were low (fall and winter).

2. While infection rates were similar for sailors and troops on infected troop transport ships, the sailors had 1/4 the mortality of the troops.  One has to assume the 25(OH)D of sailors aboard 1918 troop transport ships was higher than the troops inside.

3. Underground coal miners in North America had the highest mortality of any occupation.

4. The incidence of influenza in the French army was much higher in troops away from the front (probably in barracks) than in front line troops.

5. Open air hospitals in North America allegedly had lower mortalities than regular hospitals.

6. Mortality for sailors at sea was markedly lower than sailors ashore, despite the crowed conditions on board.

7. In the Western Front, the 1918 flu disappeared in August (when 25(OH)D levels reach their peak) only to return in September, when 25(OH)D levels fall rapidly.

My best guess is that 5,000 IU/day and a 25(OH)D of > 50 ng/ml will be at least partially protective.  Remember, at 50 ng/ml, you are assured that you are not suffering from substrate starvation, that is, your body has enough Vitamin D for its needs and some left over to store.  At a level of 30 ng/ml, most people are still suffering from Vitamin D substrate starvation.

Heaney RP, Armas LA, Shary JR, Bell NH, Binkley N, Hollis BW. 25-Hydroxylation of vitamin D3: relation to circulating vitamin D3 under various input conditions. Am J Clin Nutr. 2008 Jun;87(6):1738-42.

As I have written before, 25(OH)D levels are like water from a mountain spring.  The topmost pool is the calcium economy.  When that pool is full, excess 25(OH)D flows down to hundreds of pools below, cancer, heart disease, infection, etc.  In a lethal pandemic, you want Vitamin D to do two things, increase production of natural antibiotics (AMPs) and quell excessive immune responses.  Are these two pools at the same level?  Is the AMP pool above the cytokine dampening pool?  If so, people with 25(OH)D levels of 30 ng/ml may have enough D to strengthen their innate immunity but not enough to prevent the cytokine storm that kills in a lethal pandemic.  Thus, people taking only 1,000 – 2,000 IU/day, with levels around 30 ng/ml, may risk death from a cytokine storm their body is unable to prevent.  While only a theory, it would explain why the people with the allegedly highest 25(OH)D levels in both Mexico and 1918 (young adults) were the most likely to die.  That is why I caution people that, if you are going to take Vitamin D, take enough, take 5,000 IU/day, which is usually enough to get your 25(OH)D levels into the mid range of the reference range (30-100 ng/ml), which would be 50-70 ng/ml.

Dear Dr. Cannell:

Will this H1N1 flu reappear next fall?

May, Washington DC

Dear May:

Million dollar question!  Flu viruses constantly mutate.  Right now it lacks an amino acid sequence that confers lethality.  Will it acquire that amino acid by next fall?  I don’t know and if anyone one tells you they know then you know a fool.

Dear Dr. Cannell:

Will you and your family take the flu shot they are developing?

Jerry, North Carolina.

Dear Jerry:

Yes.

However, it will probably not do much as it may be unable to generate an immune response in those with high 25(OH)D levels.  Two Russian studies, the only such studies in the world, suggest higher vitamin D levels prevent the immune response flu shots attempt to generate.  Dr. Scott Dowell, at the CDC, has known about these two studies for at least five years.

In 1977, Russian scientists inoculated 834 non-immune males with live attenuated influenza virus in St Petersburg (62 N) and Krasnodar (45 N), Russia during different seasons of the year, comparing them to 414 vehicle placebo controls. In St Petersburg, they found that the attenuated virus was about eight times more likely to cause physical evidence of infection (fever) in the winter than the summer (6.7% vs. 0.8%). In Krasnodar, 8% of inoculated subjects developed a fever from the virus in January, but only 0.1% did so in May.

Shadrin AS, Marinich IG, Taros LY. Experimental and epidemiological estimation of seasonal and climatogeographical features of non-specific resistance of the organism to influenza. Journal of Hygiene, Epidemiology, Microbiology, and Immunology 1977; 21: 155161.

