..man, proud man,
Dress’d in a little brief authority,
Most ignorant of what he’s most assur’d…

From Measure for Measure by Wm Shakespeare
The web has been alive with commentary the past few weeks since Denise Minger lobbed her first cannonball of a critique across the bow of The China Study, the vessel T. Colin Campbell, Ph.D. rode to fame and bestsellerdom.  Seems like everyone is now jumping into the fray and gunning for poor Dr. Campbell, who early on in the fracas made a few halfhearted attempts to fight back but has now fled the scene.  I’ve been laying low watching it all play out, and so now figured it’s about time I add my two cents worth to the debate. But first a little history.
I met Dr. Campbell about ten years ago (five or so years before the publication of the popular book The China Study) when we both spoke at the same conference.  He was a nice enough man who spoke about the work he and his team had done in China gathering the data published in the massive 894 page monograph Diet, Life-style and Mortality in China (pictured above left).  As Dr. Campbell presented his data ‘demonstrating’ the superiority of a plant-based diet and demonizing protein of animal origin, I didn’t think much about it because the data was all in the form of observational studies, which, as all readers of this blog should know by now, despite often showing correlation don’t prove causation.  My lecture, which followed Dr. Campbell’s, was, as you might imagine, a lecture of a different sort.  Then we both sat on a panel after our talks and fielded questions.  And were both cordial to one another.
A few years ago, I became vaguely aware that Dr. Campbell had written a popular book on his work in China titled, appropriately enough, The China Study.  I assumed it pretty much mirrored his presentation I had watched, so didn’t rush out and grab a copy.  Over the past few years a number of people have asked about The China Study through the comments section of this blog, and I’ve typically answered that the data are all observational and so not really meaningful in terms of causation.
(Note: Throughout this post whenever I refer to the popular book Dr. Campbell wrote, I’ll call it by it’s title The China Study, and when I refer to the large study Dr. Campbell was involved with in China and was the basis for the monograph Diet, Life-style and Mortality in China, I’ll call it the China study.)
About a year ago, I wrote a guest post for Tim Ferriss’s The Four Hour Workweek blog.  It actually wasn’t a guest post as much as it was an excerpt of a chapter from our book The Six-Week Cure for the Middle-aged Middle extolling the virtues of saturated fat.  It was a popular post that has garnered to date 520 plus comments, many of them fairly spirited.  I agreed to answer a number of the comments and did so.  I noticed as I sifted through them that a handful were absolutely fawning of Dr. Campbell and The China Study.  Here is a sampling:

The number one study of diet and disease is the China Study. All other data points are slivers compared to the volume of data and statistical correlations that came from the China Study.

Have you read The China Study? Dr. Campbell points out repeatedly that none of the weight loss studies such as Atkins or South Beach diet follow any type of peer reviewed scientific method.

Tim…and to think I was such a big fan of yours. This is by far the weakest (and least cited) argument I have ever read on diet–especially increasing saturated fats. Half knowledge is a scary thing in the hands of influential people. Maybe it’s another genius marketing ploy (like the myth riddled protein Atkin’s diet)–people love to feel good about their personal yet poor decision making–and diet is very personal. Check out researchers that actually meant to study nutrition–like Dr. T. Colin Campbell’s The China Study comes to mind.

It was pretty apparent that the disease of non-critical thinking was at epidemic proportions.
After reading a number of these, I decided I had better take a look to see what Dr. Campbell had going on that had attracted such devotees.  I pulled up his book on Amazon and read through a few comments, most of which were even more nauseatingly gushing than the above.  I ordered a copy of The China Study.
I knew that both Anthony Colpo and Chris Masterjohn had done their own critiques of the original data, so I figured, what the hell, I’ll take a look at the ‘real’ China study (as opposed to the popular book of that name) and do one too.  And I’ll critique the popular book, which I figured was a rehash of the China project, while I’m at it.
I tracked down a copy of the 894 page book in a bookstore in the UK and forked over $240 to purchase it and have it shipped.  As I was awaiting its arrival I told Gary Taubes what I had done, and he replied that he had done the same thing himself a few years earlier.  And that I could have borrowed his.  And, even worse, that most of the data was available online for free.
When the book arrived, I was amazed at the size of it.  Not only was it the 894 pages as advertised, it was in a large format.  Much larger than a volume of the Enclyclopaedia Britannica.  It wasn’t at all what I thought it would be.

Here are a couple of photographs shamelessly using our own book to show the size of this behemoth
Of the 894 pages, the first 82 are a study overview, description of methodology and author commentary.  It is written in the form of a scientific paper with half the page in English and half in Chinese (which, presumably, is a translation of the English half).  The remainder of the 894 pages are raw data and correlations.  Page after page after page of correlations.  I didn’t bother counting them, but Dr. Campbell says there are 367 variables, each of which is compared with every other variable.  I don’t doubt him.  This study was a massive undertaking, requiring thousands upon thousands of man hours and God only knows how much money.  No one can possibly accuse the team members of not giving it their all.

Here is one page of correlations.  This one between stearic acid and all the other variables studied.
But in the end it is still only an observational study.  And even though – again, according to Dr. Campbell – there are over 8000 statistically significant correlations, correlations are not causation.  Any scientist worth his/her salt will tell you that all you can do with data from observational studies is use them to form hypotheses that can be rigorously tested in randomized, controlled trials.  Then and only then (assuming the study results show it) can you even begin to talk about causation. The whole enterprise, costly and time consuming though it was, was described perfectly by Shakespeare in the words of MacBeth:
…it is a tale
Told by an idiot, full of sound and fury,
Signifying nothing.

Once I saw that the original China study was nothing but a huge number of correlations, I quickly lost interest.  What is the point in going through the brain damage of ferreting around in these to see if Dr. Campbell interpreted them correctly when he tries to make his case that a plant-based diet is optimal.  It doesn’t really matter whether he interprets them correctly or not, they are only correlations.  Repeat after me one last time: Correlation is not causation, correlation is not causation, correlation is not causation…
I wondered why Dr. Campbell and his group didn’t spend a fraction of the time and money they spent on this behemoth of a spreadsheet full of correlations on a real study that could provide hard evidence.  Why not randomize subjects into two groups and provide one a plant-based diet and the other a meat-based diet or something similar.  Lock them down as Ancel Keys did if they had to.  Surely the money spent on the China study could’ve covered that.  Get some real data.  I discovered later that I wasn’t the only one who wondered that.  Even some of Dr. Campbell’s own colleagues abandoned him to this study and told him it would be worthless.  More about this later.
So enough for me.  I stuck my copy of the $240 book of correlations in my library and forgot about it.  Until Denise Minger’s critique hit the net.
Upon reading her blog post, my first reaction was This is great; someone took the time to do what I was going to do. I figured Dr. Campbell had cherry picked his correlations to  make the case he wanted to make, and I had seen Colpo and Masterjohn catch him on it.  Ms. Minger went even further and really caught Dr. Campbell with his pants down, correlation-misinterpretation speaking.  I continued to read with mounting glee Ms Minger’s successive critiques and a few other bloggers who had critiques of their own.  (Believe me, there is no dearth of material here for people to attack without any two attacking the same data twice.)
After this went on for a while, I had my second reaction to the whole affair.
Which was that I had fallen victim to the confirmation bias.  My bias was that Dr. Campbell was wrong, so I was more than happy to uncritically accept evidence confirming his error without lifting a finger to double check said evidence myself.  I knew that if a blogger somewhere had come out with a long post describing an analysis of the China study demonstrating the validity of all of Dr. Campbell’s notions of the superiority of the plant-based diet, I would’ve been all over it looking for analytical errors.  But since Ms. Minger’s work accorded with my own beliefs, my confirmation bias ensured that I accepted it at face value.
Once the fact that I had succumbed to my confirmation bias settled in around me, I became suffused with angst.  I had tweeted and retweeted Ms. Minger’s analysis a number of times, giving the impression that I had at least minimally checked it out and had approved it.  I had emailed it to a number of people, many of whom, I’m sure, had forwarded it on.  I’m sure I played a fairly large role in the rapid dissemination of the anti Campbell/China study info.
(It didn’t really make me feel better to know I wasn’t alone in falling into the confirmation bias quicksand.  Take a look at this post from Richard Nikoley’s Free the Animal blog.  I doubt that all these people checked Ms. Minger’s calculations before posting.)
My angst wasn’t because I had possibly fed the flames of a misinformation wildfire – I wasn’t particularly worried about that because mountains of other data (including first hand data from my own clinical practice) have persuaded me that Dr. Campbell is dead wrong in his ideas about the superiority of a plant-based diet.  No, my angst arose for two other reasons: first, because I was distressed that I so easily fell prey to the confirmation bias, and, second, because I felt I needed to go through all the calculations  myself to make sure Ms. Minger and others whose work I had circulated were truly correct in their analyses.
As I was wallowing in self pity over all this, I didn’t realize that salvation was at hand. And that my savior was none other than Dr. T. Colin Campbell himself.
Yep, his first response to Denise Minger’s critique of his work appeared on the Tynan.net website and rescued me from my pit of self-loathing.  In it, Dr. Campbell wrote:

But she suffers one major flaw that seeps into her entire analysis by focusing on the selection of univariate correlations to make her arguments (univariate correlations in a study like this means, for example, comparing 2 variables–like dietary fat and breast cancer–within a very large database where there will undoubtedly be many factors that could incorrectly negate or enhance a possible correlation). She acknowledges this problem in several places but still turns around and displays data sets of univariate correlations.

In other words, the China study is an observational study comparing one variable to another (univariate correlations) and, as such, meaningless.  And this from the man’s own pen.
Since these observational studies are meaningless in terms of causality, it doesn’t really matter how one slices and dices the data because meaningless correlations by any other names are still just as meaningless.  All this falderal over whether or not Dr. Campbell had his interpretations right was tantamount to the medieval theological argument over how many angels could stand on the head of a pin.  And my participation certainly wasn’t required.
I’d known this all before, of course, but somehow had lost my focus on it.
I was ready to wash my hands of the whole affair when I came across another statement Dr. Campbell made in his response to Ms. Minger’s critique.  Writing of her, he said:

One further flaw…is her assumption that it was the China project itself, almost standing alone, that determined my conclusions for the book (it was only one chapter!). She, and others like her, ignore much of the rest of the book.

Only one chapter? As I mentioned above, I always figured The China Study was simply Dr. Campbell’s tale of the China study and the conclusions he had drawn from it.  Now he says that only one chapter is about the China study, leaving me to conclude that the rest must be about something else.  I found the book, which I hadn’t yet taken from the pack it came in from Amazon, opened it and started reading.
In 1976 author Mary McCarthy famously said live on the Dick Cavett show of her rival Lillian Hellman:

Every word she writes is a lie, including ‘and’ and ‘the’.**

I feel much the same way about The China Study.  Except it’s not really a lie, it’s an obfuscation.
In fact, in my studied opinion, The China Study is a masterpiece of obfuscation.
It is obfuscatory in so many ways it could truly qualify as a work of obfuscatory genius. It would be difficult for a mere mortal to pen so much confusion, ambiguity, distortion and misunderstanding in what is basically a book-length argument for a personal opinion masquerading as hard science.
Let me take just one tiny section of the book, one that is in no way atypical, and show you what I mean.
In Chapter 3 titled Turning Off Cancer, Dr. Campbell is starting to hit his stride in his anti animal protein jihad.  He has described the three stages of cancer – initiation, promotion and progression – and is setting the stage for his description of his laboratory work implicating animal protein in all three stages.
Here is his setup paragraph starting on page 50:

At the start of our research, the stages of cancer formation were known only in vague outline.  But we knew enough about these stages of cancer to be able to structure our research more intelligently.  We had no shortage of questions. Could we confirm the findings from India that a low-protein diet represses tumor formation?  More importantly, why does protein affect the cancer process?  What are the mechanisms; that is, how does protein work?  With plenty of questions to be answered, we went about our experimental studies meticulously and in depth in order to obtain results that would withstand the harshest of scrutiny.

The “findings from India that a low-protein diet represses tumor formation” were the results of a rodent study published in the Archives of Pathology in 1968 that Dr. Campbell wrote about 14 pages earlier in the book.  He mysteriously refers to the Archives of Pathology as an obscure journal when it is anything but.  It was published then by the American Medical Association and still is today under the new name Archives of Pathology & Laboratory Medicine.  But the notion of the paper initiating his quest being discovered by Dr. Campbell in an “obscure medical journal” fosters the impression of him as a leave-no-stone-unturned kind of guy.  Even the little throw away but incorrect phrase “obscure medical journal” is part of the greater picture of obfuscation that maintains throughout the book.
The study from India showed that rats given aflatoxin along with a high-protein diet got liver cancer while rats given the same amount of aflatoxin while consuming a low-protein diet didn’t.  Aflatoxin is a substance released from a fungus often found in peanuts, corn, other grains and even hay. It is converted in the liver to a much more toxic compound and is often used in laboratory experiments with animals to induce cancer and other problems.
Moving on, here is what Dr. Campbell has to say about protein and cancer initiation:

[I] How does protein intake affect cancer initiation?  Our first test was to see whether protein intake affected the enzyme principally responsible for aflatoxin metabolism, the mixed function oxidase (MFO).  This enzyme is very complex because it also metabolizes pharmaceuticals and other chemicals, friend or foe to the body.  Paradoxically this enzyme both detoxifies and activates aflatoxin.  It is an extraordinary transformation substance.
[II] At the time we started our research, we hypothesized that the protein we consume alters tumor growth by changing how aflatoxin is detoxified by enzymes present in the liver.
[III] We initially determined whether the amount of protein that we eat could change this enzyme activity.  After a series of experiments, the answer was clear (Chart 3.2).  Enzyme activity could be easily modified simply be changing the level of protein intake.
[IV] Decreasing protein intake like that done in the original research in India (20% to 5%) not only greatly decreased enzyme activity, but did so very quickly.  What does this mean?  Decreasing enzyme activity via low-protein diets implied that less aflatoxin was being transformed into the dangerous aflatoxin metabolite that had the potential to bind and to mutate DNA.

These four little paragraphs and accompanying chart take up less than a page in space, and are tiny glittering gems of obfuscation.  Let’s deconstruct.
First, take a look at how subtly these four paragraphs are written, especially II.  Note how he writes “the protein we consume”?  I’m sure many people took these paragraphs to mean that the studies were done on humans.  That’s almost the implication.  Reread them to see if they indicate anywhere that the author is talking about rat studies.
As Dr. Campbell progresses through this chapter, he does ultimately tell the reader he is talking about rat studies and not human studies, but he doesn’t mention the word rat for another two pages after the above paragraphs. By this time it’s probably implanted in the minds of many readers that he’s talking about human studies.
He describes experiments showing that rats getting diets high in casein (a milk/animal protein) develop more cancer at the same dose of aflatoxin than do rats getting a lower-casein diet.  The implication: animal protein causes cancer.
Dr. Campbell then gave his rats diets of varying amounts of plant protein (wheat gluten) and found that they did not get cancer after exposure to aflatoxin irrespective of protein dose.  Same thing happened with soy.  Implication: plant protein protects against cancer.
If you’re worried about cancer – and who isn’t – you’re now starting to look at animal protein a little differently.  Which is what Dr. Campbell wants.  But he hasn’t told you the complete story.
As I’ve written often in these pages, rodents aren’t just furry little humans.  They are a distinct species separate and apart from humans.  The rodents usually used in lab experiments are Sprague-Dawley rats, and inbred strain that has a tendency to develop cancer easily. (See Abelson, PH. (1992) Diet and Cancer in Humans and Rodents, Science 255(5041); Jan 10: 141)  In fact, these rats can develop cancer just from a change in diet.  I ran quick checks on a bunch of the studies referenced in The China Study, and all checked used Sprague-Dawley rats.
And think about this.  If you were to visit a farm and search for rodents, where do you think you would be most likely to find them?  In the grain or in the milking area?  Like Dr. Campbell, I grew up in a rural area and spent a lot of time on a farm.  Rats and mice are in the hay and in the grain.  You have a helluva time keeping them out of the animal feed, which they eat, too.  Grain and hay are common places for growth of the fungus that produces aflatoxin.  Since rodents spend most of their days in this stuff (grains), and since they eat it as well, I would bet that most have adapted over the generations to  the combination of plant protein and aflatoxin.  If this did them in regularly, there wouldn’t be the rodent problem on farms that there is.  So, in my opinion, making a huge issue of the fact that rats didn’t get cancer after dosing with aflatoxin irrespective of how much plant protein they ate is pretty disingenuous.
Most disingenuous of all in the above four paragraphs and chart is the lack of full disclosure in these paragraphs of the very study Chart 3.2 is made from. Let me explain.
Certain enzymes in the liver convert aflatoxin into a more toxic substance that Dr. Campbell claims can initiate the formation of cancer.  He demonstrates in rat studies that giving the rats a lower protein diet decreases the activity of this enzyme, meaning that the lower the protein intake, the less conversion of the aflatoxin into the really nasty stuff.  Chart 3.2 above and on page 52 of his book shows this graphically.
When I pulled the study from which this chart was adapted (Mgbodile MUK and Campbell TC. (1972) Effect of protein deprivation of male weanling rats on the kinetics of hepatic microsomal enzyme activity, J Nutr, 102: 53-60.) and read it, I found a little disclaimer Dr. Campbell didn’t bother to mention in The China Study.  You can read the last paragraph of the study (highlighted in yellow) below:

Nice, eh?  He hits the nail on the head.  Protein utilization may be influenced by what is eaten along with the protein.  Sucrose (table sugar) was eaten along with the protein used in this experiment.  In other experiments corn starch was used instead of sugar and the effect of the protein on the enzyme was diminished, meaning that the protein along with starch did not have nearly the same effect as protein with the sugar.  Who knows whether or not it’s even the protein that has the effect and not the sugar?  It can’t be shown from this study. That caveat certainly didn’t make in into The China Study.
See what I mean about a masterpiece of obfuscation?
I could go on and on, but I’ll quit after I give you just a couple more examples.
On page 107 of The China Study Dr. Campbell writes:

At the end of the day, the strength and consistency of the majority of the evidence is enough to draw valid conclusions.  Namely, whole plant-based foods are beneficial, and animal-based foods are not.

Then one inch below (literally) he writes the following:

The China Study was an important milestone in my thinking.  Standing alone, it does not prove that diet causes disease. [Italics in the original]

So, the China study produces valid conclusions as to causality, i.e., “whole plant-based foods are beneficial, and animal-based foods are not.”  Yet the China study “does not prove that diet causes disease.”  Say what?
Don’t believe me, take a look at a scan of my copy:

On page 73 Dr. Campbell dons the mantle of prestige conferred by one of America’s most august newspapers.  Writes he referring to the China study:

We had a study that was unmatched in terms of it’s comprehensiveness, quality and uniqueness.  We had what the New York Times termed “the Grand Prix of epidemiology.”

A quick search of that phrase in the online version of the NY Times reveals that it came from an opinion piece by none other than Jane Brody, a kindred spirit to Dr. Campbell.  Brody, a lipophobe of the deepest hue, has written a number of low-fat cookbooks and is a believer in the plant-based diet. So she hardly qualifies as an unbiased commenter.
And speaking of the so-called plant-based diet, when Dr. Campbell responded to Ms. Minger’s critique, he took her to task for mentioning the words ‘vegan’ and ‘vegetarian’ as it applied to his work.

One final note: she repeatedly uses the ‘V’ words (vegan, vegetarian) in a way that disingenuously suggests that this was my main motive. I am not aware that I used either of these words in the book, not once. I wanted to focus on the science, not on these ideologies.

Just for grins, I turned to the index of The China Study to see if ‘vegan’ or ‘vegetarian’ were indexed.  Here’s what I found on page 417:

vegetarianism or veganism. See plant-based diet

When I flipped over  to ‘plant-based diet’ on page 414, I found a long grocery list of references.
Even in his online response to his opponents, Dr. Campbell apparently can’t resist obfuscating.
Okay, just one more, then I’ve got to draw this to a close.  Let’s go back to the bottom of page 52, the page the paragraphs above and Chart 3.2 appear on.  Dr. Campbell shows in Chart 3.2 how protein is involved in stimulating the liver to convert aflatoxin to the toxic product that he implies is involved in cancer initiation.  He then reports how he wanted to see if animal-based protein was involved in the other phases of the cancer progression cascade.  So he and his grad students started to look.  He writes:

As time passed, we were to learn something quite remarkable. Almost every time we searched for a way, or mechanism, by which protein works to produce its effects [on cancer formation and progression], we found one!

That, my friends, is almost the dictionary definition of the confirmation bias summed up in one sentence.
This tiny bit of the book that I’ve chosen to lay bare is truly the tip of the iceberg.  I could go on and on and on, but I’m sure you get the picture.
Before I finish, I want to get back to something I mentioned earlier about how one of Dr. Campbell’s own colleagues bailed out from the China study because he recognized it for what it was: a giant observational study that was meaningless.  Here is how Dr. Campbell describes it on page 105-106:

When we first started this project we encountered significant resistance from some people.  One of my colleagues at Cornell, who had been involved in the early planning of the China Study, got quite heated in one of our meetings.  I had put forth the idea of investigating how lots of dietary factors, some known but many unknown, work together to cause disease.  Thus we had to measure lots of factors, regardless of whether or not they were justified by prior research.  If that was what we intended to do, he said he wanted nothing to do with such a “shotgun” approach. [i.e., a big, meaningless observational study]
This colleague was expressing a view that was more in line with mainstream scientific thought than with my idea [i.e., a randomized, controlled trial that might demonstrate causality would be a better use of the funds.] He and like-minded colleagues think that science is best done when investigating single – mostly known – factors in isolation. [He and like-minded colleagues are correct.] An array of largely unspecified factors doesn’t show anything, they say. [They are right.] It’s okay to measure the specific effect of, say, selenium on breast cancer, but it’s not okay to measure multiple nutritional conditions in the same study, in the hope of identifying important dietary patterns.
I prefer the broader picture, for we are investigating the incredible complexities and subtleties of nature itself…
So I say we need more, not less, of the “shotgun approach.” We need more thought about overall dietary patterns and whole foods.  Does this mean that I think the shotgun approach is the only way to do research?  Of course not.  Do I think that the China Study findings constitute absolute scientific proof?  Of course not.  Does it provide enough information to inform some practical decision-making? [No.] Absolutely.

Dr. Campbell uses an impassioned written speech to persuade the scientifically untrained that the China study carries vastly more scientific value than it actually does. Once again, it’s a large observational study, but an observational study nonetheless.  And as such, it is useful only in developing hypotheses to be tested with randomized, controlled trials.  The entire 894 page study proves not a shred of causality.
What saddens me about all this is that hundreds of thousands (probably millions) of people who can’t (or won’t) read critically have fallen for the premise of The China Study without even thinking about it.  Believing that the entire book is based on the greatest and most important nutritional study ever completed.  What happened to the ability to read critically?  Has it vanished from the populace?  Based on the comments on The China Study on Amazon it would seem so.
In my opinion, there really isn’t much of substance in the entire 400 plus page book.  But I encourage you to buy it and read it to test your own critical reading skills.  If you don’t want to test your critical reading skills, you’ll at least enjoy coming across some real howlers such as this one believed only by the vegetarian/vegan zealots out there (oh, sorry, plant-based diet followers):

As you will see in this book, there is a mountain of scientific evidence to show that the healthiest diet you can possibly consume is a high-carbohydrate diet. [italics in the original]

I wonder if Gary Taubes, who wrote a vastly more scientific book, would agree?
Lest you think I’m being too hard on poor Dr. Campbell, let me tell you a few things.  First, as I mentioned earlier, the few sections of The China Study I dissected are just a tiny fraction of the whole.  I could go on and on. Second, Dr. Campbell mentions Protein Power by name on page 19 and labels it a modern protein fad diet that “continue[s] to inflict a great variety of dangerous health disorders.”  Third, he is absolutely and unnecessarily brutal in his treatment of Dr. Robert Atkins.  He has an entire section on Dr. Atkins starting on page 95 that runs for almost three pages.  After quoting from one of Dr. Atkins’ books, he writes the following about the deceased diet doctor:

There are snake oil salesman, who have no professional research, professional training or professional publications in the field of nutrition, and there are scientists, who have formal training, have conducted research and have reported on their findings in professional forums. Perhaps it is a testament to the poser of modern marketing savvy that an obese man with heart disease and high blood pressure [here he inserts a citation for an article discussing Dr. Atkins’ death] became one of the richest snake oil salesmen ever to live, selling a diet that promises to help you lose weight, to keep your heart healthy and to normalize your blood pressure.

