5-Hydroxytryptophan (5-HTP)

To support enhanced serotonin production*

  • increases serotonin levels for sleep enhancement, decreased sugar cravings, and better stress management*
  • can be taken with meals without competing with other amino acids
  • includes vitamin B6 for optimal activity
  • made without flowing agents that can inhibit bioavailability

5-Hydroxytryptophan (5-HTP) is produced naturally by the body, as an intermediate step in the conversion of the essential amino acid L-tryptophan into serotonin. It is commercially produced by extraction from the seeds of the African plant, Griffonia simplicifolia.

Serotonin levels in the body are associated with the regulation of sleep, mood, aggression, appetite, temperature, sexual behavior, and pain sensation.* 5-HTP easily crosses the blood-brain barrier, where it can effectively increase central nervous system (CNS) production of serotonin.* It has been shown to have a beneficial impact on mood, discomfort associated with fatigue, sleep, and carbohydrate craving.*

Supplementing with 5-HTP to support serotonin production is preferable to supplementing with L-tryptophan because, unlike L-tryptophan, 5-HTP cannot be turned into niacin or diverted to protein production.* Additionally, supplementing directly with 5-HTP bypasses the need to convert L-tryptophan into 5-HTP , which is a critical step that can be inhibited by a number of factors, including stress, insulin resistance, increasing age, and deficiencies of vitamin C, folate, and iron. To further support serotonin production, Thorne Research’s 5-HTP formula contains pyridoxal 5′-phosphate, the active form of vitamin B6 and the necessary cofactor for the conversion of 5-HTP to serotonin.*

5-HTP is well absorbed when taken orally, with about 70 percent ending up in the bloodstream* and its absorption is not affected by the presence of other amino acids; therefore, it may be taken with meals.*

Each bottle contains 90 vegetarian capsules
Suggested dose: 1 to 2 capsules nightly

INTERACTIONS/ CONTRAINDICATIONS: 5-Hydroxytryptophan should be used with caution in any individual currently being treated with an SSRI antidepressant. If you currently take an SSRI antidepressant, you should discuss with your physician before adding this supplement.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

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