Different Russian scientists found that fever after inoculation with attenuated virus was twice as likely in February (10.7%) as in June (5%), compared to vehicle placebo controls. They also confirmed that sero-conversion varied by season, with the lowest rate of antibody formation in summer. When they attempted to recover the virus 4872 h after inoculation, they found subjects were more likely to shed the virus in December (40%) than in September (16%), and the quantity of virus shed was significantly lower in summer than winter.

Zykov MP, Sosunov AV. Vaccination activity of live influenza vaccine in different seasons of the year. Journal of Hygiene, Epidemiology, Microbiology, and Immunology 1987; 31: 453459.

These two studies suggest higher Vitamin D levels may prevent a vaccine from causing an immune response, the whole idea of a vaccine.

Dear Dr. Cannell:

What about Guillain-Barré Syndrome if I take the flu shot?

Jeanne, California

Dear Jeanne:

Influenza or influenza like illness usually precedes the autoimmune process of Guillain-Barré Syndrome.  Thus, a recent study found a seven-fold risk for those who contracted the flu but a slightly decreased risk for those getting a modern vaccine.

Stowe J, Andrews N, Wise L, Miller E. Investigation of the temporal association of Guillain-Barre syndrome with influenza vaccine and influenza-like illness using the United Kingdom General Practice Research Database. Am J Epidemiol. 2009 Feb 1;169(3):382-8.

This appears to be much different than the 1976-77 swine flu experience, the last time a swine flu virus caused this type of consternation.  Then, the vaccine was associated with a seven-fold risk of Guillain-Barré Syndrome, but the feared pandemic never materialized.  That is, as Guillain-Barré Syndrome is a complication of the flu and the flu failed to materialize that year, we will never know what the risk of Guillain-Barré Syndrome would have been in 1978 in those who got the flu but no flu shot.

Safranek TJ, Lawrence DN, Kurland LT, Culver DH, Wiederholt WC, Hayner NS, Osterholm MT, O’Brien P, Hughes JM.  Reassessment of the association between Guillain-Barré syndrome and receipt of swine influenza vaccine in 1976-1977: results of a two-state study. Expert Neurology Group. Am J Epidemiol. 1991 May 1;133(9):940-51.

As Guillain-Barré Syndrome is an autoimmune process, those on 5,000 IU per day should not have to fear it.

Dear Dr. Cannell:

Why does the CDC and WHO ignore all the work on Vitamin D and flu?

Sally, California

Dear Sally:

I’m not sure.  A randomized placebo controlled trial showed vitamin D prevents colds and flu.

Aloia JF, Li-Ng M. Re: epidemic influenza and vitamin D. Epidemiol Infect. 2007 Oct;135(7):1095-6;

However, when these same authors attempted to reproduce their findings by giving 2,000 IU/day for four months, they found no protective effect of Vitamin D.

Li-Ng M, Aloia JF, Pollack S, Cunha BA, Mikhail M, Yeh J, Berbari N. A randomized controlled trial of vitamin D3 supplementation for the prevention of symptomatic upper respiratory tract infections. Epidemiol Infect. 2009 Mar 19:1-9.

However, these same authors have since concluded that 2,000 IU/day for four months is an inadequate dose and 5,000 IU per day is generally required to assure 95% of the population has adequate levels.

Aloia JF, Patel M, Dimaano R, Li-Ng M, Talwar SA, Mikhail M, Pollack S, Yeh JK. Vitamin D intake to attain a desired serum 25-hydroxyvitamin D concentration. Am J Clin Nutr. 2008 Jun;87(6):1952-8.

At least 5 studies show an inverse association between lower respiratory tract infections and 25(OH)D levels or sunshine.  That is, the higher your 25(OH)D level, the fewer colds and flu:

Laaksi I, Ruohola JP, Tuohimaa P, Auvinen A, Haataja R, Pihlajamäki H, Ylikomi T.  An association of serum vitamin D concentrations < 40 nmol/L with acute respiratory tract infection in young Finnish men. Am J Clin Nutr. 2007 Sep;86(3):714-7.

Karatekin G, Kaya A, Salihoğlu O, Balci H, Nuhoğlu A. Association of subclinical vitamin D deficiency in newborns with acute lower respiratory infection and their mothers. Eur J Clin Nutr. 2009 Apr;63(4):473-7.