A way below-the-belt commentary when you consider that Dr.Atkins was a trained cardiologist who took care of thousands of real, live patients throughout his career – he wasn’t, like Dr. Campbell, a bench scientist doing rat studies in a lab.  Bob Atkins and I have had our differences, but were he still alive, I would vastly prefer to put my own care in his hands than I would those of Dr. Campbell, who has never treated a patient in his life.
You may ask if I took anything of value from my reading of this book?  I did.  On page 107 Dr. Campbell writes the following:

The results of this study…convinced me to turn my dietary lifestyle around. I stopped eating meat fifteen years ago, and I stopped eating almost all animal-based foods, including dairy, within the past six to eight years, except on very rare occasions,  MY cholesterol has dropped, even as I’ve aged; I am more physically fit now than when I was twenty-five; and I am forty-five pounds lighter now than  was when I was thirty years old.  I am now at an ideal weight for my height.

I have no reason to doubt Dr. Campbell’s own medical and dietary history (except maybe for the part about being more physically fit than he was at age 25 – that’s a tough act for someone who is 73), so I’ll assume it’s all true.  As I recall, he had a trim physique when I met him 10 years ago, which, assuming nothing has changed, is probably the same.  And I’m going to take Dr. Campbell at his word about what he eats.
Granted, I’m younger than Dr. Campbell, but I follow almost the opposite diet as he does yet I, too, have low cholesterol, very low blood pressure and am ideal weight for my height.  What this all tells me is how wonderfully adaptive the human species is where diet is concerned.  It’s no wonder we took over the earth.
** Lillian Hellmann was predictably furious over McCarthy’s comment and adopted the typical American response: she sued.  In one of those turns in which the law of unintended consequences jumps up and bites one, many of her untruths came to light in the courtroom as McCarthy was forced to defend her statement.  Hellmann disengaged by dying during the proceedings.


  1. I think between you and Denise and Dr Colon’s own self-incriminating defense and retreat we can declare this house of cards called ‘The China Study’ officially collapsed.

  2. I am not surprised this one caught your interest. It caught mine.
    I watched the Vegans on 30bad (Thirty Bananas a Day) at the beginning of this trying to re-group and wondering how to to handle the now recidivist Denise Minger and how they might create cover from the “new epidemiology” coming from Denise’ analysis. I was amused as it was an argument about correlations.
    Later I read Campbell’s defense against the “literary upstart” and noted that he claimed his peer-reviewed rat studies were the basis for a conclusion that animal eating was unhealthy based on a principle of “biological plausibility”. This seemed to me a “big claim” so I wandered over to his website and a rat diet. Hmmm, OK.
    In addition, I found a reference to his gluten study, which I tracked down. Here is the abstract.
    Effect of dietary protein quality on development of aflatoxin B1-induced hepatic preneoplastic lesions.
    Schulsinger DA, Root MM, Campbell TC.
    Division of Nutritional Sciences, Cornell University, Ithaca, NY 14853.
    The effect of the quality of dietary protein on the post-initiation development of aflatoxin B1-initiated putatively preneoplastic foci in Fischer 344 rat liver was compared with the effect of the quantity of dietary protein. Feeding wheat gluten, a low-quality protein, during the postinitiation period (between the end of aflatoxin B1 dosing and the death of the rats) inhibited the development of gamma-glutamyltransferase-positive foci when compared with that in animals fed high-quality protein (casein) diets during the same period. Lysine supplementation of wheat gluten during the postinitiation period enhanced the gamma-glutamyltransferase-positive response to a level comparable with that of the high-quality protein. These results suggest that one can inhibit the development of foci either by decreasing the quantity of protein intake and holding the quality of the protein constant or by decreasing the quality and holding the quantity constant.
    OK, if you supplement gluten with lysine then it acts in a similar fashion to casein.
    I was now expecting to find reference to studies focused on lysine, but did not find any. HMMMM!
    So now I had the basis in Campbells own peer reviewed studies for his claim of “biological plausibility”.
    Complete proteins, being animal are cancer feeding, incomplete proteins (like soy and gluten) of vegetable origin do not feed cancers.
    Further research showed me that Chris Masterjohn had pointed this out in his review of the book when it first came out.
    Frankly, I am astonished that a nutritional scientist is promoting the ingestion of incomplete protein on the grounds that “complete proteins” are carcinogens.
    It is bizarre.

  3. I also sensed the glee of many in reading Denise Minger’s analysis, and felt it too. You are correct that we need to be on guard for confirmation bias.
    But. Denise was using China study data not to prove that an animal-based diet is superior, but to show that the correlations relied on by Dr. Campbell were so weak and confabulated as to not support even a hypothesis that plant-based diet is superior. She did that well.
    This is similar to the famous decimation of Keys, in which his observation that saturated fat consumption in seven countries correlates to heart disease was proven not to be even an observation when 22 countries (the data for which was available to him and likely known by him) were examined and any such correlation disappeared.
    Of course we need to read Ms. Minger critically, but the risk that she is bamboozling us or is just confused herself is less given what she was trying to show: Lack of correlation does not even lead to a hypothesis regarding causation.
    Moreover, in a debate we can expect the proponents of the opposing view to point out flaws in logic or premises, but the responses I have seen have been almost entirely sound and fury.
    An editorial comment: Where you quote Dr. Cambell and indicate that the italicized words were in the original (a couple of places), the italics do not currently show up.

  4. bravo!
    thanks for supporting my own confirmation bias! I’m no scientist, so I live quite comfortably with my bias. Knowing that evolution supports my bias and directly contradicts TCC’s hypothesis (that plants are good, meat is bad) helps!

    1. Phenomenal analysis? HOW SO? The guy proves nothing to the contrary?
      Why don’t you, Dr. Eades, prove to us that a high-protein diet does NOT cause cancer????
      Now that would be a phenomenal analysis.

        1. Weston Price was a first class quack, I am sorry to say. I am always amazed of the skepticism people have to adopting a plant based diet.
          True, man has consumed animal products all over the world for a very long time, but there are pockets of populations where people consume far less of it then people do in the western world and people in those places do not suffer from the same debilitating diseases.
          After 30 + years of research, from multiple research institutions of the highest caliber – there is a joint conclusion that the over consumption of animal products is indeed killing us.
          Why not go cold turkey and eliminate them all together ?
          My wife and I live in the infamous Berkeley “Gourmet Ghetto” and we have taken this route. It was not difficult by any means, We eat all that we want, my weight is stable, and my blood pressure has dropped dramatically. I feel better than I have felt in 30 years.
          I might add that we are never going back to our old dietary ways unless
          social situations make it difficult

          1. It is not animal protein that is killing us. There is ample proof that a high carbohydrate diet is the problem. If you are relying on the low fat diet research, then you need to take a look at “The Big Fat Surprise” by Nina Teicholz. She spent 10 years examining all the published diet research and concludes that almost all of it is epidemiological and some downright fraudulent. Current one-factor comparative studies demonstrate the health of a meat based diet.

      1. Perhaps KellyBelly will enlighten us as to how he would prove a negative. Anyone who took a grade school science class learned you can’t.

      2. Old post but I have to say it (someone already might have). You cannot absolutely prove the non-existence of anything so the burden of proof is on the one making the positive assertion.

      3. Just wanted to, belatedly, give you some support. This is clearly the lions den. The response to Minger was perfect. He said all that needed to be said in the responses he did make.

  5. When I don’t see a blog post from you in a while and I see, “The Blog of Michael R. Eades, M.D.” subject line in my email inbox, I immediately rush over to see what you’ve been up to and are reporting on.
    As usual, I see you’ve been amusing yourself with the data out there in a very productive fashion. Thank you! Great post!
    I have a critical reading fun test. Open “The China Study” to any random page. Find as many logical/scientific errors as you can. Forward the page number to a friend and see how many they can find. Fun stuff! Compare what the errors are and which you missed.
    Most importantly, make sure none of your error finds are fueled by confirmation bias, but are actually data driven.
    This is the key. Low carbohydrate diets need to be driven by the data, not our opinions about the data. If low carb vs plant based becomes a religious war, all hope is lost. We must admit when we are wrong and change our positions as better data become available. The search for ideal human diets must stay a search for truth, not false self deluded certitude.

    1. What a great idea! A critical reading fun test. A win-win for sure. Campbell sells more books, but not to promote his flawed views on diet. Instead he sells books to be used as critical reading primers.

      1. Dr. Eades,
        Everyone must have their place within the division of labor, regardless of their original intentions. 😉
        As always, great work. Be well.

  6. My son has a good friend who’s dad is a long time vegetarian. Two weeks ago he had his first heart attack. He was lucky his wife was right next to him as he fell unconscious. He’s at home now with Lipitor and Nitro. His lipids were sky high. I guess that’s what lots of veggies and “hearthealthywholegrains” will do for you.
    And he was a “good” vegetarian, eschewing processed foods in favor of a lot of vegetables.
    A wake up call for him (and his daughter, who also is a vegetarian). Probably not. When you eat for ideology, it’s hard to change. The daughter (20) did ask me for some info on what they should do, and brought me his labs to look at, but mostly she was interested in how to supplement so he/they could still be a vegetarian.
    Frustrating. It’s like they’re saying “I want to shoot myself, but how can I minimize the damage”.

    1. All I can say is….hahahahahhahahahahahahaha!!!!!!!!!!!!
      Yours is the best comment so far! You win.
      I live in Salt Lake City, Utah. There is a women that lives here. She has a website called greensmoothiegirl.com. She loves “The China Study”, she is also like your friend. I heard about “The China Study” from her. I have my own beliefs on diet based on my own PERSONAL experiences raising farm animals and a wide variety of pets.
      I am upset with myself for not investigating this book earlier. What a horrible waste of paper the “China Study” is. Thank you
      Michael R. Eades, M.D you are an eloquente writer. You definitely raise the bar!

    2. “Two weeks ago he had his first heart attack. He was lucky his wife was right next to him as he fell unconscious. He’s at home now with Lipitor and Nitro. His lipids were sky high. I guess that’s what lots of veggies and “hearthealthywholegrains” will do for you.”
      The plural of anecdote is not “fact.” It seems you haven’t read this blog entry at all, or if you have, you don’t really understand it.
      Also, who is seriously taking the advice of this “Dr. Eades” who’s primary interest seems to be defending his “self-help” books that are peddled on T.V. and cheesy websites? Thank goodness the author of “Protein Power: A low-carb solution,” who clearly has no conflict of interest, is here to debunk things for you!

      1. I had never heard of Dr. Eades until I googled “The China Study”. I am not a scientist, but I had noted some of the same inconsistencies he mentions in Campbell’s work. I know enough about scientific research to question the bases of Campbell’s concusions. I didn’t see any advice in this post, but if you are asking who is eating meat and animal fats as part of a healthy diet. I am as are some indigenous peoples who have far better health than those who eat a plant only diet.

    3. Campbell promotes a vegan, not vegetarian diet. I am not a supporter or detractor, but there is a huge difference in the consumption of animal products between the two.

  7. So I understand with this post you gave the starting shot for everybody to stop the hair-splitting, put this China Study back in the bookcase and concentrate on studies that do really matter? Thanks Dr. Eades, I’m sure they will listen to you.

  8. “What happened to the ability to read critically? Has it vanished from the populace?”
    Did the populace ever have the ability to read critically?
    If you want real insight into Dr. Campbell, take a look at his last word on the topic here:
    Note his reaction to direct questions, e.g. “what is the metabolic pathway by which animal protein increases cholesterol?”. Apparently asking direct scientific questions is “uncivil” in his world. Not sure what constitutes a “civil” scientific discussion with Dr. Campbell, if you’re not allowed to question his conclusions. Also note that he did not publish several comments/questions, including a more pointed from me one about how casein could specifically have any effect on cancer development.
    People who have information supporting their hypotheses are generally over-eager to share. People like to be “right”, and love to show detractors “wrong”. No sane person hides key information that shows they are more likely to be right. What possible conclusions can we draw from Dr. Campbell’s unwillingness to address answer questions and share information?

    1. I’m not sure the majority of the population ever really did have the ability to read critically. Most seem to prefer to be given clear cut choices by the so called experts. Do this. Eat that, don’t do this. Our world is full of ‘thou shalt’ and ‘thou shalt not’.
      Two of my co-workers have blatantly stated that doing their own research into diet is too much work. Too much trouble. They just want someone to tell them what to do, and are infinately confused because all of the ‘experts’ disagree.

  9. “What this all tells me is how wonderfully adaptive the human species is where diet is concerned.”
    Therefore disease is probably the result of a lack of adaptiveness. However, understanding correlation as it relates to observation, disease could be also due to a lack of wonderful. ☺

    1. And as we all know, animal protein and fats are wonderful.
      Therefore! Disease is caused by a lack of animal protein and fats.
      Paleo diet proven definitively a la Campbell style logic.
      Didn’t even need to do any research to solve that one!

      1. Ironically you have said something that is true – Staffan Lindeberg’s research is massive and real – and it shows that the diseases of modern civilization are just that – restricted to those that eat the modern grain based diet.
        They are unknown in populations that don’t. Weston Price found the same as he toured parts of the world before they started to eat like we do.
        Populations with a recent introduction to ur diet, Inuit, Polynesians, First Nations in America suffer worse than any of us do – just as their ancestors suffered from the infectious diseases that we brought with us on first contact.
        Jeff there is lots of goo material to read – if all we do is sling arrows – we make no progress.

  10. It appears that Dr. Campbell is consistent in the way he counters those who challenge his ideology. His dismissal of Denise Minger as un-academic and non-institutional [oh, and a girl!], and therefore below him, is quite the same as his argument against Dr. Atkins. When your data isn’t good enough to stand on it’s own, there’s always the ad hominem. And, AS IF the institutional science has improved our health in the last 40 years!!

    1. When your data is not good enough, you don’t dare to publish raw correlations. You must be darn sure about your results.
      “I should point out that when we were deciding to publish these data in the original monograph, we decided to do something highly unusual in science—to publish the uninterpreted raw correlations, hoping that future researchers would know how to use or not use them. We felt that this highly unusual decision was necessary because we were
      wary of those in the West who might have doubted the validity of data collected in China—we had several experiences to suspect this. But also, we believe that research should be as transparent as possible, simply for the sake of transparency, thus minimizing suspicion of hidden agendas. We knew that taking this approach was a risk
      because there could be those who, knowing little or nothing about experimentation of this type, might wish to use the data for their own questionable purposes”
      Dr. Campbell

  11. We can all blame ourselves for having confirmation bias, but when all those N=1 accounts start piling up by the thousands, you get something more important and that is ‘history’.
    I think your little rat comment shows it perfectly:
    “And think about this. If you were to visit a farm and search for rodents, where do you think you would be most likely to find them? In the grain or in the milking area? Like Dr. Campbell, I grew up in a rural area and spent a lot of time on a farm. Rats and mice are in the hay and in the grain. You have a helluva time keeping them out of the animal feed, which they eat, too.”
    You can call it an observation, which it is, but when bunnies get high cholesterol because they’ve been fed meat, how do these people justify that (and vilify meat) when they’ve just been standing outside protesting for the ethical treatment of lab rats?
    Sometimes I think these academician scientists need to get out more. Tag along with Bourdain or take a trip to Spain or France. They can visit the caves and see the paintings of tofu turkeys at Lascaux.

  12. Thank you, thank you, Dr. Mike. I’ve spent a few frustrating afternoons of late w/ friends raving about their “new” carb diets and their low-fat approach to life (one a diabetic, one w/ high cholesterol) and another selling his version of health by praising “the china diet” study (so he now eats virtually no meat) and tried (gently) to suggest they might be barking up several wrong trees. All to no avail. My husband’s comment that “that cholesterol stuff is all proven nonsense” got their attention, though (because HE said it? dunno). At any rate – finally something to send along to them. Maybe the cool light of reason will dawn here in the hinterlands.
    So happy to see you back at your “post” and thanks for your detailed analysis of this particular brand of obfuscated prose.

  13. Woah, thanks for the traffic boom!
    “He hits the nail on the head. Protein utilization may be influenced by what is eaten along with the protein. Sucrose (table sugar) was eaten along with the protein used in this experiment..”
    Great observation! In another of his papers (“Modification of spontaneous mammary tumors in mice fed different sources of protein, fat and carbohydrate”), he notes:
    “The only groups with 100% tumor incidence by 120 weeks of age were those fed diets containing sucrose (table sugar) or a high fat level [corn oil or butter].”
    Not only that, but the type of fat played a role as well — check out his paper “Effect of dietary intake of fish oil and fish protein on the development of L-azaserine-induced preneoplastic lesions in the rat pancreas.” Fish oil was protective, corn oil spurred preneoplasic lesions.

    1. You truly deserve a traffic boom for getting the ball rolling on all this. Thanks for all your effort and thanks for the heads up on the other papers.

    2. I think you are both mistaken when you refer to the study: “Effect of protein deprivation of male weanling rats on the kinetics of hepatic microsomal enzyme activity”. Authors specify that sucrose was used INSTEAD of protein in the mice fed a lower protein diet. That is, the diet of 5% protein was the same as the 20%, with 15% protein removed and substituted with sucrose for the corresponding calories. You missed the word “deficiency” used in the paper, that refers to the low protein diet.
      Thus consuming more sucrose and less protein showed a decrease in enzyme activity. And corn starch was less effective than sucrose.

  14. Thanks for another great post…
    In this sentence, did you mean to write spend?
    “I wondered why Dr. Campbell and his group didn’t spent a fraction of the time “

    1. I did indeed mean to write ‘spend.’ Thanks for the heads up – I’ve made the correction. And taken the time to severely discipline MD for missing a typo in her proof reading. 🙂

  15. Sounds like the actual data sets from the China Study might be mildly interesting when going over nutrigenomics data coming off of multivariate micro-arrays.
    Seems that this sort of data and view of science (no mechanism really, all correlates and anecdotes) is even pre-1960s.
    It is not technically difficult to do the large variable genomics studies anymore – its all (or isnt) in the annotation.
    With respect to annotation, the China Study data may be of interest tho the data may well be considered rather deprecated.
    There are so many confounding factors in all observational studies (known, unknown, non-intuitive) that bias becomes almost the single most important factor.
    Who needs that when we can do rigorous studies on mechanism as well as robust deep observation via nutrigenomics.

  16. Why is it that we, and I mean people in general, worship other people just because they can produce a massive book and they have Ph.D. behind their names? This absolutely drives me crazy! What is it in human nature that some, if not most, of us apparently feel the need to be followers, to give up our God-given ability to choose, to decide for ourselves what is true and logical and what is not true and/or logical, and give that choice to somebody else? Are we just lazy? Is it that we just don’t have the time? It wouldn’t be so bad if we just admitted that we didn’t know, that we were indeed too lazy or too time deficient or, maybe more honestly, not interested enough, and we were “reserving” judgment, but then we have to latch onto someone elses’ beliefs as if we formulated them for ourselves through careful study and investigation of all the studies involved. Why can’t we just say, “I don’t know and I don’t care. I know what works for me and I’ve seen what works for some people close to me and I’ve seen what doesn’t work”. My brother-in-law died this year from eating the USDA diet for years. He had gall stones, developed acute diabetes and NAFLD. He went into the hospital for three months and died as all his organs quit on him. His wife has had Crohns disease and Lupus for years. When I was there for his funeral last March I sat in horror as I watched her eat a bowl of cereal with low-fat milk. Ten years ago I tried to tell them that they were killing themselves but they would not listen. He was 63 and she is around 62. They worship their doctor and government agencies.

        1. We shouldn’t worship anything. We should allow ourselves to understand sciences such as biology and search for the answers.
          Calories don’t make you fat, insulin does. Carbohydrates trigger insulin secretion.

  17. FYI – thought readers of this blog might be interested to know that HBO’s Taxicab Confessions recently aired an episode where an occupant of the cab claimed to have lived for quite a while in Tanzania with the bush people. He described their way of life, including how they hunted and what they ate. He described how they hunted mostly large animals, and was amazed that the feeding would go on for days, usually 3, until the entire animal was consumed. Afterwards they might go for days without eating anything.
    Although the segment was not very long, it was fascinating; definitely a thumbs up.

  18. I have said it before, and I will say it again. The more folk who don’t bother reading critically, the more low-fat/high-carb dieters, just means eventually there will ultimately be less of them due to disease, infertility, et.c.
    To quote Dennis Leary: “More meat for the meat eaters!”

    1. But it hurts when you have to watch them die and you know that if they had just listened to you they would live longer and be healthier. I’ve been “blessed” with dozens of friends and family members that are dying slow deaths like this. It is almost too much to bear.

      1. You’re right, Stephen Brand. It’s very tough to watch. In my case, it was a dear friend with Crohn’s, who was treated with prednisone, which resulted in osteoporosis, which was treated with Boniva, which gave her necrosis of the jaw. The pain from all this was treated with Vioxx, which resulted in strokes. The Vioxx was discontinued, but her idiot doctor put her on an ultra low fat diet to “prevent more strokes.” A final stroke felled her in her early 50s. When all this started, I had just started my own research on all this diet stuff, so I didn’t have the information I needed to make suggestions. I just knew that the medical profession wasn’t helping her.

        1. Recently, my youngest son’s girlfriend became symptomatic. They thought it might be Lupus. They finally settled on fibromyalgia, which, as you probably know, is the diagnosis they use when they’ve eliminated everything else. They put her on Lyrica. This made her depressed so now she takes Zoloft. I wrote her a letter and downloaded and printed some web pages that literally took me several days to complete. I printed out a dozen web site pages on leaky gut, gluten, gluten-containing foods, gluten-free diet, the horrible side effects of Lyrica and Zoloft. I warned her about how difficult it would be for her to try to go back to school and get her masters and what would happen when she wanted to get pregnant. I copied the chapter on Leaky Gut Syndrome from PPL. When she read the letter she complained to my son who got mad at me. The next time they visited, a couple of weeks later, she sat me down, very nicely told me to mind my own business, and informed me that she was pretty smart and had done some reading on fibromyalgia and gave me some jumbled BS about “substance P” and how that might be the cause. How can people be so stubborn not to at least consider that what you are telling them is right? Grrrr. Friends, family and aquaintances who are in ill health because of their diet surround me! It’s frustrating.

          1. I have had fibromyalgia for years now. I rarely eat red meat, and most of my diet is vegetarian. I was able to work on Lyrica, which has no effect on serotonin. Low substance P has been consistently linked to increased pain; fibromyalgia suffers have increased substance P when spinal taps are preformed. I suggest you look on Medline or some other website with journal abstracts. While the disease is still not well understood, many patients actually have low iron and vitamin D levels, indicating they should actually be eating more meat and cheese. In this one instance, I think you need to educate yourself more sir.

    2. In other words, human plant eaters like vegans and vegetarians are essentially selecting themselves for extinction. It is ironic since they think they are doing it for better health and instead gradually making the human species less able to withstand and survive the next big extinction event that nature will inevitably toss our way.

      1. Ah, but how many generations can they continue?
        The current veg*ns had probably meat eating parents and
        so built their bodies on an non veg*n diet, however the next
        generation, belike, will have many more problems.

  19. Thanks for taking the time Dr.Eades to share your thoughts on the recent
    “firestorm” Ms.Miniger’s blog post created. Your august credentials certainly pack a whallop.I read her post last week and followed the link to the Campbell response over at Tynan.net. He just blogged that he is now “eating meat!” Here’s a link , http://tynan.net/ . If he’s serious or not, I don’t know, bound to ‘get ’em going”.
    I was a patient at your Foxcroft clinic in Little Rock back in the late 80’s and when Protein Power was published, bought a copy, and have enjoyed basically a low carb lifestyle since. The one glaring fact in all this, I think are the harsh verbal attacks on Ms.Miniger, reminded me of the 3-masked studs that attacked Lierre Keith with a red pepper pie. Like to see them do that to Ted Nugent, a real meat eater. The slogan should in fact be, “hey, lets not let the science and facts get in the way of a good marketing plan.”

  20. I always enjoy reading your blog, Dr. Mike.
    BTW, if you had the correct “share” button to repost to Facebook, I would post it there for the benefit of some of my friends who are “watching their cholesterol,” and for one of them who has urged me to follow him on a so-called “China Study” diet. He has lost weight, though, and apparently also put a diabetic relative on the same diet.
    I politely told him that I didn’t think I was going to stop eating meat.

  21. Good job, Mike. How much of our public health is jeopardized by nothing more than pervasive petty hatred of Dr. Atkins who isn’t alive. My prediction, though, is that you will think much more highly of Campbell once you dip into the recently released the report of the Dietary Guidelines Advisory Committee. Compared to that report, Campbell is an intellectual giant.

    1. You are correct on all points. And if Campbell is an intellectual giant, what does that make those on the DGA committee?

  22. I just wanted to say thanks, Dr. Eades, for taking the time to do the research and write this post. I hope that one day I am able to think as critically and clearly as you do.

  23. Dr. Eades,
    From what I can tell the China study is a deductive study of sorts which assumes a meat based diet is cancer causing and therefore a veggie based diet is superior. Without that deductive assumption, it is irrelevant.
    Inductive science, as you point out, is far superior in drawing repeatable conclusions. But, i do have the following question.
    Without having read the book, do you feel there is any value to the raw data? Perhaps take out the gross conclusions, can something be redeemed from this effort, or is all a loss?
    My own confirmation biases aside. Gary Taubes book was enough to confirm my personal experience based on my own athletic performances. Your post has merely strengthened my own convictions.
    BTW: I share @Pam Maltzman’s thoughts on you getting a share button for Facebook. I did repost this onto my FB page.
    This may help:

  24. One reason I appreciate your posts is that you have, as well as the intellect to analyze the material, the insight to realize that you might have confirmation bias as well, Not everyone can admit that.

  25. Great article Dr. Eades. Loved it.
    Its important to note that the soul carcinogens in the sited study were aflatoxin and its metabolites. The dietary effects were secondary. There is no mention of cancer rates of high plant diet vs. adequate protein diet– in absence of a known carcinogen.
    Had the diet had a direct effect on tumor growth or angiogenesis, then he might have been on to something.
    That was decidedly not the case: aflatoxin promotes the cancer. It is beyond obfuscation, it is flat out lying, to say that, based on that study, protein promotes cancer.
    You’re the only person I follow on twitter and I get tons of great references. I almost feel guilty using your posts. It’s too easy.
    Thank you for your work,

  26. Wonderful post, Dr. Eades! Thank you. You and MD are among the Heroes, for sure. (You, too, Denise). Like another commenter said, I’m not a scientist so I can live by my confirmation biases. Actually, I live better than ever because of them and, in fact, so do a number of people whom I’ve been able to convince to come over to the light side of the Force.

  27. A great point about confirmation bias–keeping this in mind helps keep us honest.
    Minger’s post inspired me to finally look at the program Body for Life, which I was on for six years. I’m now cringing when I read the book.

  28. I have no problem with the shotgun approact that was the china study correlations. In fact, I think such things are needed in order to get an overall idea of what ‘might’ be going on with multiple variables interacting. THe prob is when people attempt to use this data in ways other than as open minded scientists hypothesizing about the real truth whatever it might be. If the data was used correctly and science was used correctly, then there would be no problem. But no matter what kind of studies you do, if a scientist is so biased as to try to obfuscate the truth, then the truth will likely not be found. In this, Campbell seems to have taken some lessons from Big Pharma!

  29. I think there are even more overt things wrong with his linking casein and cancer in the rat study:
    “Paradoxically this enzyme both detoxifies and activates aflatoxin.”
    So protein is necessary for the essential process of detoxification (which in this case, in cancer-mice, leads to heightened cancer risk). That rather implies that protein is very important, not a risk.
    This is especially so given that he writes:
    “the comparisons…can largely be assumed to represent deficiency per se.”
    So the comparison isn’t “plant protein” versus “animal protein,” it’s really complete protein versus lack of complete protein (man cannot live on gluten alone). Deprivation of complete protein prevents certain necessary processes, like detoxification or growth. This reminds me of the fact that reduced zinc and iron status can lower the risk of certain cancers. This is unsurprising since these nutrients are essential for growth and cancer is essentially a question of growth. The conclusion to draw is not that zinc, iron, protein (any nutrient at all) is a risk and we should conclude unnutritious or incomplete foods instead.

  30. Don’t you mean “man cannot live on gluten at all”?
    As far as I know, aflatoxins are only found in vegetable foods, especially peanuts.
    All proteins are not equal. Casien is to animal proteins what gluten is to vegetable proteins. Research using casien as a representative animal protein proves nothing; it is comparable to using mature opium poppies as a representative green leafy vegetable.
    This is not the only experiment to find that casien increases liver cancer growth; it also has this effect on liver cancer caused by safrole; biotin decreases the tumours (this experiment was cited, unreferenced, in the book Legal Highs under “safrole”. These effects are probably due to the immunosupressive effects of beta-casomorp hin 7 (BCM7), an exorphin similar to those found in gluten digests. A2 milk (from Jersey cows), hard cheese and butter supply very little BCM7 compared to uncultured milk or pure casien. See the book “The Devil in the Milk” by Woodford.

  31. Sorry to be bossy, but you gotta read these!
    ‘The Disappearing Spoon, And Other True Tales of Madness, Love, and The History of the World From The Periodic Table of the Elements.’ by Sam Kean.
    The Other Brain, R. Douglas Fields
    Survival of the Fattest, Stephen C CUnnane

    1. I never mind people being bossy about book recommendations. I’ve read the latter two, but don’t have the first one yet.

  32. David Moss
    ‘ ..reduced zinc and iron status can lower the risk of certain cancers.’
    Yes, and it looks as if this might explain Campbell’s results. Animal proteins seem to make iron and zinc more available than plant proteins do. Here’s some quotes from this paper:
    ‘Several investigators have noted that dietary iron was more bioavailable to humans when animal rather than soy proteins were fed ..’
    ‘Zinc was less bioavailable from the diet that contained soy assay protein than from the diet that contained lactalbumin .. These data confirm the observations of other investigators ..’
    Another interesting paper says that aflatoxin plus iron overload causes liver cancer in Africa:

  33. Something else interesting about casein and liver cancer. It seems that casein doesn’t promote uptake of manganese as well as soy protein does:
    ‘Liver manganese was higher (P less than 0.0001) in soy protein-fed rats .. than in casein-fed rats .. manganese superoxide dismutase activity also was higher in soy protein-fed rats than casein-fed rats ..’
    This is important, because increased expression of manganese superoxide dismutase ‘suppresses cancer phenotypes in a large number of human and murine tumours.’

    1. @Jane That is interesting. Magnesium supplementation also upregulates manganese uptake and SOD and other antioxidant enzymes (perhaps not surprisingly given its multiple co-enzyme activating roles). Magnesium deficiency is perhaps the most characteristic of all the nutrient deficiencies caused by gluten sensitivity.
      My point is that experiments feeding animals on soy protein, casien or lactalbumin tell us nothing about vegetable vs. animal protein, because these proteins have unique effects that are not shared by other vegetable or animal proteins. Also, in foods (as opposed to pure protein isolates) the vegetable proteins tend to come either with more carbohydrates than animal proteins (legumes and grains), or with more PUFA (nuts and seeds) and these factors (as we now know, thanks to you Dr Eades) are far too important to overlook and expect meaningful results.
      One could perhaps compare a diet of fresh (not processed) meat, fish, poultry with one of legumes, nuts, seeds, grains; but even so, what sensible meat eater ignores healthy vegetable foods the way a vegetarian ignores healthy meats?
      In the real world, the choice is between vegan diet, vegetarian diet with dairy products (probably the worst animal food for most of us), or the vegetarian diet with added meat (omnivore diet).
      Vegetarians may avoid much disease because they avoid eating processed meats (often with added gluten) and casien-rich, uncultured dairy products; but a meat-eater who avoids these foods and also avoids gluten may do even better.

  34. Great post. I was so thrilled by Denise’s critique on the China Study but I totally agree with you that we should all not fall victim to the confirmation bias. Critical thinking is important and we should not just accept anything our doctors or experts spew out, especially on health.
    Have you seen this study?
    and how it is reported in the news?
    We have here another study that is epidemiological in nature, which will be used in the future to promote a meat-less and low fat diet. Seems to me like another lack of critical thinking and a confirmation bias by the media.

    1. Yeah, there seems to be some spin going on.
      I think basically the study said that if you eat a 450 kcal of steak every day instead of 450 kcal of non-meat, then in 5 years time you would weigh 4lbs heavier.
      I can’t tell from the abstract whether they attempted to measure bodyfat in any manner, but right off the top of my head I would wonder if maybe the meat eaters retain muscle better.
      I guess meat calories are different than non-meat calories after all…

  35. The China Study is like the Vegan Bible basically. They were all in awe of the immensity and SCIENCE behind it.
    Tynan.net saying I EAT MEAT NOW in his new post is like you coming out with a post saying Post-Exercise Lipitor Supplementation Improves Muscle-Mass.
    Thanks for the break-down.

  36. I just found this paper about casein and iron:
    It says a peptide derived from intestinal breakdown of casein improves iron absorption.
    I also found this paper saying that lysine does the same thing:
    This might explain Campbell’s finding that adding lysine to a plant-protein diet makes it just as ‘bad’ as an animal-protein diet.
    ‘It has been postulated that low molecular weight chelates are essential to iron absorption and that they function by keeping iron in solution (refs). A number of chelating and complexing agents are effective (refs); however, the amino acids are of special biological interest because they constitute a large ligand pool in the intestinal lumen (refs). Prior work from this laboratory has shown that certain amino acids are effective in increasing (iron) uptake from isolated duodenal segments, and under certain circumstances, they can increase iron retention in intact rats (ref).’
    The three amino acids found to increase iron absorption were histidine, cysteine, and lysine.

  37. What a great analysis. I’ll be sure to share. But, why encourage everyone to BUY this book, which will only make Dr.Campbell a millionare and be given prestige in the publishing world. How about we get it from the library? Or borrow a friend’s copy, or better yet, steal one from a whole foods!

  38. In Campbell’s latest reaction to Denise Minger’s critique he confesses to his “confirmation bias” quite openly:
    “I was simply asking the question whether there were biologically plausible data in the China database to support the findings gained in our laboratory,…”
    So he obviously didn’t look for Popper’s one black swan, information that might REFUTE his hypothesis about the biological pathway between animal protein and cancer.
    It is worth pointing out that Wikipedia in its entry on the China study comes up, under the misleading heading “criticisms”, with this bit:
    “Campbell personally responded to Minger’s criticism showing Minger, who has no scientific background, has little understanding of scientific methods and made multiple serious errors in her analysis.[43] An epidemiologist also weighed in on Minger’s analysis, stating Minger was “incredibly naive in her crude analysis of [Campbell’s] raw data.” The epidemiologist further stated Minger’s “analysis was crude at best and completely wrong at worst. No card-carrying epidemiologist would EVER be able to publish her results and draw the conclusions that she does.” [44]

    Campbell does , of course, no such thing. He throws back at Minger the very argument against him and the examples Minger uses to sustain this argument: his misleading use of univariate analyses. The snooty reaction of that “card carrying” epidemiologist seems to be based on the same bad reading.

    1. When Wikipedia looks wrong, think twice and consider your sources. If it still looks wrong — or just worded wrong — click “Edit” and fix it. There’s no need to fuss about the formatting, just the facts.
      Think of it as a civic duty.
      BTW, writing [[fat]] links to the article titled “Fat”. Writing [http://www.mreades.wpengine.com/drmike/cancer/the-china-study-vs-the-china-study] inserts a link to this page. Use preview.

  39. I don’t have a comment about this study but wanted to say it was nice to see you writing again and I’m glad you are home!
    who has finally made it down from 52 to 30 units of insulin a day!!!!!!

  40. I’m curious, Dr. Eades. Is this blog entry simply not attracting the true-believing Cambellite Brethren & Sistren? Or are you not letting their comments go through?

    1. It must not be attracting the true believers. I haven’t deleted a single comment. Maybe the true Cambellite’s (as you call them) have been so beaten down by the deluge of negative posts about their leader that they’ve taken cover.

  41. Hi Dr. Eades:
    I find all of the mudslinging back and forth between high protein and low protein proponents tiring and unhelpful. This last batch with regards to T. Colin Campbell is along the same lines. I’m a biologist by training (I’m a public school Principal by vocation). I wish I knew who to trust with nutritional advice. A lot of people, yourself included, seem able to peruse the literature and cherry-pick studies that support your hypotheses. It might be that T. Colin Campbell does this, too, to some extent, but it’s just so hard to tell with all of the ad hominems going back and forth. I don’t think that Campbell is the only one who engages in, possibly, “obfuscating” from time to time. I guess what my question boils down to is this:
    Who really wants to know the truth and is willing to honestly go where it takes him/her, and at the same time is trained and skilled enough to navigate and evaluate all the research fairly? I think you would claim to be such a person. Who has the courage to change his or her mind, even if it is publicly embarrassing, based on new evidence (or a closer look at the existing evidence)? Would you say that is you, too?
    Who can you trust?
    Sadly, Dr. Eades, I have to say that I don’t think I can trust you. You are another diet physician slinging the mud around and – it appears to me – engaging in disrespectful attacks on others. I understand. I’m sure you get a lot of it yourself and it’s just human to respond in kind, especially in the blogosphere. I can forgive you somewhat for that, and by that token I guess I would extend the same for T. Colin Campbell. I’m not sure I can trust him either. The work of his that I’ve read (I haven’t read the China Study yet) goes back 10 to 20 years, but it was (as I recall) quite scholarly. I could be wrong.
    Why can’t I trust you, though?
    1. Years ago, I picked up your book, Protein Power, in the bookstore, and thumbed through it. Two things popped out at me that were immediate deal-breakers. There was the chapter called the “Evidence from the Pharaohs” (or something similar). My God, what a stinker! You suggested that since the Egyptians ate a lot of bread, and the mummies of Pharaohs revealed that they had lots of health problems, therefore high carb diets caused those health problems. This is probably the worst example of evidence, coming from a doctor, I’ve ever heard. As if Pharaohs ate the same things that the common person at that time did. As if this isolates for other variables. You lost your credibility with me, pretty much completely, with that chapter. I still find it unbelievable that you would put that forth as evidence.
    2) You suggest that vegetarians should read “a little gem of a book” (your description) whose name now escapes me, by a farmer who describes a world “red in tooth and claw”. This would, you suggest, set them straight about having any feelings for animals that would convince them that it’s not okay to raise, kill, and eat them. Animals kill each other, animals are cruel, nature is cruel. Therefore – I’m giving you my interpretation here – don’t worry about any feelings of compassion you might have for sentient creatures that humans raise for food. Suggesting this so completely misses the mark, and is so insulting to the intelligence of compassionate vegetarians, that I felt immediately repulsed. It gives the impression that you think vegetarians are incapable of abstract thought, and are at best well-meaning buffoons who should give their heads a shake and follow the nature-red-in-tooth-and-claw rulebook, as if that sets some kind of gold standard for compassionate behaviour – that we can’t do better than nature’s playbook.
    3) There are other things…you operate a commercial website on which you sell expensive supplements that are clinically unproven (“Immunopro”, “Daily Regimen” etc.). “Enhance your immune system” indeed. That’s the vague and meaningless claim that you can make under the FDA rules – just don’t say that it cures or helps an actual disease or condition (but I think you know that). Do your commercial interests outweigh your ethical obligations as a physician? Can’t say for sure, but this is a large, smelly black mark against you. Your views don’t reflect those of the American Heart Association and a considerable body of peer-reviewed, publicly-funded research. Like most “alternative” medical practitioners, you say that “mainstream” science that disagrees with your assertions (like the AHA) is wrong, while you – a fearless pioneer – make extravagant claims that science doesn’t support. You produce dismal infomercials to sell your books and products and use testimonials as if they were evidence – I’m not even sure that you understand why that is bad science.
    Would you have the courage to change your mind publicly, based on new evidence? Or will you ride your Protein Power horse into the sunset, come hell or high water? Nothing I’ve seen from you inspires me that you would choose the former. I would hope that I’m wrong. But I’m afraid you just don’t earn my trust and I can’t in good conscience recommend your work.
    Not knowing who to trust (the closest I’ve come to it is Stephen Barrett, M.D. at http://www.quackwatch.org/06ResearchProjects/lcd.html) and the doctors at sciencebasedmedicine.org (http://www.sciencebasedmedicine.org/?s=low+carb), I guess I can only rely on primary sources (and all the work inherent in judging the relative worth of each study). Too bad, it’s a lot of work to do this as an individual.
    I am assuming that you will dismiss my criticisms in the usual way (I am sorry, I am really not trying to insult you with that comment – it’s really what I honestly think). You are undoubtedly a good person who is trustworthy in most parts of his life. Thanks for accepting this feedback.

    1. Thanks for the thoughtful comment. I’m not going to address all of your concerns or critiques of my ethics, but I will address a couple.
      First, based on your comment, it’s difficult for me to believe you actually read the chapter on diet and early man. The small section on diet and the ancient Egyptians was just a small part of the entire chapter. I thought it was important because it demonstrated that a population of people who existed before sugar, as we know it, existed and who consumed a high-carb,, whole-grain diet, suffered from all the medical conditions – heart disease, diabetes, obesity and probably high-blood pressure – that people do today. And to show how ridiculousness of the mainstream nutritional advice – the advice to follow what is basically an ancient Egyptian diet – when that advice is given to prevent the very diseases the ancient Egyptians suffered.
      Second, you obviously didn’t read the little gem of a book – The Covenant with the Wild – or you wouldn’t have so completely mischaracterized it. And you have totally mischaracterized what I had to say about it.

    2. @Brett,
      “I wish I knew who to trust with nutritional advice.”
      Maybe you should trust yourself. The only person with your best interests at heart is you.
      “Too bad, it’s a lot of work to do this as an individual.”
      Then I guess you’re doomed to ride the coattails of the “guru of the day”.

      1. Thanks for your comments, Dave.
        “Maybe you should trust yourself. The only person with your best interests at heart is you.” Certainly a great sentiment, and I support it, though not entirely. Try as I might, I can’t be an expert on everything. I’d love to build an airliner from scratch in my backyard – just can’t seem to get the navigation, hydraulic, engine, or life support systems to work. Are you having any luck with this? I’ve also learned that I can be dead wrong about a great many things. It happens far too often, and it’s going to happen again. I am, for better or for worse, human. Trusting myself is entirely valid when I’m (for example) redecorating my basement (please don’t talk to my wife about this). It’s not so clear that it’s a good thing when it comes to topics where I’m out of my league in knowledge, training, or experience. For example, there exists a “controversy” about vaccinations for children and the increase in reported cases of autism. This is a very important decision! The health, perhaps even the life of my children is at stake. Should I trust my “mommy instincts” (like Jenny McCarthy), listen to people like the fearless pioneering physician (or discredited quack) Andrew Wakefield, follow the mainstream advice of my pediatrician, or go become a pediatrician myself? That last one might not be a timely option anymore. The health of my children requires an immediate decision. What do I do?
        I don’t know you, Dave, but I would hazard, as a guess, that I know more about what constitutes effective pedagogy and improving the achievement of at-risk students in public schools than you do. I am a relative expert in this field, and my job involves the practical and theoretical application of educational research. If you were the parent of an at-risk student, I could provide you with practical, proven support strategies for your child that would immediately improve his or her prospects for success. I earned this expertise through training, application, experience, and ongoing study. You can say that you could do just as well (or better) in helping your son or daughter, as a lay person, by “trusting yourself”, rather than listening to advice from people in the field, such as myself. But do you really think that’s the best that you can do for your most important decisions? More generally, is there a place for expert advice in your paradigm?
        Having a reliable source of advice on complex matters, such as nutrition, can be very helpful. Too bad it’s so rare. Don’t worry, Dave. I can think for myself and can make decisions in the absence of good advice from relative experts. But I also understand the value of good advice from relative experts. I hope that you can, too.
        “Then I guess you’re doomed to ride the coattails of the ‘guru of the day'” I always find being doomed to be so depressing… it’s okay – this is not going to happen for me, and, I hope, not for you, either. Thanks again for your comments, Dave.

    3. Bret, I sympathize with you, brother. If one is not confused about what is the “best” diet for human beings then he simply hasn’t been studying what all the “experts” have been saying. Here’s the solution: try one of the diets…duh. Pick up a representative book on each of the major diets. Read the book. Get a lipid panel. Try each diet for 6 months following the book EXACTLY. Get another lipid panel (one that breaks down LDL like NMR or VAP not the one you usually get from your PCP). Also, make sure to keep a log about how you look, feel and perform. Go with the diet that makes you look, feel and perform at your best. If you cannot adhere to the diet for six months, then that has to be taken into consideration when you’re deciding if that is the diet for you. Good luck!

    4. Brett, if you are listening to the dudes at quackwatch and science based med, there is no hope of ever getting you back on the right track. Stephen Barrett isn’t even an M.D. (check out a bio on him if you don’t trust my word). He lost his license. Years ago.
      If you prefer to believe what they say, however, there’s nothing which can be said here that will matter.
      Good luck with their advice. As for me, I’ll stick with http://www.westonaprice.org , Dr. Eades, Chris Masterjohn and Paul Maher, M.D. I’ve never seen such common sense based advice. It’s just great, and the science proves them out, as well (If you believe in science). Most science is bogus but that’s another post. Nevertheless, I think you need to re-read and re-think this subject and then comment again.

    5. I believe you’re looking for Stephan Guyenet’s blog at wholehealthsource.blogspot.com.
      I like this blog, but it’s more preaching to the choir than anything. If you want generally calm, civil discussion of the data and development of new viewpoints, check out his site.
      As far as your expertise in pedagogy, it would be interesting to see what you have to say about keeping at-risk gifted students from becoming bored by standard curriculum, and things like zero-tolerance policies.

    6. This is the most sensible comment I have seen so far. Th rest of “ayes”/”hurrahs” we have seen are the people who are already in the “protien” camp. Personally I am not a vegan or a vegetarian. But given todays problems with animal products ( hormones, mad cow disease, bird flu, fish raised in a unhealthy environment) I rather avoid animal products as much as I can; or get it from a ver trusted source. I do think that humans are not meant or need to consume such a high protien diet; especially for those of us who are relatively sedantary. (Early humans had a far from sedantary life style) Also given the number of humans on this planet it is not feasible to feed a high protien diet to all. The China study has shown that is not only possible to lead a life based on plant diet but it could also be beneficial to lean towards the plant diet.
      Having said all this I am still weighing my options. I dont find the need to kill another being to sustain me. Milk has produced various allergies leading me to belive I am one of the few who cannot consume/digest milk protiens well. There is only a small subset of people who really can do well with milk protiens and they are mostly caucasians. And I could go on. I know for those from the “protien” and “eat animal” camp will debunk my comment but I will weigh all information I read based on how my body reacts and will choose that is best for me. I was looking for a critique of / reference material used in the China Study before deciding if it is really valid; now after reading your commentary and reading your websites/background I think you are too biased to have an objective opinion.