Ginde AA, Mansbach JM, Camargo CA Jr. Association between serum 25-hydroxy-vitamin D level and upper respiratory tract infection in the Third National Health and Nutrition Examination Survey. Arch Intern Med. 2009 Feb 23;169(4):384-90.

Wayse V, Yousafzai A, Mogale K, Filteau S. Association of subclinical vitamin D deficiency with severe acute lower respiratory infection in Indian children under 5 y. Eur J Clin Nutr. 2004 Apr;58(4):563-7.

Termorshuizen F, Wijga A, Gerritsen J, Neijens HJ, van Loveren H. Exposure to solar ultraviolet radiation and respiratory tract symptoms in 1-year-old children. Photodermatol Photoimmunol Photomed. 2004 Oct;20(5):270-1.

Despite these studies, the scientists at CDC and WHO are thinking only in terms of a vaccine or TamiFlu.  The idea of strengthening the innate immune system with Vitamin D is simply not on their radar.  Many of these scientists have financial connections to the influenza industry.  However, It is not a conspiracy.  When I was young, I thought most things were conspiracies.  Now that I am older, I know it is not a conspiracy, only incompetence.

If this virus mutates this summer and acquires more lethality and maintains its transmissibility, we may experience another 1918 pandemic.  If so, I plan to be fully armed, with both Vitamin D and the best modern conventional medicine has to offer.

John Cannell, MD
President
Vitamin D Council

This is a periodic newsletter from the Vitamin D Council, a non-profit trying to end the epidemic of vitamin D deficiency.  Please reproduce it and post it on Internet sites.  Remember, we are a non-profit and rely on donations to publish our newsletter and maintain our website.  Send your tax-deductible contributions to:

The Vitamin D Council
585 Leff Street
San Luis Obispo, CA 93401

Image from Nature Reviews Cancer

Avoiding the swine flu

bidengaff

Since I’ve been asked about my take on the swine flu situation a few times in the comments section and numerous times by other people I know, I figured I would post on the subject.  Re the above cartoon: I agree with the President.

I don’t think the situation is nearly as bad as many people – including our esteemed Vice President – seem to think it is.  Whenever I hear reports of panic like those we’ve been bombarded with over the past week, I always think of what H.L. Mencken had to say in such circumstances:

The whole aim of practical politics is to keep the populace alarmed (and hence clamorous to be led to safety) by menacing it with an endless series of hobgoblins, all of them imaginary.

In this case, I don’t think it is the government that is spreading the panic – Biden’s gaffs notwithstanding – instead I believe it is the press.  The same Mencken quote could easily apply to the media.

You didn’t hear about Biden’s gaff?  Well, the spinmeisters got to it pretty quickly.

luckovich_run_for_your_lives

If, instead of running for their lives, people are running to the internet, glued to CNN, and the other 24/7 news channels and reading every newspaper and news magazine that comes along, the press is extremely happy.  It’s what they live for.  When they get a hot story like this one, they are loath to let it go until they’ve milked it for maximum exposure.  And they are milking this one for all it’s worth.  But remember, the media did this same thing a few years ago and inspired the same kind of panic over SARS, which ended up not amounting to much in terms of a real pandemic.

By now everyone knows that the swine flu in question is the H1N1 influenza A virus that was first thought to be similar genetically to influenza viruses that are found in pigs in North America.  More research has demonstrated that some of the genes involved are those that are found in pigs in Europe and Asia as well as birds and humans.

Based on the recent cases, this influenza doesn’t appear to be all that virulent.  In fact, it looks to be much less virulent than the standard old garden-variety flu that is common in the winter.

This influenza virus, like all influenza viruses, can mutate via a process called antigenic drift, which can make it either more or less virulent.  When we get the flu, we develop antibodies to the particular strain of influenza virus that infected us.  As this virus mutates a little, our antibodies can continue to beat it back because it is similar enough to the strain we got that our immune system recognizes it.  After a number of years of antigenic drift, the virus will have changed enough that our immune system no longer recognizes it, and we get infected again.  Measles, mumps and chicken pox are common viruses that don’t go through antigenic drift, so once we have them, we pretty much have immunity against then forever, but not with the flu.  Which is why once you get it, you don’t get it again for a number of years, then you come down with it once again.
Based on my own experience both being infected with the flu and taking care of patients infected with it has led me to believe that the influenza virus is becoming less virulent in general over time.  Why?  Natural selection.