  42. @ Brett, you seemed reasonably plausible, right up to where you touted Quackwatch. I’m sorry, that website is a good example of selective quackery. You won’t find a single expose of harmful medical or psychiatric practice on it, because that’s the built-in bias, and it’s surely a much greater bias than any you’ll find in Dr Eade’s work. In cases where I know significantly more about a subject than the quackwatch bloggers, I have found them to be dishonest. The experiments they cite in the Orthomolecular page, for example, bear no relation to orthomolecular theory or practice. Someone who didn’t know the truth might be inmpressed. The fact is, Quackwatch are shills for an nindustry that kills and mutilates unnecessarily thousands of people every year. What credibility can they have until they address the quackery under their noses? But if they told the truth, they’d be drummed out of their unions and lose the right to put all those letters after their names.
    You seem to ignore the “proof of pudding” evidence, that low-carb diets and dietary supplements are effective at controlling or preventing disease, according to us, the people who actually use them. We’re not about to change our minds because of any amount of evidence from rats, or any amount of speculative ad hominem criticism. “Only an idiot lets an expert contradict their own experience”.
    It’s a dirty trick to criticise Dr Eades for only making vague claims on his supplements, when you know full well that the law prevents him from refering to the truth, but that if you look in his books (or any biochemistry textbook) you’ll find the whole rationale. Do you educate the kids in your power to that ethical standard?
    I don’t know about the AHA but the New Zealand Heart Society is a joke. They put their heart tick on breakfast cereals which are 30% sugar for the reason that they contain less than 2% fat. And, of course, because the manufacturers support the Heart Society.

    1. Ditto re: quackwatch. Who’s watching the watchers?
      Bret lost a lot of credibility referencing the site.
      Thanks for pointing it out.

  43. I also want to step on the “change your mind publically” to prove you’re a scientist or something.
    Most doctors who profess an “alternative” idea have already changed their mind publically about many things. They have actually questioned the prevailing orthodoxy, found it wanting, assessed the evidence and re-aligned themselves.
    That’s more than you’re asking of the yes-men already.
    The other point is, that if Dr Eades or Dr Atkins or any low-carb proponent said “I was wrong”, they wouldn’t just be dismissing their own idea as false; they’d be rejecting the recieved view of mammalian metabolism that is contained in every biochemistry textbook. This is easy for mainstream nutritionists to do as they either haven’t studied biochemistry or don’t think it’s important. But they’re wrong, and any nutritionist who makes a serious study of what principles govern what happens to nutrients in the body – which has been well-understood for decades – is going to realise that mainstream nutritional practice is completely out of sync with mainsteam biochemical theory, and the latter is the hard science.

    1. Hi George:
      Thanks for your comments. I have a little time this afternoon (though not enough for a comprehensive rebuttal), so I thought I would respond to some of your statements. You are asserting a familiar position but are not making a good case, from my perspective, for any of your points. I’ll try to respond in the order you used in your post:
      1) “you touted Quackwatch” Please re-read my original post. I’m not touting anything, except perhaps the necessity of the careful study of primary sources. Quackwatch is not where you can do that, but the information there, in my opinion, is certainly more science-based than anything I’ve seen on Dr. Eades site. I am skeptical of any source or site and, as best I can, try to evaluate information in a claim-by-claim basis. Your claim that Quackwatch is a good example of “selective Quackery” is unpersuasive. “You won’t find a single expose of harmful medical or psychiatric practice on it” – I have to assume you have a different definition of medical practice than I do, or else this statement is a non- sequitur. Exposing harmful medical practices is the very reason for the site. Two examples addressed by Quackwatch are homeopathy and acupuncture. What on earth are you talking about? Based on what you wrote, it sounds like you are a proponent of orthomolecular psychiatry – I apologize if I’m wrong on that – and that this is what may be driving some of your own biases. To say the least, the general claims of orthomolecular medicine have not been scientifically proven. To say otherwise would simply not be true, unless you invoke a conspiracy theory (which you seem about to do with your references to you “knowing the truth”, and quackwatch doctors being “shills” for an industry).
      2) “I have found them to be dishonest” – another ad hominem. It is possible to be inaccurate without being dishonest. If the information is inaccurate, you can ask them to update it and provide more accurate information and references. The last part of the paragraph that follows this is a bit of an incoherent rant. You can be forgiven for ranting occasionally (this is a blog, after all) but it doesn’t prove any of your points. I suppose you could dismiss whatever I say by calling me a shill for big pharma, but it won’t support your arguments.
      3) “We’re not about to change our minds because of any amount of evidence from rats, or any amount of speculative ad hominem criticism.” I certainly believe you on this point. If your beliefs are unfalsifiable, then you have left the realm of science and there is no reason for further conversation. If what you’re saying is “We don’t care about the science (or science that doesn’t confirm our beliefs). It works for us. That’s our truth”, I worry about what happens next. Do you stop vaccinating your children because Jenny McCarthy says it caused her son’s autism? I hope not.
      4) “You seem to ignore the “proof of pudding” evidence”. Yes George, I do, because it’s not sufficient evidence. I repeat that testimonials are the weakest form of evidence (but the most seductive) and can’t be relied upon if you wish to make scientific progress. We can all be wrong, partly or wholly, about pretty much anything. We can all be fooled and bamboozled. Our best defense for this is the scientific method. The scientific method is how we painstakingly tease out the truth from half-truths and absurdities. When you abandon it and the critical thinking skills that it engenders, you are defenseless against the next alluring scam that comes along. You are welcome to keep all of your beliefs – just don’t call it science or be offended when someone points this out. If your claims are true, then they can be properly and scientifically tested and validated. At that point, I would be happy to accept those claims.
      5) “It’s a dirty trick” [ouch, George, why the ad hominem?] “to criticize Dr Eades for only making vague claims on his supplements” [nonsense – if he is selling a $100 bottle of supplements, he is the one who needs to provide the overwhelming evidence of its safety and efficacy] “when you know full well that the law prevents him from refering to the truth” [the main logical fallacy here is your unstated major premise, which I’m assuming (and forgive me if I’m wrong) is that you think there is a conspiracy to suppress the truth.], “but that if you look in his books (or any biochemistry textbook) you’ll find the whole rationale.” [huh? I’ve studied biochemistry. The “whole rationale” (as you describe it) is not in the textbooks. You need to be more specific with your claims.] “Do you educate the kids in your power to that ethical standard?” [I do the best I can – are you making a point or is this another ad hominem?]
      6) “I don’t know about the AHA but the New Zealand Heart Society is a joke.” That may be partly or completely true, but I was only referring to the AHA’s stated position.
      7) “I also want to step on the ‘change your mind publically’ to prove you’re a scientist or something.” This isn’t what I said. The question is whether someone has the courage to change their position, even their most cherished position, based on evidence. This is a common practice in real science, and a very rare one in alternative medicine and pseudoscience. Dr. Eades, I would suggest, has built his career and kingdom around his Protein Power diet. He has many adoring fans, and much invested (on many levels) in his position. If science was to show that the claims made by the proponents of this diet were false (for example, if his diet was shown to increase the risk of heart attacks or kidney damage in well-controlled, long-term studies), would he retract his claims and change his practice? In #3 above, your quote points to what usually happens in those sorts of situations. People are so tied to their positions, and so invested in their beliefs, that they can’t change, and so must either move the goalposts or look for other research (often inferior research) that confirms their beliefs. They drift further into pseudoscience. I don’t know if this is the case, or would be the case with Dr. Eades, but it is such a common human behavior that, at the very least, you should agree that we need to be vigilant about it happening to ourselves. It is very difficult to find anyone, actually, who at some point has not been guilty of some form of confirmation bias. I have done it myself many times. The glee with which I see people on this site pouncing on Dr. Campbell is one indicator, I believe, of an underlying confirmation bias. Dr. Campbell may have gone beyond the data in some of his claims (I honestly don’t know – I’m just saying it’s possible). The same could also be said for Dr. Eades, and the same can be said of your claims. If we don’t relentlessly use the error correcting mechanisms built into the scientific method (imperfect though our efforts may be), we will eventually all fall victim to pseudoscientific claims, which can cause real harm and suffering.
      8) “they’d be rejecting the recieved view of mammalian metabolism that is contained in every biochemistry textbook.” What on earth is this “received view”?
      9) “This is easy for mainstream nutritionists to do as they either haven’t studied biochemistry or don’t think it’s important.” Another zinger. Ad hominems mixed with cognitive distortions. This is the case for all “mainstream nutritionists” (whatever that is)? Every single one of them? They’re all either ignorant or they don’t think biochemistry is important? There are no other possibilities?
      10) “But they’re wrong, and any nutritionist who makes a serious study of what principles govern what happens to nutrients in the body – which has been well-understood for decades – is going to realise that mainstream nutritional practice is completely out of sync with mainsteam biochemical theory, and the latter is the hard science.” Is the acid test for completing a “serious study” of nutrition being in agreement with you? Nutrition, digestion, and the effect of diet on health really are complex topics. Here’s the bottom line: I don’t think the evidence is sufficient to say that low carb, high protein diets are even not harmful, let alone optimal for human health. As best as I can surmise, this is the general consensus of modern science at this point in time. If that changes, it will be because the accumulated evidence changes, not because a bunch of people beat up (metaphorically) T. Colin Campbell on the internet. The thing that bothers me most, George, about your response is the underlying contempt you seem to have for the everyday scientists, physicians, and nutritionists who do not share your position – as if they are out to intentionally mislead people or keep them from the “truth.” It is this casual assumption of moral superiority that I find the most discrediting to your position. I apologize for my frankness and I don’t mean to single you out – I see a lot of this same thing on most of the alternative medicine sites, such as this one. Thanks again for your comments, and I wish you good health.

      1. You’re an education administrator. If you want people to actually read through that TL;DR wall o’ text, white space and paragraph breaks work. So do fewer parenthetical expressions and em dashes.
        As for what part of your argument I can read without getting a headache, any topic that a layperson can form an opinion on will gain a following of idiots. It’s why I refuse to read the comments on Mark Sisson’s site, despite enjoying many of the articles. That site’s comments section is a an especially egregious example of self-congratulatory idiocy. The same attitude is found just about everywhere, as it is a problem with people, not the positions they defend.
        It doesn’t take being an “expert” in a subject to grasp underlying concepts. In the science of nutrition, however, much of the research is disconnected from that of its sister science of biochemistry, and our understanding suffers as a result. The unfortunate reality is that politics influence science, whether from confirmation bias or funding allocation. Until and unless a good deal of the political influence is removed from the field of nutrition, much of the data presented will be of questionable value, regardless of the conclusion. I wish I had saved an example of one of the many nutrition studies where the interpretation of data in the discussion section differs completely from the final results in the conclusion and abstract. I have been remiss in failing to document them, unfortunately. Gary Taubes’s book is an especially entertaining read, especially when it comes to documenting just how important social and political maneuvering is in the scientific community.
        TL;DR: Read more Thomas Kuhn.

  44. Thanks for the reply, Dr. Eades. I wish you addressed the tougher points I raised, rather than the “low hanging fruit” about my (admittedly incomplete) recollections of thumbing through your book years ago. The thing that struck me in that Evidence of the Pharaohs chapter is that you are suggesting that the actual Pharaohs (the rare people who got mummified) were the ones who consumed a high-carb, whole grain diet (rather than the common citizen (who weren’t mummified). Really? They were the rulers! They ate the most luxurious foods, including plenty of animal foods and sweets. It wasn’t a high-carb, whole grain diet. Look it up yourself or consult an Egyptologist. It’s a very basic thing, and I’m not sure why you don’t understand my criticism of that specific point.
    Your reply contained a few confusing claims (well, they confused me, anyway). Your assertion about “the ridiculousness of the mainstream nutritional advice – the advice to follow what is basically an ancient Egyptian diet” is a rather strange claim to make right after saying that the ancient Egyptians lived “before sugar, as we know it” and “consumed a high-carb, whole-grain diet”. I guess I’m not getting it. Mainstream nutritional advice is to eat no sugar but have a high-carb, whole-grain diet? The ancient Egyptians “suffered from all the medical conditions – heart disease, diabetes, obesity and probably high-blood pressure – that people do today” on this sugar-free, high-carb whole-grain diet? The people today who have those diseases, they are following a sugar-free, high-carb, whole-grain diet? Or are they also eating a diet high in simple sugars and refined carbohydrates? Can you see why this is confusing? Remember, I’m not accepting your claim about the Pharaohs. The fact that the extremely small cohort of well-fed prosperous, later-to-be-mummified rulers of Egypt had heart disease, diabetes, obesity etc. is no surprise given that they could eat and have access to just about any food they wanted, in abundance. We don’t really know, however, exactly what they ate every day, though I’d be more than surprised if it was a purely sugar-free high-carb, whole-grain diet. In such a small sample size, with uncontrolled variables, I just can’t see any merit in this as an example. Perhaps in the rest of the chapter, you had some better points. However, your argument is only as good as the weakest link. I continue to maintain that this is less than a very weak form of evidence for your hypotheses.
    You’re right about another part of your reply – of course I didn’t read “The Covenant with the Wild”. I thought it was clear that your recommendation of the book was the part that I found offensive and served as an absolute disincentive to reading it. It really has nothing to do with anything in the book. Really, the suggestion that, by reading some book, you could disabuse people of what is (for many) is the most fundamental reason that they are vegetarian is so dismissive of their deeply held beliefs, it is insulting. I can believe you if you say that the slight was unintentional on your part, but you should at least be able to see why people would find this offensive. Rather than saying that I have totally mischaracterized you (the easiest defense of all), why don’t you address this point with at least some substance? If we are able to put aside any ethical objections to consuming increased amounts of animal foods, it sure makes it easier to promote a high protein diet. But putting these objections aside is not something that is easy to do, or that you have been able to do – and certainly not by casually offering up another book to read. That suggests that you think your vegetarian readers haven’t examined the issue deeply already (at the level of, for example, the work of Peter Singer). You seemed to say, “Read this one book, and the ethical issues around consuming animals, you will see, will no longer be an issue for you.” Please, I’m not interested in mischaracterizing you – and I’m sure a lot of vegetarians would appreciate a more thoughtful response from you – so feel free to set the record straight here. And if you could address some or any of the other points I raised, it would certainly be of interest to skeptics of your work. Thanks again for taking the time to read and respond to my post.

    1. I’m sorry you feel my arguments are less than compelling. But I’m afraid you’ll have to take them as they are.
      I argue most of my cases fully throughout this blog, and I typically go into great depth. My full arguments over the issues that are of concern to you are here if you choose to search for them.
      I view this blog as my living room, a great room into which I invite anyone who wants to come and listen to me expound on whatever it is I feel like expounding on. I try to be a gracious host, and I expect my guests to be gracious as well. And I’ll tolerate polite dissent and polite argument over the points upon which I expound. But, in the end, it is my living room where you and anyone else is invited at any time, and, as such, I’ll decide on which arguments to deal with head on and which to ignore. If I choose to ignore good and rational arguments about the points I’m trying to make, the guests in my living room may find me shallow and leave so that I find myself talking to no one. That is my risk in ignoring specific arguments.
      But, I sense that you are an ideological vegetarian, and if so, no amount of reason and argument on my part will persuade you that you might be incorrect. So, since I don’t enjoy tilting at windmills, I’m going to withdraw from this one. If you can give me specific evidence that, if true, would dissuade you from your point of view, then I may try to provide this evidence. But I’ve been around far too long to get myself stuck in the an interminable discussion that ends up leading nowhere.

      1. Dear Dr. Eades:
        Thanks for allowing me into your living room for this brief visit. You have been a gracious host. And I understand that you prefer that I now leave.
        “But, I sense that you are an ideological vegetarian, and if so, no amount of reason and argument on my part will persuade you that you might be incorrect.” Sorry, though I don’t know precisely what you mean by “ideological vegetarian”, I can assure you that I am not that, and that I will change my mind when presented with good scientific evidence.
        Where’s the “reason and argument” piece, by the way, on your part, in our recent dialogue?
        “If you can give me specific evidence that, if true, would dissuade you from your point of view, then I may try to provide this evidence.” Sorry, this is awkwardly worded. If what you are asking is “What would convince me that the Protein Power diet is safe and effective?” then great! Here is what I would want to see:
        – Properly designed and controlled scientific studies that show there are no long-term negative health effects of this diet
        – Properly designed and controlled scientific studies that show this diet significantly improves weight loss over a long period of time (five years seems to be a reasonable number).
        – Properly designed scientific studies that predict that this diet, if adopted by a majority of the world’s population, will not have a negative effect on the environment
        – Properly designed scientific studies that predict that this diet, if adopted by a majority of the world’s population, will not have a negative effect on the health and welfare of animals.
        “I’ve been around far too long to get myself stuck in the an interminable discussion that ends up leading nowhere.” Absolutely. I completely understand where you are coming from here. Thanks, and I wish you all the best.
        Brett Raycroft

        1. You wrote:

          Thanks for allowing me into your living room for this brief visit. You have been a gracious host. And I understand that you prefer that I now leave.

          That is incorrect. I don’t prefer that you leave. You may stay as long as you like. I’ve noticed that many other readers have engaged with you, and that is fine. I just don’t have the time myself to engage in a debate that is likely to go nowhere.
          As to your criteria as to what would make you change your mind…you’ve set a pretty high bar. One that any diet you may be in favor of certainly couldn’t meet.
          Interestingly, in view of this conversation, here is a study that just came out today in the venerable Annals of Internal Medicine. It’s not a five year study, but it is a two-year study, which is about as long as the longest dietary studies (that aren’t observational studies) go. You may not know all those doctors and researchers in the list of authors, but I do, and virtually all of them are believers in low-fat diets. Must have been a bitter pill for them to have swallowed when the data came in.
          Again, please feel free to hang around. My intention is certainly not to drive you away.

          1. Thanks very much, Dr. Eades. I appreciate that the door is still open. To be honest, though, the room doesn’t look as inviting if you’re not going to engage in a substantive dialogue on the points I raised. I respect your right to do so, however, and wish you well in the future.

      2. Sorry, but I have a last comment. By your response, you are saying that you are not a scientist. That’s okay! But please be honest about it.

        1. You claim to be a biologist. You claim to require solid, irrefutable evidence to change your diet. You follow a diet that does not have solid, irrefutable evidence to support its adoption.
          What conclusions can we draw from this?

  45. Brett picked up Dr.Eades’ “Protein Power” in a bookstore and quickly made up his mind that the book was no good. He writes:
    “You suggested that since the Egyptians ate a lot of bread, and the mummies of Pharaohs revealed that they had lots of health problems, therefore high carb diets caused those health problems. This is probably the worst example of evidence, coming from a doctor, I’ve ever heard. AS IF PHARAOHS ATE THE SAME THING THAT THE COMMON PERSON AT THAT TIME DID.” (emphasis added A.B.)
    I have checked the relevant section. In fact the word pharaoh is not mentioned once there. Dr.Eades talks about mummies in general and states that the
    ‘number of mummies … has been estimated by some experts to equal the population of Egypt today.’ Does that suggest that we are exclusively dealing with pharaohs here?
    One can indeed assume that, generally speaking, mummies are the remains of people who were better off and had therefore perhaps greater access to relatively expensive protein than the common folk. However, we are assured that the bad sieving methods of flour used for bread left flakes of stone and sand in it and that this caused an abrasion of teeth, from which all classes seem to have suffered (the remains of Amenhotep III provide a notable example here). In other words the consumption of bread seems to have been widespread (see http://www.reshafim.org.il/ad/egypt/timelines/topics/bread.htm).
    Brett seems to be eager to find his way among the conflicting diet advice. May I suggest that careful reading is the prime requirement here? He also holds it against the low-carb adherents that they act against the advice of ‘mainstream science’. But it was ‘mainstream science’ that saddled us with the ‘food pyramid’ and after (careful) reading of Gary Taubes’ magisterial ‘Good Calories Bad Calories’ concerning the ‘scientific’/political background of that piece of misguided advice I lost all trust in ‘mainstream science’ on this point. Did Brett encounter that book or did he pick it up, like Protein Power, in a bookshop and reject it after (mis)reading one paragraph?

    1. Thanks very much for your comments. I appreciate that you engaged less ad hominems than usual for this site 🙂
      “‘number of mummies … has been estimated by some experts to equal the population of Egypt today.’ Does that suggest that we are exclusively dealing with pharaohs here?”
      Okay, fair enough. Could you please tell me what is the size of the cohort group of mummies for which these dietary claims have been made, and what did they eat that that caused their health problems? I will retract my criticisms if this turns out to be a large, homogenous group for which the usual variables have been controlled.
      “Brett seems to be eager to find his way among the conflicting diet advice. May I suggest that careful reading is the prime requirement here? He also holds it against the low-carb adherents that they act against the advice of ‘mainstream science’. But it was ‘mainstream science’ that saddled us with the ‘food pyramid’ and after (careful) reading of Gary Taubes’ magisterial ‘Good Calories Bad Calories’ concerning the ’scientific’/political background of that piece of misguided advice I lost all trust in ‘mainstream science’ on this point.”
      Thanks for the advice about careful reading. I’ll do my best to follow it.
      I’m sorry to hear that you have lost all your trust in mainstream science. Does that mean that you don’t vaccinate your children, drink the water from your tap, drive a car, talk on your cell phone, or use your computer?
      Though I don’t know about Gary Taubes work, what I will say is that many errors have been made in the name of science, but that the scientific method contains, within it, error correcting machinery which, if utilized, reduces the error bars with each successive generation. Our generation, thanks to the progress of science, has addressed many of the challenges that our parents and grandparents faced. One of my sons has Type I Diabetes. He would have died an agonizing death years ago without the interventions of modern science.
      “Did Brett encounter that book or did he pick it up, like Protein Power, in a bookshop and reject it after (mis)reading one paragraph?”
      Thanks for the ad hominem. As a parting request (Dr. Eades would rather I not contribute anything further to his blog), could I suggest that you might be a bit more friendly to those who do not support the specific claims that support your hypotheses?

  46. Brett, once again please read carefully. I didn’t write that I had lost all trust in mainstream science in general. I said ‘on this point’ that is as far as diet matters are concerned. You quoted it and then chose to overlook it.

    1. Is there a familiar ring to any of this?
      “Barrett is a shill for the medical and pharmaceutical cartels and his bully tactics and unjustified discrediting of leading innovators, scientists and health practitioners should not be tolerated.
      Negrete said, “You can be assured that our legal team will be wherever health freedom advocates and practitioners are being persecuted. The tide is now turning and people are no long accepting that synthetic drugs are the only form of treatment are the only way to address health concerns.
      Every day, consumers are becoming more educated about the benefits of holistic and alternative methods. This is something that the medical establishment obviously fears and wants to crush with false propaganda.”
      Case closed. Thanks for providing the link, Jeanne. Take care, good luck with your Mac, and try to drink the Kool-Aid in moderation.

      1. “…and try to drink the Kool-Aid in moderation.”
        Would you describe this as an ad hominem attack? Curious.

        1. Yes, it is an ad hominem attack, as it is comparing the original poster to a suicidally devoted cult member.

    2. Hi Arie:
      You’re 100% right. You did say “on this point” in your original post. I’m very sorry that I overlooked that – it wasn’t intentional. Thank you for correcting me.

  47. I think one important issue raised here is “I find all of the mudslinging back and forth between high protein and low protein proponents tiring and unhelpful…. I wish I knew who to trust with nutritional advice. A lot of people, yourself included, seem able to peruse the literature and cherry-pick studies that support your hypotheses. …Who has the courage to change his or her mind, even if it is publicly embarrassing, based on new evidence (or a closer look at the existing evidence)? …. Who can you trust?
    For a start, style is important. Unrestrained, even ad hominem attacks are ok in your friend’s living room (I envision a SousVide prominently displayed like a sculpture, the Colpo dartboard pretty much reduced to shreds) It is also Ok in a blog (I think that’s what blogs are for). When you put them in a scientific paper or a book that is supposed to be a scientific argument, that’s a really bad sign. I haven’t read Campell’s book. It certainly sounds like it has some devious arguments but I am of the opinion that if a diet works for you, go for it. (Mike and I disagree on this — he thinks carb restriction is almost always best and we have compromised with the principle: there is no reason you have to be on the very best diet). It is the unrestrained attack on Dr. Atkins that makes you think twice. Now few are as tasteless as Mike Lean who wrote a “scientific” article called “Is Atkins Dead (Again).” Even lawyers are considerate of widows. So protesting too much is one sign.
    All literature citations are cherry-picked. It is a question of how tart the cherry is. That is why when I referee a review article, I ask the author to include graphs or other data from the original source rather than just citing the conclusion. If the author can’t do that, that is not helpful and may be suspicious. I am sympathetic about how much work it takes to find enough clear information to make a decision but there are some guidelines to reading the original literature. One is whether the data is clearly presented in understandable graphics. If the paper is all tables in a dense, mind-numbing format, the author, at minimum, has not learned his trade: make the data accessible to the reader.
    More on this, later. I think I am preparing a guide to reading the scientific literature.

    1. I would say that some people tolerate carbohydrates better than others. Many people smoke and live very long lives (Picasso and Winston Churchill come to mind), but that doesn’t mean that everyone should be encouraged to smoke. We don’t know – but we can reasonably believe – that the long-lived smokers would have lived longer or been in better health had they not smoked. In my opinion, it’s the same with carbs. Just because some people seem to do fine on them doesn’t mean these people are doing optimally or that we should use them as examples to promote carb consumption for everyone. Or even anyone.

    2. An excellent and insightful post, Richard. I’d be interested in reading your guide when you have prepared it. Thanks for your observations.

  48. First of all you and your wife are my heros along with my brother who got me to read ‘protein power’ in the fall of 1999. That book along allowed me to basically and effortlessly lose the 45 pounds I needed to lose, from195 to 150 in five months. There is absolutely nothing more exhilarating than to do something for your health and find it works meaning you have found or been given the key to health. Atkins is another favorite, bless him too.
    But it is shameful for studies that you critiqued to be allowed into the public’s hands, one for promoting the wrong way to eat and two, to enhance the fortunes of the carb industry, which I have come to realize, not just by reading taubes’ ‘good calories – bad calories’ but just experiencing the marketing of those really nasty things people are convinced are healthy foods, especially children. Maybe one day all lobbying will be outlawed and someone like the fda will truly regulate the food industries.
    Thank you and your wife for your ‘protein power’ and ‘proteinpower life plan’.

  49. Brett,
    I have noticed in your posts a certain idealized concept of medical science and the scientific method, which at times in my opinion, was a way more lofty view of science than actually exists in reality. It is understandable that a non-scientist would expect this of science, medical science and the scientific method. Most expect it when exposed intellectually to its tenets of precision and control. But its implementation is usually different, especially as it relates to the difficulty of controlling variables in human studies, and what is often yielded in even the most carefully designed study is more gray area than black and white. When, then, studies do not have careful controls, what you usually get is a complete mess, and unfortunately there is a lot of mainstream medical research that falls into this category.
    I received my graduate scientific training at the University of Colorado in exercise physiology under the tutelage of some of the best brains in this field. They were so concerned about this problem of bias in medical research that they drilled us in skepticism constantly. Not to worry about what the homeopaths or the accupuncturists or anybody else was doing, but to first and foremost be skeptics of what was happening in the fields we were gong to be responsible for: metabolic biochemistry, exercise physiology and the diseases of civilization. We were regularly huddled into viewing this film or that presentation on the mischief going on in medical science. We were required to regularly give presentations ourselves on sections of big review articles, analyzing the research cited by those sections to see how well it supported the conclusions made by the review – it often did not. We were required to review studies that did not get published because their findings did not yield statistical significance, an extraordinarily important thing to know but rarely disseminated into the professional literature. And our own work, our thinking and our assumptions were relentlessly critiqued. One entire day of my comprehensive final exams was devoted to analysis of research design and statistics. It was that important to them that the only thing that impressed us was a deep analysis of the actual data. Good training in the medical sciences yields skeptics of medical science.
    Therefore, you have clinical professionals like Dr. Eades and Dr. Feinman [and Dr. Atkins and many, many others both from clinical practice and academia] who take everything with the requisite grain of salt in the fields for which they have responsibility. It would be one thing if the messes of medical science mentioned above kept to themselves, but they do not. Many of these messes have found political favor over the years and have found their way into public health policy which many of us feel, with good evidence, have contributed to the escalation of disease, not the remediation of it. When you treat patients who have been “following the guidelines” and are becoming sicker, the responsible thing to do is to question the guidelines. I cannot speak for Dr. Eades on your assertions of ad hominem, but I can relate my own frustration and anger as an advocate for sick patients who keep trying to do what they’re told, which is the same thing over and over again, and keep expecting different results; i.e., success with their health. When another crappy piece of research like The China Study is widely disseminated, it further indoctrinates the bias into public health policy that a particular diet is good for everybody, when there is good research that shows it is not.. And I, for one, get pissed off about this on behalf of my sick friends and family, and the sick patients that I work with, all of whom keep trying to do the right thing and who believe our mainstream nutritional research must have the best credibility for guiding them. Just possibly Dr. Eades and others feel the same..
    When you have the “inside baseball” view, you must further address the issue that analyses of the data in The China Study do not even support many of the conclusions and assertions the authors make about the data, and some of their results could be explained by other things than what they conclude. And that is Ms. Minger’s point in her analysis, and the problem I had when reading the book. Like her, I kept asking out loud, “but what about *this* possible confounding variable?! And what about *that* possibly confounding variable?!” These scientific questions are sometimes addressed, but mostly not. Yet this problem doesn’t stop them from concluding that it’s the “most comprehensive study on nutrition ever conducted” and better you to listen up and follow along.
    The issue of confounding variables is huge in human research. A perfect example is from today’s news, a new study which analyzed a group of studies on calcium supplements and showed that overall there is an increased incidence of heart attacks among subjects taking calcium supplements. Headlines everywhere today read, “Calcium Supplements Linked To Heart Attacks”. If you look at the actual data, however, what you find is that in the 15 studies reviewed in this meta-analysis, half of them included subjects who already had heart disease and most of the rest of the studies did not have information available whether or not there was pre-existing heart disease in their subjects. As all studies had an inclusion criterion that subjects needed to be over the age of 40 [and therefore at risk for osteoporosis], one can guess that there were also subject with heart disease in the studies that did not indicate heart disease status.. So it needs to be asked, did the calcium supplement increase their risk for heart attack or did their existing heart disease increase their risk for heart attack? Brett, what do you think? Do you think this mainstream scientific paper, published in the prestigious British Medical Journal, is above reproach?
    I felt mostly, Brett, that you were sincere in your quest to trust and I understand the upset that people feel when they cannot rely on things that are personally important to all of us. And I do sympathize with your correct assertion that scientific arguments can become all about who’s got the bigger pile of papers to support their point of view. But that’s kinda how the discipline moves forward, and ends up doing good things too, like finding effective treatments for your son’s diabetes. I would have appreciated your comments more though, had you not mischaracterized Dr. Eades points on several occasions, not the least of which was to assert in the end that he didn’t want you posting more, when he said just the opposite. I hope that Dr. Feinman does write a guide on how to read a scientific paper. It would help a lot of people like you who are attempting to find the truth for themselves.

    1. Thank you very much for your lengthy and thoughtful comments.
      “a certain idealized concept of medical science and the scientific method”
      Prior to this week, I haven’t been called idealistic in a long time – it’s kind of nice! I do understand the difference between how science should be done and how it is done, but I appreciated your perspective.
      “Brett, what do you think? Do you think this mainstream scientific paper, published in the prestigious British Medical Journal, is above reproach?”
      If you’re asking me this question, you certainly didn’t understand my stance about science and the scientific method.
      “I would have appreciated your comments more though, had you not mischaracterized Dr. Eades points on several occasions, not the least of which was to assert in the end that he didn’t want you posting more, when he said just the opposite.”
      On the contrary, he said the following, prior to me saying that:
      “I view this blog as my living room, a great room into which I invite anyone who wants to come and listen to me expound on whatever it is feel like expounding on. I try to be a gracious host, and I expect my guests to be gracious as well. And I’ll tolerate polite dissent and polite argument over the points upon which I expound. But, in the end, it is my living room where you and anyone else is invited at any time, and, as such, I’ll decide on which arguments to deal with head on and which to ignore. If I choose to ignore good and rational arguments about the points I’m trying to make, the guests in my living room may find me shallow and leave so that I find myself talking to no one. That is my risk in ignoring specific arguments.
      But, I sense that you are an ideological vegetarian, and if so, no amount of reason and argument on my part will persuade you that you might be incorrect.”
      He didn’t use the words “go away” there, but that was certainly the message I was getting. If you think I’m mischaracterizing him, that’s okay. But he has chosen not to address my points, and told me that he wouldn’t do so in the future. And that I’m an ideological vegetarian (whatever that is). And that no amount of reasoning will change my mind. All real helpful stuff, I’m sure, but not exactly a welcome mat.
      His bottom line, “So, since I don’t enjoy tilting at windmills, I’m going to withdraw from this one” is certainly his right, but is for me unenlightening and leaves me with the same questions I came here with.
      Thanks again for you comments. You seem to be a thoughtful and decent person and I have no enmity with you around any differences in our viewpoints. I can say the same about Dr. Eades. All the best.

      1. Dr. Eades’ said, “the guests in my living room may find me shallow and leave so that I find myself talking to no one”.
        You say you interpreted his words to mean “go away”. I’ve been reading Dr. Eades’ for several years now and my interpretation to his words was more like readers can always chose to go if they don’t find value in what he has to say.

    2. Wow, LC! I found myself cheering and saying, “yep, yep, that’s it, uh-hunh, exactly!” Thanks so much for putting into words so many of my thoughts and feelings. I try to tell my wife and my family not to worship science, scientists and doctors. They are human, just like us. They only know what they’ve been taught and what if the information was wrong? Etc, etc. I copied your comments into a Word file so I can read them again and again and share them with my friends, family and clients. Thanks so much for taking the time to document your experience!

  50. Dr. Eades, it’s good to see you bringing this up, though I would note that you’re rather late with this information. Campbell’s book has been quite influential, and one of the first things people did was analyze the results and find just how distorted his conclusions were. For example, here’s a random Amazon comment that did multivariate analyses that showed that based on the actual data, it’s plant protein, not animal protein, that predicts heart disease:
    In univariate analysis, it is wheat that most strongly predicts heart attacks:
    Campbell has been practicing his “it was only one chapter” response to the fact that his results are contrary to the actual China study data since at least 2006:
    http://www.vegsource.com/articles2/campbell_china_response.htm (third paragraph from the end)
    Finally, yes, the actual Chinese data is all correlations rather than direct proof of causations. However, correlations can be useful in identifying possible theories of causation – as well as ruling them out. Sometimes it’s all we can get. Viewed with skepticism and an open mind by someone familiar with statistical analysis techniques, I think there is value to going through the Chinese data.

    1. I guess I was a little late to the party, but as I mentioned in the post, all the analyzing of his data is for naught. It’s all observational data and worthless for proving causation, so I lost interest. It was only after I read the book The China Study that my blood got up.
      On another interesting note, Campbell makes the claim in The China Study that there are over 8,000 statistically significant correlations in his China study data, which is really meaningless because statistics aren’t science and correlations don’t prove causation. But he has 367 variables, each of which he compares and correlates to all the other variables. That gives (367 X 367) 134,689 possible correlations. Most statisticians use a 5 percent confidence interval to determine statistical significance. If you multiply the 134,689 by 0.05 you get 6,734 ‘statistically significant’ correlations that would occur just by chance, which is damn close to the 8,000 he’s crowing about.

      1. I have been thinking about starting a movement to ban* correlation studies, much like chemical weapons. Sure, it would reduce the total amount of human knowledge.
        But at the same time, if would hugely diminish the amounts of bogus findings in ‘dense-causality’ fields.
        I have run some regressions myself, if nothing else it can be useful as a reality check. Especially as a reality check on strong assertions.
        This is why Minger´s analysis matters somewhat. Campbell implied that there were correlations present, that… well, weren´t there at all. That´s a pretty big reality check, if nothing else on the credibility of Dr Campbell.

  51. Dr. Eades, allow me to encourage you. In 1999 I was in very bad shape. If I remember correctly, I heard about Protein Power from you on one of those Sunday-morning radio infomercials. I weighed 253 (5’11”), and had high blood pressure which I had just started taking medication for. My doctor wanted to put me on Statins for elevated cholesterol. I told him, give me a few months to try something before we do that. I got your book, Protein Power and then sent away for the kit. Do you remember the kits? LOL. The one with the cassette tapes, the VHS tape, and the carb wall chart, etc? Anyway, long story short, lost 77 pounds, down to 176, cholesterol down a little but HDL at 63 and triglycerides at 29! My doctor was stunned. He asked me how I did it. My next visit I gifted him with a copy of Protein Power Lifeplan. On my next visit he told me that he was recommending it to his patients. You saved my life. I will be eternally grateful to you for that. Also, because of you, I am changing occupations (my old AA’s in Computer Technology and Computer Information Science are just not getting me a good job like they used to and I’m 56). I am currently working on my exam from ISSA to get certified as a Senior Fitness Specialist. In a couple of weeks I start my classes at the community college to earn a two-semester certificate as a Fitness Specialist which will prepare me to take my Certified Personal Trainer exam from ACSM. So, you see, Dr. Eades, you touched my life and now I will touch dozens, maybe hundreds more, and how many lives will they touch? Thanks for taking all the crap that comes your way from all of us you are helping.

    1. Terrific! MD and I love stories like yours. Thanks very much for writing and keep touching others’ lives.

  52. Comments on scientific method: I’ve worked in a number of scientific fields: as far afield from my training in enzyme chemistry as behavioral neuroscience but I have never seen all of this levels of evidence, principles of science, etc. that get discussed in medicine. I probably posted my Mozart story before so won’t again unless somebody wants it.
    Science is a human activity and nobody really has a definition. In the end most scientists agree with Justice Stewart’s take on pornography, that they know it when they see it. I do like the definition from a neuroscientist at the NIH who said “what you do in science, is you make a hypothesis and then you try to shoot yourself down.” That, for example is what’s wrong with the Foster paper that just came out. Foster said in public that he set out to trash, an attitude maintained at least by all the other authors on the paper.
    So, I don’t think there are general definitions. For example, I don’t think there is a clear difference between observational papers and any other kind. Astronomy is all observational. It is what the observations are and, if there are correlations what the strength of the correlations are and how consistent they are with known mechanisms. For whatever reason, I am dealing with Djousse’s paper (Diabetes Care 2009, 32(2):295-300): Egg consumption and risk of type 2 diabetes in men and women. The conclusion is that the hazard ratio for diabetes and > 7 eggs per week is 1.58. What’s wrong with that (the failures of method I can describe later if anybody cares) is that a hazard ratio is similar to an odds ratio which is pretty much what you think. Should you bet at this blackjack table or that one. Well, 1.58 might be enough to make a decision on if you were going to sit at the table all day but if you place one bet it doesn’t tell you anything. And if you bet on low eggs and lose, you will get diabetes. You don’t get your chips back. For comparison the hazard ratio for lung disease and smoking, I believe is about 22 (number off the top of my head). Also — not an expert on this — I think to introduce scientific evidence in a toxic court case, you need a hazard ratio of at least 2. Associations don’t imply causality if the association is weak.
    If the association is strong, then it does imply causality. The cigarette example is a good one. Of course, you can never prove causality, only consistency. You can only disprove causality. So what is the deciding factor. Well, strangely believe it, common sense is part of scientific thinking.
    There is also the consistency with effects of cigarette smoke on lung structure and function. So what’s wrong with eggs and diabetes is there is no mechanism and it just doesn’t make any sense.
    My thoughts for now.

  53. Would or would it not be a major part of determining the effectiveness of diet and health to measure or detect, what I read in Taubes’ ‘Good Calories…’, this condition of ‘internal starvation’ by the overriding of stored fat as cellular fuel by insulin when carbohydrates are the major provider of fuel to to cells, I think in the form of glucose?

  54. @ Brett, yes I probably have a book in me, but I’m not about to write it in the comment space on the bottom of someone else’s blog. Most of the questions you ask of me you could easily answer yourself. You make a point of misunderstanding me, but I’d be a fool to try to clarify most of those points. I guess that’s the Socratic method, and much good it did him. As for the ad hominem tag – you can dish it out, but you can’t take it.
    You are, sad to say characteristically, being obtuse about Quackwatch – I can’t believe I have to spell this out – Quackwatch, despite the name, does not address the egregious abuses of MAINSTREAM quacks. That is a credibility gap I cannot cross. The drugs that kill, the operations that main, the psychotherapies that destroy the chance of happiness. Do you think it’s not quackery if it’s approved by the FDA? Barrett and co. do.
    The “proof of pudding” argument; I accept no man’s testimonial as proof. But I do trust my own experience. Most of the things you question here you can more-or-less easily verify for yourself. You don’t have to accept handed-down rules from god-like figures from on high – it’s DIET f’chrisake, eating, something everyone does every day – no-one has a monopoly on the experiment.
    The claim about biochemistry texts is not a figure of speech, not even hyperbole. I quote from a passage I found at random last night;
    “It has long been known from feeding studies that dietary cholesterol efficiently suppresses the endogenous synthesis of cholesterol. This control occurs at both transcriptional and translational levels, with cholesterol itself or one of its derivatives playing an active role in translational control. In addition, the enzyme [HMG-CoA reductase] is regulated hormonally, by insulin and glucagon”
    from Biochemistry 3rd Edition, Mathews, Van Holde, Ahern.
    There are two consequences of this; there is no advantage to low-cholesterol eating, and endogenous production of cholesterol can be altered by manipulating the insulin – glucagon balance, insulin being produced in response to carbohydrate. As far as other aspects of the lipid profile go, the role of niacin in elevating HDL cholesterol and lowering LDL and serum triglycerides was discovered by Abram Hoffer in the 1950s, and his ongoing work with niacin, ascorbic acid and hallucinogens led to the discovery of othomolecular psychiatry. One of the many reasons I support orthomolecular medicine when I get the chance is that, when I was much younger, I was called on to use gram doses of niacin and vitamin C to help someone who had overdosed on psilocybin, and the result was a spectacular restoration of normal sanity. I tell you this not because I expect it to convince you, but because anyone might find themselves in a similar situation.
    What really matters is helping people to live better lives, not convincing the sceptics.
    If you look further into Dr Eades writing (e.g. the “Man the Hunter” excerpt in this blog http://www.ofspirit.com/tw-theproteinpowerlifeplan.htm) you’ll find that he does treat vegetarians too, with a vegetarian diet. It’s just easier to eat low-carb with a fuller dietary range.

  55. Hi
    I know its not related to this post…
    I just realized that there are some errors in the Fats and Oil section in your PPLP Gram Counter book, for example: Canola 1 Tbsp (which is 14 gram) has 20.3 grams omega 6 and 9.3 omega 3 (page 26) and so are most fats.

  56. I think that disputes like this have more to do with philisophical viewpoints than they do with assessing the evidence. Some people take the POV that we can’t know reality, we can’t trust our senses or judgement and make decisions for ourselves, and they end up, by choice or by default, going along with what insitutional authorities decide for them (or rebelling against it in an equally non-selective fashion).
    And others, and I would be one, say that man can know what is real and true for all practical purposes; that if we eat the right food, use the right supplements, and practice the right mental disciplines to learn from our experience we will eventually develop the intelligence we need to decide for ourselves who is right and where even they may be going wrong. We cannot prove we are right to people on the other side of the philosophical gap, but we can say that what we experience FEELS like health; it is the opposite of depression, for one thing. Schopenhauer found it rational to be depressed, and he made a good case, but I think the depression came before the rationalisation.
    To someone of the opposite persuasion, Dr Eade’s material success (and I am sure Brett exaggerates it) is cause for celebration, not resentment, because it provides proof that common sense that goes against the grain of lazy thinking can be rewarded in this life.
    I’ll define mainstream nutrition for Brett; a food pyramid which has “whole grains and pasta” at the bottom with “eat most” and meat, cheese and fish at the top with “eat least”, advice that you’ll get all the nutrients you need from an “average healthy diet” or some such meaningless formula, and the assumption that when you get sick (and you probably will) there’s nothing you can do but see your doctor and take whatever they give you, because nutrition has nothing significant to offer you. There are alternative viewpoints, but they’re considered “alternative” viewpoints.

  57. There was a comment posted on Denise Minger’s website suggesting that perhaps Gary Taubes should write an article for the mainstream press like the NY Times about how Denise Minger took on Campbell and his China Study. I think this is a good idea and hope that you could suggest this to Taubes. This will bring even more publicity to Minger’s efforts to critically review Campbell’s results and conclusions and once again show how bad science occurs when biased researchers highlight positive results that support their favorite hypothesis and predetermined conclusions while ignoring data and results that do not.

  58. Agreed on the statistical significance. With this many variables, one should start with a higher bar than p < 0.05. For example, it's interesting to note that a lot of the correlations with p < 0.001 are also associated with latitude, which is suggestive.

  59. For what it’s worth, I tend to credit the calcium analysis, which is supposed to be from placebo-controlled trials only. If people with age-related disease are only given calcium, and not vitamin D, magnesium, K2 etc, I would expect these results in some. They were deserving of better care. Here are my reasons – 1) the gut has a limited ability to absorb ionic minerals, and large amounts of calcium reduce absorption of magnesium, zinc, manganese and other minerals. 2) low blood levels of calcium are compensated for by activation of vitamin D3 to 25-hydroxy D3. This promotes retention of calcium in the kidneys. The more calcium in the blood, the lower the level of this form of vitamin D, which is the vitamin D metabolite associated with decreased incidence of many age-related diseases. 3) magnesium is required for the conversion of D3 to 25OH D3, and is also a vital electrolyte in maintaining heart rhythm; magnesium levels are often sub-optimal. 4) if vitamin K2 is sub-optimal (as in a low-fat diet) calcium is more likely to be laid down in the blood vessels instead of the bones.
    In fact the body has intricate systems for balancing calcium when intake is low. Osteoposoris is not always due to deficient dietary calcium but may be due to hormonal factors, or deficiency of vitamin D, magnesium, or other bone-building factors. If so, supplementing calcium alone may not help, or even make these problems worse.
    So I tend to agree with the study not because it was infallibly “scientific” but because there is a clear mechanism to explain the result.
    However, I think it only noted heart attacks, not death from heart attacks, and it ignores other common causes of death such as cancer. So, by itself, it does not tell you whether supplementing calcium is a good idea or not.
    Dr Eades, I also think you are wrong to fault Campbell for insisting on the observational “shotgun” method. It is his analysis and bias that is wrong. All forms of evidence are valuable and contribute to proof. The current fashion is that the randomised controlled trial is “most scientific”, but the fact is that if you had a RCT that “proved” something and all the anecdotal evidence was opposed to it, the RTC would probably be wrong. It is when anecdotal evidence (including case histories as well as testimonials), observational studies and RTCs agree that you can really claim to have proof of something. Correlation is not causation, but you cannot have causation without correlation.

    1. I agree with your last paragraph, sort of. I do believe that observational studies are important; observational studies demonstrated the huge negative health impact of smoking on humans. The problem I have is when people who should know better use observational study data to persuade those who don’t know better that there is causation.

  60. All forms of evidence are valuable and contribute to proof – even the ancient Egyptians. 😉

  61. First off what a great treasure I’ve found in this blog. So much information in one post I’ll have to dedicate a week to just tracking down all the specific references made here.
    Secondly I’m wondering more and more about why we have to keep doing diet studies on rats? I know I know. They’re cheap and easy to breed and we can do this all day.
    But what good is it if their metabolisms are almost opposite of ours? So frustrating to read study after study about rats. It would be like reading a study about cancer in horses and then trying to apply that data to fish! *actually on second thought that might be pretty relevant in comparison to rats and humans.
    Thanks for the great blog and all your great work, doctor!