Remember, natural selection works by spontaneous mutations that confer a survival advantage to the organism that carries them.  Such an organism has a better chance of surviving and passing the mutation along to its offspring.  With this in mind, consider the influenza virus.  It lives in humans, birds, pigs, etc.  It typically spreads via droplets disseminated by sneezing and coughing or close physical contact.  Think about what happens if a virus is extremely virulent.  The person (or animal) infected with it gets extremely ill, stays put, and maybe even dies.  This behavior reduces the chance of the virus’ spreading.  If however, the virus mutates to a much less virulent form, people who are stricken with it continue to work and socialize and don’t die.  The virus lives longer in the host and has a much greater chance of being spread, which is better for the virus.  So a lesser virulence confers a survival advantage to the virus, which is why I think the flu has become less and less problematic over time.

What can we do about this strain?

First, I don’t think it will amount to much because of the season.  I’m a firm believer in the notion that reduced vitamin D levels in the winter predispose us to the flu and other viral infections at that time.  Right now, it is late spring and nice and sunny with longer days.  People are getting out more and building their vitamin D.  For this reason alone, I don’t believe we’re going to see a pandemic.

It takes about 12 weeks to grow the virus in culture and use it to develop a vaccine, which is why the CDC can’t just crank out vaccine on the spur of the moment when a virus such as this one shows its face.  And even if a vaccine could be cranked out, it takes a while after the vaccination to develop the immunity, so it wouldn’t help immediately anyway. Since there will be no vaccine, we need to turn to other techniques to protect ourselves.  How can we do that?  By doing all the things we need to do to bolster our immune systems.

This swine flu is a type A influenza, which is a type that can usually be warded off prophylactically with amantidine (Symmetrel), an inexpensive drug that is readily available.  But from my reading, it looks like this particular strain of influenza A is resistant to that drug.  There are a couple of other drugs that are effective in the treatment of this flu – Tamiflu and Relenza – but I wouldn’t use them as a prophylactic.  Keep them in reserve in the unlikely event that you should actually contract this flu.  MD and I have gotten calls from friends and family all over the place wanting us to call them in prescriptions for these drugs, but we have refused because we don’t want to deplete supplies (which are limited) for those who actually get the flu.

As far as I’m concerned, the single best thing you can do is to make sure your vitamin D levels are where they are supposed to be.  On days that I’m not in the sun, I always take a 5,000 IU vitamin D3 capsule.  If I feel like I’m coming down with something or if I’m going on a long flight, I’ll take a 50,000 IU capsule.

In addition to the vitamin D, the other things you can do are as follows:

Eat plenty of good quality protein and fat.  Your immune system is made of protein and fat, so eat what it needs.

Avoid sugar and refined carbohydrates.  A number of scientific studies have shown that sugars and refined carbohydrates increase inflammation and, consequently, occupy much of the capacity of the immune system.

Get plenty of sleep.  Sleep is a great immune enhancer.  Remember all the times you’ve shorted yourself sleep and ended up catching a cold.  Get your rest.  If you have trouble falling asleep, try some sublingual melatonin.  It’s available at any health food store.  Put 1 or 2 mg under your tongue when it’s lights out.  Don’t use the melatonin unless and until you’ve turned the lights out and are ready to sleep.

Wash your hands frequently and keep them away from your nose and eyes.  This is especially good advice when you are traveling or even just out and about.  Someone with the flu (or other virus) sneezes into his/her hand, touches a door handle, you grab the same door handle, then rub (or pick at) your nose, and Bingo! you’re inoculated.  So I repeat: wash your hands and keep them away from your nose.  Hand sanitizers help.  And, as if I need to tell anyone this, try to avoid having someone sneeze or cough in your face.

I would avoid kissing pigs and strangers.  Wait until this scare recedes into your rear-view mirror before you follow the lead of this youngster.

pig-kiss-blog

Follow the above recommendations, and I think you’ll do all you can to minimize your chances for infection.

If you do get the flu, have your doctor give you a prescription for one of the two drugs mentioned above.

But I doubt you will get infected.  And I suspect this whole thing will blow over in fairly short order.