  62. “Though I don’t know about Gary Taubes work”
    “Good Calories, Bad Calories” is one of the most important works of our era and should be required reading for anyone who wants to discuss nutrition & metabolism in any meaningful way.
    1. “- Properly designed and controlled scientific studies that show there are no long-term negative health effects of this diet”
    In the 1970’s the McGovern commission and it’s results essentially sent Americans on a 30+ year “experiment”. Look where we ended up.
    2. “- Properly designed and controlled scientific studies that show this diet significantly improves weight loss over a long period of time (five years seems to be a reasonable number).”
    If you are getting your health news from NBC, you may not know this, but in almost every study ever done where the low carb group actually ate low carb, the low carb group improved in every parameter measured.
    3. “- Properly designed scientific studies that predict that this diet, if adopted by a majority of the world’s population, will not have a negative effect on the environment”
    Just look at what negative effect on the environment that grain agriculture has.
    4. “- Properly designed scientific studies that predict that this diet, if adopted by a majority of the world’s population, will not have a negative effect on the health and welfare of animals.”
    This is the same as #3.
    I think one of the most important themes that Eades, Taubes and other writers, like Enig and Fallon, show repeatedly is the history of isolated, native populations that are long-lived, healthy, and primarily meat-eaters. There is an isolated Swiss population- one of the longest living populations on the planet- whose diet is composed mostly of butter, cheese, milk, cream, and beef. They don’t require the services of doctors. There is another population in Okinawa that eats enormous amounts of pork, lard, spam, and other tasty animals- and they are neck and neck with the Swiss in terms of health and longevity. Look at the Pima, the Inuit, the Masai of Africa, the Argentinian Gauchos (meat & tea), the American Indians (before govt rations), The French, Austrians, and Greeks… even some isolated Irish. The thing all those native populations have in common is that they don’t eat a high carb Americanized diet. It’s the American Paradox: the Americans eat tons of processed, refined grains yet they’re still alive.
    Looking at the totality of the evidence like association studies, or even the gold standard of clinically controlled, double blind metabolic ward studies will only give you a snapshot of a given moment of time which is nothing but a drop in the bucket of history and human evolution.

  63. I can’t begin to tell you how much I appreciate your critique of The China Study. I have been back and forth between veganism and low carb (mostly paleo) for years trying to decide which one is best for my health. In the meantime, I have gained a lot of knowledge plus 50 lbs.! Your critique has finally tipped the balance toward a protein based diet rather than the McDougall starch based diet I was on. I will admit that the McDougall diet assured me I would never be constipated, but I also gained weight on it. I have seen many forums and symposiums online and read books by Dr. Campbell, Dr. McDougall, Joel Fuhrman and Neal Barnard and they certainly do sound convincing, esp. in the light of all the things I had been brought up to believe about fat and meat. But after learning about the latest study that shows that a low carb diet actually lowers bad cholesterol and reading your critique of the China study, I am back to a protein based low carb diet. Thanks for taking the time to critique the China Study which is the Bible for low fat vegans.

    1. When all the low fat eaters start dropping like flies, people will wise up and start reading at http://www.westonaprice.org
      Only then will they learn the REAL truth about how to eat grains (soaked before consumed) and fermented foods (for the health of the gut) and how to nourish a child from birth forward.
      Until that time, people will truly remain ignorant of the nutritional world.

  64. Brett brought up the old bogey, that excess protein might damage the kidneys. I know you cite evidence that the opposite is true, that protein tends to protect the kidneys, and I think that you are right, but I think I can see where the opposite claim is conditionally true.
    The metabolism of protein depends on many (perhaps all) the other nutrients, and none more so than pyridoxine (B6) in its active form, pyridoxal-5-phosphate. P-5-P converts essential amino acids to inessential ones, removes the amine group (“ammonia”) when surplus amino acids are converted to calories, and processes this to urea which is safely excreted by the kidney (assuming you drink water, another variable).
    It follows that the more protein you eat the greater your requirement for B6, and that eating a high-protein diet while B6 deficient might cause problems. We are talking about a requirement of 2mg (from memory) for a standard diet. However, sub-optimal levels of B6 are not uncommon. The conversion of dietary B6 to P-5-P requires minimal gut and liver function, and co-factors including B2, magnesium and zinc. In uncompensated cirrhosis of the liver, the ability to convert vitamins to coenzymes and to metabolise protein fails, so that protein toxicity occurs.
    From this it can be seen that it is possible to “prove” that extra protein is harmful just by restricting B6 or a number of other factors. Foods that are high in protein (such as nuts) tend to be high in B6, but the isolation of protein which is then added to foods (such as casien and gluten), and the cooking and processing of protein foods tends to reduce the B6 content.
    B6 occurs in whole protein foods because the plant or animal needed it to produce the protein in the first place.
    The amount of B6 needed to metabolise protein is small, of P-5-P even smaller. B6 is the rare vitamin that can have long-term toxicity, it can also compete with folate for absorption, and I tend to favour the multivitamin with the lowest ratio of B6 to B1, B3 and B5.

    1. Shirley Jackson: A low-carb diet (very high fat, medium protein, very low carb) got my LDL to 108, my HDL to 98 (ratio 1.1) and my Tryglycerides to an all-time low of 69. The doctor could hardly believe it when the lipid panel came back.

  65. This is from your post back in 2007 re:GCBC (when it was first coming out)
    @Mike Hesletine
    “If Mr Taubes book were to be taken seriously and lauded through all media services its ramifications would be staggering. If taken seriously it could have devastating consequences for the food industry all the way up the food production chain from the farmer through every step to our mouths. The pharmaceuticals industry could be severely affected as people throw away their statins and blood glucose monitors. The economic impact would play havoc on whole economies of nations.”
    It is happening now. (Not lauded throughout MSM, but taken seriously by more people every year. The Medical Business, the Oil Business, and the Food Companies are together a big part of our economy.)

  66. Dr. Eades, I appreciate your analysis of The China Study. For the last year I’ve been deeply immeshed in the low fat vegan diet which Campbell and others recommend and only recently I have gone back to a more low carb way of eating (South Beach Diet) and added dairy and eggs back into my diet. I have to admit I was bitterly disappointed that The China Study has been exposed to be so selective with the data and observational but it makes me feel more confident in my choice to go back to eating animal products (I still don’t eat meat and fish and probably never will because I just don’t like it). For the record, I don’t think there is anything inherently wrong with taking on a vegan lifestyle and diet – I just don’t believe it’s the be-all end-all of health anymore. If humans are omnivores then some people do well on a diet similar to Protein Power and some on other types of diets. It’s about finding what works for you :).

  67. I don’t understand, Dr. Mike, why you are concerned about having “low cholesterol”? I thought you were a reader / believer of the WAPF conclusions, and Chris Masterjohn, too, about cholesterol being totally necessary for our bodies. Who wants “low” cholesterol? I’m much more concerned with high homocysteine levels.
    Any suggestions for us meat eaters (and all things protein) about how to raise our cholesterol? My DH and I have both been trying for about four years to raise ours above 200 and it seems like an impossible task. We drink raw milk from a reliable source, eat healthy and well (no boxed or canned foods) only pure grass-fed beef, pasture-fed chicken and duck eggs, and still we struggle to jack up the cholesterol. When we have blood draws done, I pretty much ignore the LDL and HDL kerrrrap.

  68. Hi Dr. Eades,
    I made a new blog post about reductionism vs. holism that I thought you would enjoy:
    Reductionism and Holism Go Hand in Hand
    I reference your China Study critique towards the beginning. It ends with an analysis of a rather bizarre method of “dietary pattern analysis” that was recently used to claim that foods rich in B12 promote Alzheimer’s.
    Chris Masterjohn

  69. Dr. Mike, sorry for the off-topic question, but I’m having some trouble with high blood pressure since starting menopause 5 years ago. Today I was turned down at the local blood drive because it was 150/104. Yikes, I know. I usually take Thorne Magnesium Citramate (per your recommendation in your “Magnesium and Inflammation” post in 2005), but haven’t taken it in several weeks.
    My question is on the dosage. The RDI for magnesium, you say, is 360 mg. In your Lifeplan book, you say to look for the RDI on the bottle and see if it shows the combined weight of the magnesium plus the chelating agent. Well, the Thorne product shows it as “Magnesium (as Magnesium Citrate-Malate)” and lists it as 150 mg per capsule. So how much pure magnesium am I really getting with this? The bottle also says that 150 mg is 38% DV (daily value, not RDI). It also says that DV has not been established.
    Now I’m really confused.
    Should I be taking 3 a day? 4 a day? Things get pretty “loose” even with 3 a day, but it seems like I need that much.
    Might a different formula be better for me?
    I appreciate your taking the time to respond, but I also know that you’re a busy guy, so I won’t be surprised if you can’t get to this. Thanks just in case.

  70. Me again. I usually take potassium, too, usually 4 capsules a day, which comes to 396 mg. I know magnesium and potassium go hand in hand.
    Also, do you think supplementing with calcium (specifically Calcium Citrate) is a good idea, and if so, how much?
    I’m 55 and my recent bone scan came back +1.4, which means I’m very dense. Hubby has been saying that for years!

  71. Hi Doctor
    In the 6WC you mention Apheresis as the better choice for blood donation, how about reducing Iron overload is it also better than the regular blood donation?

  72. Dr. Eades,
    First off, I’m a huge fan of your work and think you bring a refreshing viewpoint to the fields of nutrition and weight loss.
    I’m an exercise physiologist with a specialization in nutrition by training who work primarily in the weight loss setting now, so I thought I’d add my 2 cents to the lengthy discussion you and a reader Brett had a while back.
    It seems that Brett had a number of questions and criticisms pointed towards doctors such as yourself and Dr. Atkins who prescribe higher protein intake as a means to lose weight. In particular he challenged you to present:
    – Properly designed and controlled scientific studies that show there are no long-term negative health effects of this diet
    – Properly designed and controlled scientific studies that show this diet significantly improves weight loss over a long period of time (five years seems to be a reasonable number).
    – Properly designed scientific studies that predict that this diet, if adopted by a majority of the world’s population, will not have a negative effect on the environment
    – Properly designed scientific studies that predict that this diet, if adopted by a majority of the world’s population, will not have a negative effect on the health and welfare of animals.
    I’d counter that this last point is an impossibility, as the wide variety of genetic variation among the human species makes trying to establish a “one-size-fits-all” diet prescription a fool’s errand.
    Moreover, anyone who done nutrition research using human subjects will understand how incredibly difficult running long-term interventions tend to be (i.e. a 5 year time frame), as humans as notoriously non-compliant over long-periods of time. Therefore, will I agree with him that it would be great to see such a study, the money and labour-intensiveness of such a project is far beyond what is reasonable to expect.
    In terms of my opinion of the findings of the China study on the whole, even though correlation is not causation, I’m willing to accept that many of the improved health outcomes found in the China study do exist… if only because the thousands of years of evolution of native Chinese to those particular foodstuffs leave them well adapted to thrive on such a largely plant-based diet.
    In the same vein, the traditional Inuit diet in Canada is one that centers heavily on fish, seal and other meats, with very little vegetable intake of any kind, yet they too have a very low incidence of chronic disease.
    Does this mean we can conduct a study on the Inuit, then conclude all of mankind should eat nothing but meat? I should say not.
    Instead of staunchly arguing for a “best” diet, why not accept that our nutrition recommendations need to pay greater attention to the metabolic and endocrine responses each individuals has to a particular foodstuff?
    I recently wrote a couple of articles that may be of interest to Brett (and those of similar beliefs) that look at efficacy of different types of diets over a 1-2 year time period. The 2nd article in particular covers how we can use different tests (i.e. insulin sensitivity, certain DNA markers) to predict the likelihood of improved weight loss response.
    Just as you highlighted in the paper that was published in Annals of Internal Medicine several weeks ago, tremendous weight loss is possible through a variety of diets. I’d like to add that when we match an individuals genotype to the right diet, we tend to get far better results.
    This is what I’ve found in the literature, as well as in my own day to day practice.
    Again, my position is one of an individual who works with clients needing improvements in body composition, so I can’t speak to overall reductions in total chronic disease risk. But as anyone with a science background will attest, decreasing body fat is one of the surest ways of improving overall health.

  73. Here’s an interesting item fro the NY Times (who I don’t often regard as an authority on diet):
    For people, several historical cases may suggest a nutritional link. Bones of 16th-century American Indians in Florida and Georgia showed significant increases in osteoarthritis after Spanish missionaries arrived and tribes adopted farming, increasing their workload but also shifting their diet from fish and wild plants to corn, which “lacks a couple of essential amino acids and is iron deficient,” said Clark Larsen, an Ohio State University anthropologist collaborating with Dr. Peterson. Many children and young adults were smaller and died earlier, Dr. Larsen said, and similar patterns occurred when an earlier American Indian population in the Midwest began farming maize.
    I’m sure they’ll be able to ignore the evidence and still support the FDAs pyramid. Ya think?

  74. “What this all tells me is how wonderfully adaptive the human species is where diet is concerned. It’s no wonder we took over the earth.”
    This made me 🙂 .

  75. Another BOOK. If you enjoyed “Lucy”, you might like:
    Nick Lane’s “Life Ascending: The Ten Great Inventions of Evolution” is a must read. I can’t put it down. I’ll confess that I couldn’t quite get through his book “Oxygen: The Molecule that Made the World”, but you win some you lose some with me! Evolution is da bom.

  76. Hi Dr. Mike,
    Hope you can get back to blogging soon as we all miss you! You have to comment on Dr. Van de Graaff’s piece on statins on KevinMD. It is so over that top and dismissive of criticism that I was left speechless (which doesn’t happen very often). Soooo, hope you and MD are well and enjoying life!

  77. It was cool to see the Sous Vide Supreme featured on Master Chef on Fox last night!
    Any publicity is good publicity, right? And at least 3 great chefs are now aware of the device.
    my only question is, how did that guy manage to make a piece of beef in 60 minutes with the sous vide supreme – I thought the point of sous vide was hours and hours of cooking at low temps.

  78. Dr. Eades, do you have any comment on this just published study in Annuals of Internal Medicine: “Low-Carbohydrate Diets and All-Cause and Cause-Specific Mortality
    Two Cohort Studies” ( http://www.annals.org/content/153/5/289.abstract) :
    Objective: To examine the association of low-carbohydrate diets with mortality during 26 years of follow-up in women and 20 years in men.
    Design: Prospective cohort study of women and men who were followed from 1980 (women) or 1986 (men) until 2006. Low-carbohydrate diets, either animal-based (emphasizing animal sources of fat and protein) or vegetable-based (emphasizing vegetable sources of fat and protein), were computed from several validated food-frequency questionnaires assessed during follow-up.
    Setting: Nurses’ Health Study and Health Professionals’ Follow-up Study.
    Participants: 85 168 women (aged 34 to 59 years at baseline) and 44 548 men (aged 40 to 75 years at baseline) without heart disease, cancer, or diabetes.
    Measurements: Investigators documented 12 555 deaths (2458 cardiovascular-related and 5780 cancer-related) in women and 8678 deaths (2746 cardiovascular-related and 2960 cancer-related) in men.
    Results: The overall low-carbohydrate score was associated with a modest increase in overall mortality in a pooled analysis (hazard ratio [HR] comparing extreme deciles, 1.12 [95% CI, 1.01 to 1.24]; P for trend = 0.136). The animal low-carbohydrate score was associated with higher all-cause mortality (pooled HR comparing extreme deciles, 1.23 [CI, 1.11 to 1.37]; P for trend = 0.051), cardiovascular mortality (corresponding HR, 1.14 [CI, 1.01 to 1.29]; P for trend = 0.029), and cancer mortality (corresponding HR, 1.28 [CI, 1.02 to 1.60]; P for trend = 0.089). In contrast, a higher vegetable low-carbohydrate score was associated with lower all-cause mortality (HR, 0.80 [CI, 0.75 to 0.85]; P for trend ≤ 0.001) and cardiovascular mortality (HR, 0.77 [CI, 0.68 to 0.87]; P for trend < 0.001).
    Interestingly on the front page of the journal's website there is a poll question, "When advising patients about weight loss, which of the following types of diets do you most often recommend? " and the results with 63 votes are:
    low carbohydrate diet 46.03% (29 votes)
    low fat diet 28.57% (18 votes)
    other diet type 11.11% (7 votes)
    no specific diet type 14.29% (9 votes)

  79. worthy of yr skillful combat ?
    Dr. Dean Ornish.Medical Editor, The Huffington Post, Founder and President of Preventive Medicine Research Institute
    Posted: September 7, 2010 07:00 AM BIO Become a Fan Get Email Alerts Bloggers’ Index .
    Atkins Diet Increases All-Cause Mortality
    What’s Your Reaction:diggfacebook Twitter
    del.ico.us Inspiring
    Read More: Atkins Diet , Atkins Diet Death , Atkins Diet Mortality , Atkins Diet Plan , Dean Ornish , Health , Low Carb Diet , Living News
    views163Get Living Alerts
    Email Comments 163 A major study was just published in the Annals of Internal Medicine from Harvard. In approximately 85,000 women who were followed for 26 years and 45,000 men who were followed for 20 years, researchers found that all-cause mortality rates were increased in both men and women who were eating a low-carbohydrate Atkins diet based on animal protein.
    However, all-cause mortality rates as well as cardiovascular mortality rates were decreased in those eating a plant-based diet low in animal protein and low in refined carbohydrates. Although this plant-based diet was called an “Eco-Atkins” diet, it’s essentially the same diet that I have been recommending and studying for more than 30 years.
    In many debates with Dr. Atkins before he died, I always made the point that it’s important to look at actual measures of disease, including mortality, not just risk factors such as HDL cholesterol. This is the first study that examined mortality rates in those consuming an Atkins diet, and it confirms what I’ve been saying all along: an Atkins diet is not healthful and may shorten your lifespan.
    Dr. Atkins and I agreed that the American diet is too high in refined carbohydrates such as sugar, white flour and concentrated sweeteners) which promote a variety of chronic diseases. That’s why people often lose weight on an Atkins diet when they restrict their intake of refined carbohydrates.
    However, the answer is not to replace refined carbohydrates with animal protein such as beef, pork rinds, bacon and sausage, which Dr. Atkins claimed were good for your heart. I’d like to be able to say that they’re good for your heart, but they are not. It’s much more healthful to replace refined carbohydrates (“bad carbs”) with healthy carbs instead.
    It’s not low-fat vs. low-carb. An optimal diet is high in healthy carbs such as fruits and vegetables and whole grains (including whole wheat, brown rice), legumes, soy products, nonfat dairy and egg whites in their natural forms and some good fats such as the omega 3 fatty acids found in fish oil and salmon. It’s low in unhealthy carbs such as sugar, white flour, white rice, white flour pasta and low in saturated fats and animal protein.
    The message that many studies — including one in the Annals last month — have been giving the public and health professionals is that the Atkins diet is no worse for your heart than a plant-based diet, but all these studies examined only risk factors such as HDL, not measures of disease or mortality. That’s why this new study is so important. (The Annals recently published my letter to the editor that expressed these concerns, which I appreciate.)
    A recent study reported in The New England Journal of Medicine found that an Atkins-type diet “promotes atherosclerosis (heart disease) through mechanisms that do not modify the classic cardiovascular risk factors” such as HDL. Other studies also showed this.
    Your body makes HDL to remove excessive cholesterol from your body. Eating a stick of butter will raise HDL, but butter is not good for your heart. Pfizer discontinued a study of its drug, torcetrapib, which raised HDL but actually increased risk of heart attacks.
    Conversely, a whole foods plant-based diet that’s also low in refined carbohydrates may reverse coronary heart disease and beneficially affect the progression of prostate cancer and even improve gene expression despite reductions in HDL.
    Finally, what’s good for you is also good for our planet. Livestock consumption causes more global warming than all forms of transportation combined. It takes 10 times more energy to produce animal-based protein than plant-based protein.
    It’s not all or nothing. You have a spectrum of choices. What matters most is your overall way of eating and living. If you indulge yourself one day, eat healthier the next. To the degree that you move in a whole foods, plant-based direction, the better you’re likely to feel and the healthier you’re likely to become.
    Dean Ornish, M.D.
    Medical Editor, The Huffington Post
    Founder and President, Preventive Medicine Research Institute
    Clinical Professor of Medicine, University of California, San Francisco

  80. The question is WHY would someone go to such lengths and risk loss of credibility (maybe he never consider that)? Yeah, $$$ Book sales? Grants?
    Reminds me of the popular Von Daniken’s book decades ago, “Chariots of the Gods,” that was presented in such a way as to sound supported by science. Von Daniken later admitted that the book was entertainment-pseudoscience writing popular in Europe at the time. Although the scientist Carl Sagan did not rule out the possibility of visitation by extraterrestrials, he insisted that “extraordinary claims require extraordinary evidence”, which Daniken failed to provide.
    So, too, Cambell’s extraordinary claims require extraordinary evidence.

  81. I’m amazed that you say “Bob Atkins and I have had our differences, but were he still alive, I would vastly prefer to put my own care in his hands than I would those of Dr. Campbell, who has never treated a patient in his life.”
    Robert Atkins died aged 72 of a heart attack, congestive heart failure, and hypertension. It is reported he was “just under” 6 feet tall and weighed 195 Lb when admitted to hospital. His BMI was therefore 26.4, considered as “Overweight.” Not exactly a ringing endorsement for his diet, don’t you think?
    Before I started on a Vegan/Macrobiotic diet I was 192 Lb and am also 6 feet tall. After a couple of years (now aged 64) I am a stable 148 Lb and eat as much as I like. I also feel much better anfd I no longer get the frequent colds and throat infections that I used to have.
    I have read “The China Study” and although I’m not qualified to critique the work, I was impressed by the study (I have a B.Sc in Physics). It was perfectly obvious to me that Campbell was talking about rat studies in dietary protein and enzyme activity, contrary to your statement that it was “probably implanted in the minds of many readers that he’s talking about human studies.” OK, so it’s only your opinion (based on what?).
    I understand the American Medical Association dismissed his diet as nutritional folly, saying it was “potentially dangerous” and “biochemically incorrect”, Not that I’m a fan of the AMA either.
    I do not pretend to be an expert about diet and nutrition, and given the lack of scientific evidence, have to make my own (hopefully informed) decisions on the topic. However, I did not find your analysis very objective.

    1. Dr. Atkins died of a head injury from slipping on an icy sidewalk. His widow released enough of his medical records to make that plain. Anyone can suffer cardiac arrest if they’re brain-damaged enough. He was. He also suffered severe fluid retention since his body was not able to regulate his fluid balance adequately after his injury.
      I know of someone who died of breast cancer on a macrobiotic diet. Cancer loves sugar. Even sugar made from starch.

  82. I wonder if the results of Campbell’s rat studies with casein were from feeding them the A1 casein variant, which results in a peptide called BCM-7. This peptide targets the opioid receptors and is highly correlated with higher rates of heart attacks, strokes, diabetes, and cancers, with numerous studies showing a direct effect. If the rats had been fed A2 casein, they might have been fine.
    There is a good book about this from Woodford, Devil in the Milk, highly recommended.

    1. Hi Tim,
      A few days ago I published a comprehensive review of Campbell’s casein-cancer research. This post shows that the effects were actually a general effect of protein rather than a specific effect of casein or animal protein, but that Campbell egregiously misrepresented these findings by leaving out the fact that although the high-protein diets promoted pre-cancerous lesions that had already been formed, they increased the acute toxicity of aflatoxin and other chemicals, increased the risk of death from chemical overdose, decreased tissue repair, led to fatty liver in certain strains of rats, and actually increased the *formation * of pre-cancerous lesions. You can find my post here:

  83. Can an epidemilogical study prove a negative? Partly because of your frequent reminders, I now know it cannot prove a positive. But if, for example, 90% of a population does not get disease X while getting 60% of its calories from say coconut oil, does this prove that, at least for this population, coconut oil does not cause disease X?

  84. Scanned the posts and felt I had to reply to the ones that indicated no supporters of Campbell’s theories. Sorry to say I am 80 years old and my brain can no longer follow all of the arguments and will admit to not now being a great critical reader.
    What I detect and which was admitted was a bias towards a contrary view without indicating that there have been studies by eminent physicians supporting a diet similar to Campbells. Namely by Dr. Caldwell Esselstyne, who has treated thousands of patients and has done his own study in “Preventing and Reversing Heart Disease” and points out the difficulty in getting funding for large scale causation studies, since these are mostly funded by biased Dairy, Meat and Drug Companies. Also another ‘vegan’ M.D., Dr. John Macdougal has also treated and helped hundreds or thousands of patients successfully. Other supporters of this diet are indicated by ‘The Blue Zones’ and also M.D.’s Dean Ornish and Dr. Oz. Please excuse poor structure as I am on chemo therapy.

  85. Please comment on this one…
    Low-Carbohydrate Diets and All-Cause and Cause-Specific Mortality: Two Cohort Studies Teresa T. Fung et al. Annals of Internal Medicine September 7, 2010, vol. 153 no. 5 289-298
    As a diabetic I following a very low carb diet protein and fat based (w/o a choice) and lost weight and mainting healthy- normal bg levels most of the time.
    This sort of study means many medical care professionals with yet again discourage the Low Carb diet as unhealthy. And the media will raise red flags and hype.

  86. “correlations don’t prove causation.”
    …then I guess we can all start smoking again, as it’s never been PROVEN that cigarette smoking causes cancer.

  87. Regardless of the validity or non-validity of the books and studies in question, or useful debate raised, the overt and covert nastiness displayed in many of the posts here about those who eschew meat for any reason is unbelievably offputting (“unfortunately the high carb people tend to breed before dying?” wow–tell us how you REALLY feel!). It really undercuts, for me, a lot of the value that could be gotten from specific information here had it been presented in a truly neutral fashion. Can you not acknowledge a smug and self-satisfied tone in not only the author’s post but more so, the responses? The dismissive tone, not only dismissing Campbell but any and all vegetarian or meat-eschewing individuals or proponents. Nearly everyone posting is all too quick to basically say “Thank you! You have affirmed that it is reasonable to dismiss not only this, but ALL data EVER suggesting a veg diet is a valid choice ethically and healthwise. Just what we all always wanted! License to enjoy unlimited meat and be RIGHT!” There is unquestionably an ATTITUDE prevailing here.
    A balanced vegetarian or vegan diet of whole and organic foods that one wishes to choose for ethical reasons may not have proven what Campbell claims it did, but to thus dismiss such a diet *on all other grounds because of it*, in one simplistic fell swoop, is a leap that your readers are all too happy to make and you encourage this, without acknowledging that to do so is to do something similar to what you vilify Cambell for doing. It’s not scientific to say (a) Campbell was obfuscating, therefore (b) all information ever put forth supporting the viability of a plant-based diet is fallacious and worthless, and proves the subjective experience of all meat-loving posters here.
    I have never been militant about my diet or choices, I am knowledgeable and moderate, I and others I know do thrive on a veg diet just as it is possible to thrive on a moderate and balanced meat-including diet. I find the “glee” openly admitted to here, the unbridled JOY in someone having cut down one particular book or author and therefore “freeing” everyone to happily enjoy meat and snidely sneer at vegetarians, to be extremely offensive. So is the endless berating about Campbell’s selectivity while creating and encouraging a collection of posts that is just as selective. One could not call this an evenhanded forum. This entire forum reads like a big club of crowing, vindicated meat lovers. The glee in the bad health of some people on plant-based diets is downright ugly.
    For every unhealthy plant-based diet person someone posting here knows, we could also cite examples of terribly unhealthy meat eaters. To not point this out is pretty obfuscating too.

    1. I don’t know of any terribly unhealthy people who eat only meat. Every time a veg*n brings up some “unhealthy meat-eater,” inevitably it is a “meat-eater” who eats a grain-based diet. Grains, last I checked, come from plants.
      I grow tired of sharing my story of probable subclinical vitamin A deficiency. Let’s just say I’m beyond angry that people are allowed to continue to believe that beta carotene and vitamin A are the same thing, and that I’m not the least surprised we’re facing an infertility epidemic in this country which, as far as I’m concerned, has far less to do with women delaying childbearing til their thirties than it has to do with women being fat- and animal-nutrient-starved for decades, if not all their lives, to begin with.
      There is no ethical reason to be veg*n. You have to kill animals in order to raise food plants. Have to. There is no way around it. If slaughterhouse conditions bother you, become a more savvy consumer of animal foods rather than eschew them entirely.

    2. I think you’re reading a lot more into this post and this thread than is there. People are dicks, this is the internet, nobody cares.
      Dr. Eades’s website and blog are certainly not evenhanded and “fair”, do not claim to be, and probably never will claim to be. If you expect that, this is the wrong place for it. He vents here, he posts things that interest him here. None of it that I’ve read is meant to be an olive branch to people with your viewpoints.
      Since you seem to be so sensitive, I will prepare a bowl of raw meat to eat with my bare hands tonight. Maybe, I’ll even just sick my face in it and smear the dead flesh blood everywhere while howling at the moon and running around naked. ‘Cuz meat eaters do that, amirite?

  88. Ouch!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!
    Thanks Dr.Eades, and to think the China Study was a cornerstone of our becoming vegansssss…….
    Thank you Dr.Eades, Sally Fallon, Jimmy Moore, Lorain Cordain and Robb Wolf for saving my life!
    I am now on my road to get health which you can follow on my blog http://guythehealthypaleoguy.wordpress.com/
    And a Paleo + exercise challenge for October 2010, Please encourage and follow my progress on facebook!
    Thanks Dr.Eades!!!!!!! Guy

  89. (Sorry for the re-post, the second link was bad)
    Thanks Dr.Eades, and to think the China Study was a cornerstone of our becoming vegansssss…….
    Thank you Dr.Eades, Sally Fallon, Jimmy Moore, Lorain Cordain and Robb Wolf for saving my life!
    I am now on my road to get health which you can follow on my blog http://guythehealthypaleoguy.wordpress.com/
    And a Paleo + exercise challenge for October 2010, Please encourage and follow my progress on facebook!
    Thanks Dr.Eades!!!!!!! Guy

  90. ARGH!!! Stupid, stupid Bill Clinton!!
    In order to lose weight for his daughter Chelsea’s wedding, he gave up all dairy, eggs, and almost all meat. He has since lost 24 pounds and says he feels great.
    Among other things, he said the famous book, The China Study influenced his decision and referenced studies of people who adopt a plant-based diet in order to cleanse their body of the cholesterol and calcium deposits that clog their arteries.
    {end quote}

  91. I’d really like to see what “Brett” has to say about this: http://www.westonaprice.org/book-reviews/thumbs-down/421-eat-to-live.html
    I’m assuming he wouldn’t be interested in reading it, at least not with an open mind. He probably, then, wouldn’t want to read this either: http://westonaprice.org/take-a-guided-tour/vegetarians.html
    Funny how he doesn’t think that Barrett is a shill.
    I made a couple of comments here earlier today, but nothing has been posted.

  92. I have tried and tried to post to this site. I have tried writing directly to Dr. Eades, all to no avail. I can’t get to any of the newest posts unless they come to my inbox. It’s like this never updates itself. What is going on, anyhow??

    1. For whatever reason, all your comments ended up in the spam file. I rescued them and am in the process of posting them.

  93. President Eisenhower had low cholesterol too. And died of a heart attack.
    I’d need to see a lot more from Dr. Campbell than just a vague statement about his weight and cholesterol levels before I’d believe he’s healthy and not just not-unhealthy. There’s a difference.
    I just don’t have it in me to be overly generous to a, as he put it, snake-oil salesman.

  94. Dr. Eades,
    I was enjoying much of your material until I read this blog. In it I find that it is you who has written a glaring masterpiece of obfuscation.
    The China Study is a massive and sophisticated study, producing over 8000 statistically significant associations between various dietary factors and disease. It is the largest and most comprehensive study ever undertaken in the history of medicine, to show the correlation between diet and the risk of developing disease. There is a reason that the NewYork Times refered to the China Study as the “Gran Prix of Epidemiology.” , involving 13,000 subjects from 65 counties of 24 of the 27 provinces of China, over the expanse of 20 years. Which you so quickly pass off based on your “several and singular years of experience as a physician” and the data that you have collected on a variety of lipid panels from your patients. Quite a narrow comparison of data in relation, one would have to admit, but not to say that your findings aren’t relevant. I believe they are a piece to an otherwise very large puzzle. But at the same time not relevant or interring with the China Study findings if the relation is understood correctly.
    I find it curious that your own experience and findings you hold so strongly to but critisize a respected and renown scientist, Dr. Colin Campbell and his book and smugly assert that it is as a masterpiece of obfuscation. By passing off the study as you have, you are not only being rude and disrespectful but are using your influence to negatively affect your readers. I believe your responsibility is much larger than that.
    What I believe, based on your blog, is that you have focused your attention on trivial wording and phrases, going off in a tangent that is completely off course, in fact failing to look at the book and the study as a whole. If you had, i believe you would have come up with a very different view. I believe that your nit-picking is based not so much from an intellectual stance but from bias, which you openly admit to as well as the underlying basis of your beliefs and values, which in fact may not have entirely blinded you from the truth but caused you to avoid it and refuse it.
    If you are looking at one fence post.. you cannot tell what direction the fence is going in … only after ‘lining up the fence posts’ can you make out the direction of the fence, whether it is going South or NorthWest. What you have done is not only focused on one fence post but you have scrutiinized it’s very knot. Essentially so has Ms. Minger.
    Here ia a gross example of your masterpiece of obfuscation:
    I was ready to wash my hands of the whole affair when I came across another statement Dr. Campbell made in his response to Ms. Minger’s critique. Writing of her, he said:
    One further flaw…is her assumption that it was the China project itself, almost standing alone, that determined my conclusions for the book (it was only one chapter!). She, and others like her, ignore much of the rest of the book.
    Only one chapter? As I mentioned above, I always figured The China Study was simply Dr. Campbell’s tale of the China study and the conclusions he had drawn from it. Now he says that only one chapter is about the China study, leaving me to conclude that the rest must be about something else. I found the book, which I hadn’t yet taken from the pack it came in from Amazon, opened it and started reading.
    This is a classic case of twisting words, taking things out of context.
    I have read his book and much more than one chapter of that book discusses the China study. (If you had read it you would know this). So what makes you an authority on his book when you haven’t even read it!
    You also go further in taking what Dr. Campbell wrote in response to Ms Minger’s critique out of context and then went on in a mocking manner. Essentially, you used what you could, creating a masterpiece of obfuscation, (although not so much as one can see through it) to support what you actually admitted to as a bias.
    I too am personally involved in helping people to lose weight and regain their health. I agree that there is much to be said about the value of protein in our diet. As a medical practiioner and seeker for truth you have come a long way in understanding the problem of obesity which is why I have enjoyed reading your blogs. Having said that, why stop there?
    I don’t beieve that Dr. Campbell has an issue with protein or the value it plays in diet. What he points out however is inarguable in reference to the comparison of animal-based foods to plant-based foods. In his book he states, “There are virutally no nutrients in animal-based foods that are not better provided by plants.” The chart he provides on page 230 of his book makes that very clear. Do the research yourself and test the findings on the chart…it will not lie.
    Here are a few examples: Per 500 calories of energy in comparing animal-based foods to plant based.
    Protein (g) in equal parts of tomatos, spinach, lima beans, peas, potatoes = 33
    Protein (g) in equal parts of beef, pork, chicken, whole milk = 34g
    Dietary Fiber(g) : 31 in plant based and zero in animal based
    Vitamin C(mg): 293 in plant based and 4 in animal based
    Folate (mcg): 1168 in plant based and 19 in animal based
    Calcium (mg): 545 in plant based and 252 in animal based
    The list goes on….. So my point is, sure protein is a valuable player in helping people lose weight and acheiving good heatlh… so what is so bad about making sure we get that “Protein Power” from plant based foods as opposed to animal based foods when we are getting a lot more bang for our buck!
    I also want to reccommend to your reader’s to read the entire response to Dr. Campbell on Tynan’s blog and have provided the following link.. http://tyn
    an.net/chinastudyresponse Initially Tynan too was affected by the comments of Denise Minger and he wrote to Dr. Campbell for a response, an intelligent decision to go to the writer of the book to explain himself. The blog includes Dr. Campbells response entirely. Dr. Campbell responds to the critique from a very thoughtful and logical place. I believe it is impossible to read his response without seeing the clearness of it. In short Ms. Minger is misguided in her critisizm. It never ceases to amaze me how people are so eager to shoot off their mouths when in fact they don’t have all the facts or they choose to skim over them to make a case for what they want to believe and are unwilling to accept truth no matter how plain it is before them.
    In other words, If we really desire truth we will accept it… generally it comes down to simply a matter of personal pride and prejudice as to why we don’t.
    All the best,
    Suzanne A.

    1. I’ll have to say that my post must have been obfuscating to you because it’s obvious that you didn’t understand a bit of it.

      1. @ Suzanne A,
        the message I got from Protein Power was to eat more whole animal products, and eat more green leafy vegetables, nuts and seeds, while eating moderate legumes, berries & coloured fruit, no grains or sugar or processed vegetable oils (vege oils other than olive oil). It’s not a competition between animal foods and heathful veges, it’s about, in large part, replacing the unhealthy vegetable-derived foods in our diet that never existed 200 years ago when cancer, diabetes, autoimmune-disease etc were rare.
        Regarding the vitamin C content, people with insulin resistance have trouble using vitamin C, because it enters the cells via glucose receptors, one reason why IR is a factor in cancer.
        Regarding mineral values of vegetables, carbohydrates tend to deplete minerals used in their metabolism such as magnesium and chromium, and whole grains are rich in phytates which block absorption of calcium, zinc and bind to carotenes and retinol. Also, gluten sensitivity, a rising plague associated with and linked to all the modern diseases, interferes significantly with the absorption of a wide range of minerals and vitamins. There is almost nothing like this in animal foods (some raw fishes block thiamine, and large amounts of raw egg white can inhibit biotin, but the anti-nutrient effects of gluten and phytates are far more general).

  95. I have yet to see where plant based food nutrition equals per weight equals the same as animal based food. Not to forget the essential fats one gets from animal foods.
    And that those particular fats have a lot more to do with providing optimum health than the wee amounts available in plants.
    Surely all of it has to do with what carbs do in the body than plants providing equal nutrition as animals. For one, why else would a person have to eat dozens of oranges to just obtain the RDA of vitamin C?
    And as far as this China study goes, does it negate the ‘Vilhjalmur Stefansson experiment and studies in 1928? Or this man’s personal experiences living amongst the eskimo for extended periods on just meat and fat diet?
    Would this tend to corroborate what Gary Taubes was writing about in ‘Good Calories; Bad Calories?
    Think I’ll go eat a cut of sour cream, seems to calm me more than dumping sugar into my body.

  96. Dr Eades, this blew my mind when I found it today;
    Of course it’s the opposite of what everyone with liver disease is told; endotoxins are important in viral hepatitis as well as alcoholic liver disease, as of course are lipid peroxides.
    Dietary Saturated Fatty Acids Reverse Inflammatory and Fibrotic Changes in Rat Liver Despite Continued Ethanol Administration
    We investigated the potential of dietary saturated fatty acids to reverse alcoholic liver injury despite continued administration of alcohol. Five groups (six rats/group) of male Wistar rats were studied. Rats in groups 1 and 2 were fed a fish oil-ethanol diet for 8 and 6 weeks, respectively. Rats in groups 3 and 4 were fed fish oil and ethanol for 6 weeks before being switched to isocaloric diets containing ethanol with palm oil (group 3) or medium-chain triglycerides (MCTs, group 4) for 2 weeks. Rats in group 5 were fed fish oil and dextrose for 8 weeks. Liver samples were analyzed for histopathology, lipid peroxidation, nuclear factor-κB (NF-κB) activation, and mRNAs for cyclooxygenase-2 (Cox-2) and tumor necrosis factor-α (TNF-α). Endotoxin in plasma was determined. The most severe inflammation and fibrosis were detected in groups 1 and 2, as were the highest levels of endotoxin, lipid peroxidation, activation of NF-κB, and mRNAs for Cox-2 and TNF-α. After the rats were switched to palm oil or MCT, there was marked histological improvement with decreased levels of endotoxin and lipid peroxidation, absence of NF-κB activation, and reduced expression of TNF-α and Cox-2. A diet enriched in saturated fatty acids effectively reverses alcohol-induced necrosis, inflammation, and fibrosis despite continued alcohol consumption. The therapeutic effects of saturated fatty acids may be explained, at least in part, by reduced endotoxemia and lipid peroxidation, which in turn result in decreased activation of NF-κB and reduced levels of TNF-α and Cox-2.

  97. http://www3.interscience.wiley.com/journal/106595453/articletext?DOI=10.1002%2Fhep.510280401
    a link to Dietary Fats and Alcoholic Liver Disease, by Esteban Mezey
    This is the review of the available evidence from animal trials and a few population studies (the other French Paradox).
    Beef tallow seems to give the best protection, perhaps because it is lowest in PUFAs and contains traces of CLA, which is strongly anti-fibrotic.
    Cis-9, trans-11 conjugated linoleic acid (9c, 11t CLA) is a potential anticarcinogen that is found in higher concentrations in beef lipids. However, the effect of CLA on lipid peroxidation, which is closely related to carcinogenesis, is controversial. In this study, we determined the levels of 9c, 11t CLA contents and thiobarbituric acid reactive substances (TBARS) in the tissues of rats fed beef lipid. Sprague-Dawley rats (male, 8 weeks old) were fed experimental diets containing 20% lyophilized beef, and 12% beef tallow or vegetable oils, for 56 days. With the exception of the brain, the tissues from the rats fed the experimental diets accumulated 9c, 11t CLA, depending on the levels of CLA in the diets. The beef tallow group showed significantly higher 9c, 11t CLA contents in all tissues examined than the other diet groups. The intake of beef lipid did not affect the TBARS levels in the rat tissues. The hepatic lipid content from the beef tallow group was lower than that from the group fed vegetable oils. These results suggest that beef is a good source of 9c, 11t CLA, and that the intake of an appropriate level of beef lipid is not hazardous to health.
    from http://onlinelibrary.wiley.com/doi/10.1046/j.1344-3941.2002.00073.x/abstract

  98. In order to evaluate the protective effect of CLA on carbon tetrachloride (CCl4)-induced hepatic fibrosis in vivo, animals were treated with 10% CCl4 to induce hepatic fibrosis during all experimental periods. Rats were divided into two treatment groups: (1) control diet with tap water ad libitum (n =15) and (2) 1% CLA diet with tap water ad libitum (n =15). In the CLA-supplemented rat livers, a-smooth muscle actin-positive cells were significantly reduced around the portal vein. In addition, collagen fibers were not detected in the CLA-treated group. These results suggest that 9c,11t-CLA influences cytotoxic effect on HSC in an MEK-dependent manner and preserving liver from fibrosis.

  99. I went out and got a copy of the book a few months ago and I honestly don’t understand why all the controversy. As you correctly pointed out, Campbell writes in the book that his interpretation of the China Study data does not constitute absolute scientific proof of anything so why all the fuss? Even someone with a second grade reading comprehension level could have easily pick this up, as I did.
    You are also correct that there’s a bazillion of these pro-meat and paleo diet bloggers who are promoting the Denise Minger “debunking” as some kind of tablet handed down to us from God to Moses, when most of them have not only not read her response too carefully, but they also have never read the China Study in the first place, so how would they know if what she is saying is right or wrong? In my opinion it all seems totally disingenuous, with the WPF/Minger supporters in some frantic effort to get this message viral as if it contains some type of urgent information that we all need to know. Just as idiotic as it may seem for vegans to take the China Study as some absolute truth, there are just as many people willing to accept the criticism of it without doing any critical thinking themselves because they want to undermine Campbell and his message.
    Meanwhile the paleo people are out attacking the vegans for being zealots when they have their own form of zealotry and bias they just don’t want to admit to. It’s all pretty ridiculous 😉
    I personally feel that Campbell is a lot closer to the truth than say, Dr. Atkins ever was, but on this point I will respectfully disagree with you and bow out because I am not a trained professional myself.
    I don’t think anyone has the last and final word on nutrition (including yourself) which seems to be a constantly evolving field.
    Thanks for listening.

  100. @Amy,
    Agreed that many are over-emphasizing Denise Minger’s results, which really just show that the China Study data doesn’t support Campbell’s interpretation with any statistical weight. Indeed, it doesn’t provide much support to any interpretation, due to the epidemiological nature of the data, and further weak study design, even for such an observational study.
    No one may have the final work in nutrition, but we should at least distinguish between those whose conclusions are based in scientific evidence, and those just living in the land of confirmation bias.

  101. Thanks for your interesting and logical critique to the China Study. What are your thoughts on the “blood type diets?” I would be very interested in your critique of the research and claims behind these diets.
    Much appreciation,

    1. I haven’t spent a lot of time myself delving into the blood type diet, but scientists whom I trust have and tell me there is really nothing to it. Most evidence points to various infectious agents driving the differentiation of the various blood types, not diet. In other words, various societies developed specific blood types because people with those blood types were less prone to get infections.

  102. Dave-
    It may be a personal bias of mine but I actually prefer to take my nutritional advice from people with real medical degrees. I don’t really think Denise has proved anything as far as I can tell. Do people think she proved that wheat causes cancer? Or that meat is good for you? What was she trying to prove, that she thinks Dr. Campbell is full of crap? She definitely seems to have proved she can get people to pay attention to her and get high rankings in search engines.
    Others have pointed out that she has made some mistakes in her own analysis which leaves me wondering if she is just as confused, if not more so, than she claims Campbell is. Was she using the right data? Did she really not read the book herself? As someone who is neither a vegan or a die hard meat eater I am just watching the drama pass with some mild amusement. it’s like watching a bunch of people argue about nothing. Maybe they should enter the field of P.R. and just stop wasting our time.

    1. Amy, you’re a pea brain. One thing Denise has proven and that beyond doubt is that Campbell is either incompetent either dishonest. As for your different strawmen, had you really read Denise’s posts, you would know that she never claimed that her analysis of the data showed that meat was good or that wheat was bad. What she showed and repeatedly sayd, was that the highest correlation with bad health markers was with wheat and that the correlations of these bad health markers with meat are inexistant or even worse (for you vegans) negative.
      As for the mistakes in her analsis I suppose you mean that she used univariate correlations in her first analysis as Campbell pointed out, but this shows only the dishonesty and ourtright hypocrisy of him, because all his claims are drawn from univariate correleations and contrary to Denise he infers causality relations from his correlations a thing only a fraudster would do.
      May Dr.Eades excuse me for my direct personal attack on another commenter, thing that is not really good manner on someones blog.

      1. I’m really not a vegan or die-hard Campbell supporter so I have nothing emotionally invested in that. I’m just trying to find out what all the hub-bub is about since there seems to be a lot of confusion from the followers on all sides. This is the internet and there is a lot of conflicting information out there.
        My question was what do people think she has proved, I made no statement about what I think she has proved. I know what she claims to have proved, that Dr. Campbell doesn’t know what he is doing! Does Denise? Sorry you find my asking that question to be curious.
        I have read a lot of wild stories on people’s websites and blogs and they don’t always match up, no matter what side of the fence you’re on, people are saying crazy stuff. I’m not a pea brain either, but thanks for the personal attack. I guess I won’t be coming back here anymore to have discussions if you want to get all weird about it.

    2. Dr. Eades, you are probably aware of this by now, but in case you’re not, “Amy” is part of the “Blog Bandits”, a group organized by the “Fruitationist” blog “30 Bananas a Day”. (Yes, they really believe that the optimal diet is nothing but 30 bananas daily.)
      Anyway, these geniuses have decided that the way to combat people like you, Gary Taubes, Kurt Harris, Tom Naughton, etc. etc. etc. (and now, Denise Minger) is to create a wall of spam noise on any non-veggie nutrition blog and hope that a non-scientific public can’t tell the difference between the two “sides.”
      My suggestion? Consider flagging such posts in Akismet as “spam” so that these fine folks no longer have their posts auto-approved anywhere on the net, but are instead automatically held in the “probable spam” folder.
      Further, you might consider having your web guy report their IP addresses to their ISP — this behavior is contrary to EVERY internet provider’s terms of service.
      This is a systematic spam campaign and it should be treated as such — by knocking these jerks off the net!

  103. @Amy,
    “It may be a personal bias of mine but I actually prefer to take my nutritional advice from people with real medical degrees.”
    Did I say Denise Minger proved something? Did she? The only thing that was “proven” here is Probability 101 stuff: weak evidence leads to weakly supported conclusions. Campbell, by his own admission in multiple writings, has his own special way of assessing evidence, which apparently only he can do, and which does not warrant explanation of his reasoning processes so others can replicate his results. If that’s not “full of crap”, then what is?
    “Maybe they should enter the field of P.R. and just stop wasting our time.”
    How on Earth can people writing in blogs waste your time? Don’t you choose to spend the time reading this stuff?
    My take on taking advice from others: if you don’t think critically for yourself, you deserve exactly what you get. How can you assess if someone is an “expert” unless you can check that what they’re saying carries evidential weight? And if you can think enough on your own to assess their “expertness”, then do you really need an expert to follow?

  104. @Dave – Fair enough, but I don’t have the time and inclination to go out and research what thousands of writers on the blog-o-sphere are saying, just because someone knows how to get high rankings in the search engines doesn’t mean they have any expertise. Someone says “blah blah person did an analysis”, well unless I think “blah blah” actually knows something I don’t want to spend hours, if not days, reading their diatribes. I do have a life, you know. I’m much more interested to hear what Dr. Eades has to say, or another scientist, or a cancer researcher, for example. I’m not saying that nobody should criticize Dr. Campbell; I just didn’t understand why the Minger thing was given so much emphasis.
    Peace out =)

  105. You can say whatever you want against vegetarianism, China Study and people like Dr. Campbell, the reality proves on and on that a well planned plant-based diet is saving people’s lives and meat eating and other animal food is making people sick. This nobody can deny!!!! This can be seen by everyone on this earth.
    You people with meat between your teeth and mockery on your tongue you don’t know anything else but destroy, destroy, destroy… and take advantage by manipulating people. This is not a fair behaviour toward your fellow, including your families.
    Vegetarianism saved my life and prolonged my mother’s life with 17 years! This is a fact that nobody could deny for me.
    You would better think twice before writting such nonsenses.

      1. What I don’t understand is why the vegetarians even come to this blog and why they think that anything they say will influence us.
        Do any of us regularly visit vegetarian sites and blogs and rail against their lifestyle? I think not.

      2. And how does this poster (Elena) know that she saved her own life and her mother’s life was prolonged 17 years by going vegetarian? Might her mother’s life have been prolonged for 25 years had she ditched the vegetarian diet and instead opted for a low-carb or even zero-carb way of eating? Maybe.

    1. Say what you want about carnivorism but steering clear of a high carb diet with very low or no animal fat and some protein, I have clearly stopped my slide to becoming diabetic. As this is personal testimony by me just as your testimony is by you, neither have have proven anything but what works for us.
      I have read Doctor Eades books and having experienced what it does, I will continue to keep carbs to a minimum by eating those that are VERY less detrimental to what is does to my physiology. So if you haven’t read the Eades’ books, ‘Protein Power’ (more for weight loss, and ‘Protein Power LifePlan’ or Gary Taubes book ‘Good Calories, Bad Calories’ or read up on what INSULIN does and controls, I suggest you do. These tomes all delve with the studies and researches into diet and insulin that an not conjecture and supposition or a study that may have produced a wanted result for someone’s idea that has better chances of being adopted into the federal government dietary programs.

    2. elena,
      That’s odd, I started eating by the Eades ‘Protein Power’ plan in october of 1999 and eating fats from animals and proteins are the major part of my diet and has made me feel better and lose the weight I needed to lose at that time. It is when I revert back to a high carb diet, around thanksgiving and xmas and other family or friend gatherings that I gain weight by retaining water that insulin from eating promotes and I get a general uncomfortable feeling for a few days. After I get back to the basic fat and protein diet, I lose that uncomfortable feeling and have more energy.
      So, on my end, this a fact NOBODY can deny me. What the Eades dared to expose has saved and helped more people than those trying to get their nutrition from a high carb diet.

  106. Elena, your whole, and somewhat elitist argument hinges on those words “well-planned”. You may have a well-planned vege diet, but most vegetarians do not. Most of them seem to think it is a healthy option to eat fries and take the meat out of the burger. Unless you can convince them to plan their diet extremely well, you are doing them no favours advocating vegetarianism.
    If high-tech planning is not your thing, if you tend to just take food as you find it, if Jamie Oliver leaves you cold, then you are far better off NOT being a vegetarian.
    Veganism as practiced by the vast majority of vegans in the developed world is just a socially acceptable form of anorexia.

  107. Anyone who still thinks that meat “angries up the blood” and that a vegetarian lifestyle induces calmness and mental clarity really ought to read Elena’s comment.
    There’s a reason why cults insist on vegetarianism; it greatly facilitates mind control, and makes it easier to create killer zombies if such are needed (just channel that frustrated “food rage” onto the scapegoat of your leader’s choice). Hitler did all his best thinking on a diet of gluten, sugar, beans and salad greens. And suffered chronically from “meteorism”, which is what they called flatulence in his day.
    2 reasons for believing that carbs were not prominent in early human evolution;
    1) saliva contains only one digestive enzyme, amylase: this would hardly be neccesary if carb foods were a staple. The point of this adaptation is to extract some glucose from starch as quickly as possible.
    2) primates do not synthesise ascorbate from glucose. This adaptation trades off the constant risk of scurvy (if the diet is high in carbs) for about 10g of extra glucose (in an animal the size of a human). If carb foods were a staple of early primates, 10g of glucose would not be needed to run a bigger brain and we could have kept the ascorbate. For 10g of glucose to make a difference, our ancestors’ daily carb intake would surely have to below 60g. One consequence of this trade-off is that other primates (arguably) have become more vegetable-dependant, locked into a vicious cycle of high ascorbate intake needed to ward off scurvy induced by high carb intake. Only early humans were ambitious, stupid or idealistic enough to tolerate scurvy as the price of their development, and to find a successful modus vivendi; use the brain to hunt meat, and rely on the largely meat diet to ward off scurvy by conserving ascorbate.

  108. One consequence of the lack of ascorbate synthesis in humans is, that the results any animal experiment (apart from those using primates or guinea pigs) may only apply to humans that supplement gram doses of vitamin C.
    For example, if resveratrol mimics calory restriction in rats, or if cell-phone radiation cures alzheimers in mice, did this effect depend in any way on their high levels of circulating ascorbate, something which you would not find in the average human?

  109. I’m a 61 years young Japanese woman. Run 4 miles daily plus strengthening exercises.
    Since August 2010 have been taking 1 gr Krill oil (Dr. Mercola).
    These are my most recent labs:
    Total LDL 187
    Total HDL 76
    Total Cholesterol 282
    Triglycerides 93
    LP(a) Cholesterol 5.0
    Glucose 88
    Question: Should I increase my 1 gr Krill daily to 1.5 or 2.0 gr so as to reduce my Total Cholesterol?
    Many thanks, Dr. Eades

  110. A google search brought me to this critique of The China Study. I’m still trying to sort out the issues for myself. Despite Dr. Eades claiming to approach the subject with scientific objectivity, as I read his critique I was startled by its tendentious nature — in particular, ridiculing reliance on correlations — including quoting Shakespeare to that effect. Yeah, we all know correlations don’t show causation but you can’t show causation without correlation. Correlations suggest that something is happening. Eades offers no explanation for what that might be. The piece is condescending in the extreme. For instance, he can’t resist inserting contrary comments in brackets in quotes. Then, I take a moment and actually look at Eames website & the book he is pitching. Now it all makes sense — he’s got a vested stake in denigration plant based diets. This is really shameful stuff. It doesn’t help advance the scientific debate.
    I’m very much inclined to trust Campbell.

  111. Diet Poker – will Mike fold.
    I know you think you have a strong hand with the Chiina Study but I am holding the new Dietary Guidelines for Americans. See your obfuscation and raise you ignoring important studies, incorrect interpretation of cited studies, fascist prescriptions (Enjoy your food; eat less), utterly meaningless phrases (nutrient-dense food).
    You still in, Mike?

  112. Plants, animals whatever. It doesn’t matter what you eat as long as you eat a proper proportion of protein, fat, and carbohydrates. There are high quality and low quality foods in both ends of the spectrum. It is better to eat high quality foods with low glycemic index and unsaturated fats. IE green beans are better than bananas and free range game meat is better than fried chicken. Olive oil is better than lard. It is hard for a vegan to get enough protein and not overdose on carbs leading to hyperinsulinemia. As my wise mother used to say moderation is the key and extremism is the enemy. Beside exercise is even more important. I bet Dr. Campbell at his best couldn’t clean and press his body weight which doesn’t make him very functional does it?

  113. Thank you Dr. Eades for critiquing The China Study. I have read it and appreciate a view point from a doctor.

  114. It seems to me that the book is definitely an obfuscation, but I don’t believe that he ever said that it was cause. Readers feel like there is a cause and he strongly believes it animal protein causes cancer, but I don’t believe that he ever said that the research said that it caused. It’s been over 2 and a half years since I’ve read it, but it seems like I remember him saying that this is how he interprets the data. He does so very strongly and that is infused in his writing and it leads readers to believe as he does. Has anyone read it more recently that feels differently? I am clicking to be notified of comments via email so please do respond.

  115. I tried reading through this article but about half way through I tired of hyperbole, smear and personal attack. Very unprofessional. I am looking for a good rebuttal to the material presented in The China Study, as presented by the vegan promoters, but I will have to look elsewhere.

    1. I suspect what you’re looking for is a confirmation of what’s in The China Study. There are numerous posts out there besides mine refuting The China Study. I’ve linked to one. You can find dozens more by Googling if that’s truly what you want to find.

  116. Isn’t that’s what’s wrong with the China study, the hyperbole, smear and personal attack on the Atkins diet. I for one think that if you like a vegetarian diet and you do Ok, you should go on it. Isn’t the point that the China Study is that it ha the one best diet.

  117. One thing is obvious. Dr. Campbell’s conclusions are threatening to your turf and instead of respectfully disagreeing you make it plain that you hold him in contempt in the words you use from the beginning to belittle him and then do everything you can to reinforce that. I’ve seen this tactic used over and over in character assassinations in politics and hostile biographies. I find Dr. Campbell to be more honorable than yourself.

  118. cockatoo,
    I suggest you then read gary taubes’ ‘good calories, bad calories’ if you want to see how the distortion and lies about good nutrition and bad nutrition have been played out in this country for at least 2 centuries with the people touting carbohydrates as the best source, be the as empty as they, of nutrition and will and did prevent the diseased of civilization, particularly diabetes, coronary heart disease, cancer and other. Ancel Keys is the promoter and a shill for the carb industry if there ever was one that kept all the government nutrition boards claiming high carbs and low low fat diets were the healthy diets, never mind the evidence in clinical trials and research to the contrary. Keys was no body’s best friend as healthy nutrition went, he had an ideology and despite the evidence to the contrary, Keys as able to make people and government boards and panels on health claim it so, to the death and suffering of many people who suffered from those claims.
    Taubes does extensive research and reporting in all this and it makes for very interesting reading if you’re willing to read it.

    1. How many people do you suppose have died because of the fried meat & potatoes & gravy – don’t forget the gravy, butter, eggs and ice cream diet we have been sold? My husband, having to eat his real butter, eggs and meat, has in the last four years had a stroke and prostate cancer. I, who have always had a craving for whole grains, nuts and berries, so to speak, and an abhorance of greasy food am healthy, except for some arthritis due to a lot of back-breaking work around this farm over the years.
      We live in Iowa. I am a Wendell Berry sort of person myself, but the farms here aren’t Wendell Berry farms anymore. They are agri-business. Factory farming. Do you have any real idea how disgusting factory farming is? It turns my stomach. The stench drifting in our window on a nice summer evening from a factory hog farm, several miles away also turns my stomach. These animals are given no more consideration than if they were plants, and chickens are the most abused creatures on earth. I used to have chickens around the yard until we got tired of fighting the raccoons for them after PETA declared war on fur and people pretty much quit trapping them. I love chickens. They are dear creatures.
      Well, since his stroke I have gotten my husband to give up butter and eggs and we haven’t had a dish of ice cream since it happened. I don’t forbid him lean meat and some cheese-containing stuff because I don’t believe in forcing my ideas on others. But I don’t hink it is fair that I have to still buy and prepare it either. But that’s my problem. As for me, since I have given up animal products in my diet I have felt really good. My whole system seems to work better and I have more energy and less arthritis pain. I believe in it. I have always been interested in nutrition, sometimes for myself and sometimes for my exotic animals. I have a few books on it. I am not ignorant about eating good whole foods. I also harvest some wild foods that grow on our farm.
      I may or may not read the book you have suggested. It is so hard to sort out who is telling the truth anymore, but I do know this: My teeth much more closely resemble those of a horse than those of a dog or cat. Common sense tells me that there is a message there.

  119. Well said Cacatua. I have been a vegetarian all my life. Raw from 0 -7 and stopped eating cheese at 25 , home made unpasteurized goat cheese before that ( i never liked the taste)
    i clearly remember the last day i had a 4 cheese sandwich and also how my skin was much better after stopping..
    I have always been the most athletic among my peers with abundance of energy.
    The China study like my lived experience proves to me that a diet of whole plant foods is beneficial for satisfaction in life and avoidance of disease.
    The posts that try to defend the continued scavenger life style of cooked animal products all fail an NVC (non violent communication test) and that is good to see , even good to see people looking for honest data and rebuttal are unsatisfied because it isn’t. If you really want to discredit one of the most important studies ever done do your own study with similar variables and allow peer review other wise continue showing your fake ways that only lead to a further discrediting of your rake rebuttal. As somebody who has really done science i am not fooled one bit.

    1. There are a number of athletes and body builders who do very well on plant-based diets, Jonas. I am pretty sure that most, if not all, who have committed to a plant-based diet after reading the China Study are quite interested in nutrition, so they are asking questions and going about it intelligently. At least that is what I see over at the T Colin Campbell Institute. You can be malnourished while eating any kind of diet. I think that many of us there were always interested in nutrition. But a plant-based diet is much kinder to both the earth and animals as well as human digestive systems. I’ve not had heartburn or an upset stomach once since giving up meat, eggs and dairy products.

      1. I agree, cacatua. You can defend the health benefits, or in most people’s cases defense against negative effect all you want. But the fact of the matter is, the systematic production of animals for food is simply inefficient, it is NOT sustainable. Unless you are on your own farm raising and killing your own cows, chickens, and pigs, I would suggest that people re-analyze their belief systems.

        1. You are part right about the systematic production of animals for food being inefficient when you realize the 7,000,000,000 are too many people all looking for something to eat. Wait until the population reaches 10,000,000,000 people and see how things are working out which will just about be like those sorry ‘food industrialist’ trying to grow food for PROFIT and to feed the people.(Intentionally emphasised PROFIT because those industrialist put POFITS above all else and their work is, according to information coming in, not working all that well.

  120. I just read the china study and was impressed with how Campbell decided to remain objective, a scientist, while all around him the politics were menacing and threatening to undo him for wanting the truth.
    It was educational to read how we grew up with certain myths about our food whether it be milk, meat or vegetables, and how much big business controls what we eat. What a scary mess. The children are so unhealthy now – as a 4th grade counselor, it was truly apalling to watch them line up every day for their ritalin pills outside principals office before lunchtime.

    1. “…was impressed with how Campbell decided to remain objective, a scientist, while all around him the politics were menacing and threatening to undo him for wanting the truth.”
      You know campbell wrote the book himself, don’t you? You make it sound like an autohagiography.
      Just because they’re out to get you, it doesn’t always make you right. Or objective. Campbell ignored the biggest finding in the “real” China Study in the book he wrote about it; that wheat consumption is associated with an increase in heart disease of 65%.
      Instead he selected out dubious proof of his own prejudices re: animal protein.
      He didn’t let the facts get in the way of a good story.

  121. People will debate and argue about nutrition for decades to come. Perhaps until the human race is no longer.
    I am a little over half way done with Campbell’s book, and so far, I have learnt quite a bit. I find some of his sentences written in a way that may be considered manipulative. However, I feel he persistently states in his book that these are, in fact, correlations, not causations, and they ‘show’, ‘link’, ‘suggest’, etc. a certain outcome. He does not say that they definitely will.
    Also note that Campbell began his research with a bias against vegetarians and supportive of an animal-based diet. He stood by his belief until his findings had been strong enough to sway his opinion into the other direction. Why would he risk his notoriety for suggesting a plant-based diet superior to an animal-based diet? And for what? It is clear that the evidence he found supporting a plant-based diet, at least to him, was strong enough to make him a supporter of such a diet.
    I feel, for my age, that I am very well-read on nutrition and diet. I know more than most adults, but also realize that I have a lot to learn on the matter (I also feel that society itself has a lot to learn).
    We cannot deny that humans need micronutrients and macronutrients. We can argue about what is best: a high carb, high fat, or high protein diet. We can argue about whether we need all the amino acids in one meal or not. we can argue about vegan versus meat…
    I feel it is clear, however, that we need to eat varitey, we cannot survive without plants, we need micronutrients, and we need all of the macro nutrients, including each of the essential amini acids.
    Plants can provide all of these. Animal products alone cannot.
    Plants, in their wholesome state, offer significantly high amounts of micronutrients per calorie. (I mostly refer to fruits and vegetables, as I do not believe grains should be part of the human diet). This could be related to why plants have been found to reduce rates of disease and provide more energy. Antioxidants, vitamins, and minerals can combat all of these things. Perhaps this is the reason why so many have claimed that a raw diet is superior and why many are making the switch to one: they retain as many of the plant’s nutrients as possible, therefore, maximise the amount of nutrients a person will digest.
    Studies can relate facts to outcomes, but it takes years, maybe decades, to cement a belief that it is ‘nearly definite’ that a cause is the reason.
    I find information published by scientific research interesting and indulging, however, it is so often misleading. Too many companies, including the dairy and meat industry, finance studies to support their product, principle, ect.. If the outcome does not provide what they had intended, the study is dismissed and does not reach public view.
    What I value more than any research done by scientists is personal experience- most importantly that of first-handed experience.
    I became vegan almost a year and a half ago in an unconscious effort. I found myself with more energy than I have ever had in my life; I slept better and woke up earlier (often before 7 am for a teenager). These feelings are still prevelant today, and I have never had any desire to return to neither a vegetarian diet which includes dairy and/or eggs, an omnivorous diet, nor a diet including meat but excluding eggs and/or dairy.
    I have enganged in many conversations with others who have had similar instances regarding diet, which further cement my belief in the superiority of a plant-based diet.
    A vegan or vegetarian diet can easily be done wrong. False meats, cheeses, and other products have become increasingly common in supermarkets (a fact I am unsure whether to be happy or upset about). Despite what the labels say, these foods are not healthy. They can be locally made, homemade, non-GMO, etc, but they will be non-beneficial to health. These products, along with breads, refined grains, and other processed foods are the reason why so many vegetarian diets can fail.
    Fruits, vegetables, nuts, and seeds are really all the human body needs.
    We are omnivores, however, and so we can survive on a wide range of food, including dirt, dead leaves, bone marrow, and tree bark. Being omnivorous is a gift in that respect, but there is a difference between surviving and thriving.
    I most definitely feel I am thriving. I have regarded both sides of the argument. If my body is right, then I am making the right choice by being vegan. I love it. ☺

  122. Please read this link
    “Campbell’s animal research has, in fact, raised critically important questions about the ability of dietary protein to promote the growth of cancers once they are formed. His failure to tell us that high levels of dietary protein offer equally dramatic protection against the initiation of cancer and that rats fed low levels of protein have many health problems of their own, however, unfortunately obscures the true importance of his work.”
    In This Blog Post
    •An Obscure Study From India — Low-Protein Diets Save Rats From Cancer But Kill Them Instead
    •Campbell’s Protein-Deficient Rats
    •Protein Deficiency Disappears Down the Memory Hole
    •The China Study’s Best-Kept Secret — Protein Protects Against Cancer Initiation
    •Plant Vs. Animal Protein — Campbell Proved There’s No Difference
    •It’s All About the Mechanism

  123. I actually feel sorry for Campbell. He threw away whatever credibility and respect he once had publishing and then attempting to defend his propaganda piece.

  124. Dr. Eades,
    Just a heads up re. an online discussion accusing Dr. Masterjohn, Denise Minger and you of misinformation.
    These comments were in response to Dr. T.Colin Campbell’s critique on The New Atkins Book in an Amazon discussion.
    This thing is getting bloody doc, we could sure use your help in correcting these accusations.
    posted Dec 13 , 2011 – 5:04pm pst
    “… If Chris Masterjohn wants to be taken seriously he needs to correct his misinformation about Dr. Esselstyn. And if Denise wants to be taken seriously, she needs to get her facts straight before she tires to change the world. The same goes for Dr. Eades. These people are slinging misinformation like hash. They may influence a few people at first but in the long run people will stop trusting them.

  125. Your counterpoints are as weak (if not weaker) as Campbell’s points you are trying to refute. Your unprofessional put-down language tips the scale towards Campbell’s arguments. A thoughtful person can rely on thoughtful arguments. You just sound like some kind of a sore loser.

    1. Yes, that’s what I was thinking. My thinking is that the connection to meat is more emotional than nutritional. But try to tell this to a ‘religious’ meat-eater…

  126. After watching the “Forks Over Knives” documentary, my wife (a scientist by profession) and I (a cynic) wanted to see who had sponsored the film, a la PETA and “Supersize Me”. It sounds like there is at least some credibility issues with Dr. Campbell’s studies, which helps explain how he was so ready to tell the world that big business and the USDA were ruining him, an excuse usually used by practicioners of bad science when they are rebuked by their colleagues. Thanks for doing the leg work on this. I won’t buy the blog wholesale, but I’ll cancel out the documentary as well and shrug my shoulders at the whole argument.
    Very liberating. Thank you. 🙂

  127. Every animal on the face of the earth knows what to eat, with one exception.
    Isn’t it strange how the most sophisticated creature doesn’t even know, or can not come to agree with the topic of diet.
    Structure governs function.
    Learn this, you also learn if your diet & lifestyle theories are close to true.
    Thank you drive through.

  128. Another take of The China Study vs. The China Study is The China Study: Proof or Propaganda at theboomerpost.com. I read Dr. Campbell’s book cover to cover, took notes, and found internal inconsistencies and over the top pronouncements such as eating animal based foods can cause blindness.

  129. Hello Dr. Eades. I’m a big fan. I’m amazed at your critical breakdown when it comes to faulty science. I’ve started a low carb blog recently. I’m mostly focusing on food recipes and weight/athletic training while on a low carb/ketogenic diet. Your book(s) and blog have been extremely helpful for me in building my resources and references page. Thanks for everything you’ve done in the medical community!

  130. Yes and for years the tobacco industry used this same (correlation is not causation) argument to defend its product and marketing practices until it could deny the reality no longer. Undoubtedly Dr. Campbell’s studies are not definitive, but they certainly lead one to ask some useful questions and to challenge the glut of misinformation we have been fed for decades by various food and pharmaceutical industries with self-serving motives.

  131. Many medical experts say vegetarians are generally healthier, but people who are conscious of their diet are less likely to eat junk foods and rubbish. There is inceasing evidence that a hunter a gather diet (ie no processed foods or grains, and therefore low carbohydrate) is superior to all. Agricutural meats are high in fat, hormones, and changed chemical structure due to feed. Cows are meant eat grass not grain, chickens are meant to free range on insects as well as wild seeds, not just grain pellets. This makes them high in omega 6 instead of omega 3. Game meats such as venison, kangaroo etc are generally 98% fat free and have a higher protein and nutrient ratio to agricultural meats.

  132. I just read through your critique. I agree with one of the previous comments: the immature, polemical, and sloppy quality of your critique does less to discredit Campbell book than it does your critique.
    Campbell’s book cites hundreds of studies and deals with a large range of issues. You’ve ignored all of it to provide some really lame and utterly subjective rhetorical analyses of “obfuscation”.
    You do realize that it’s possible to publish a serious critique of a scientific study, right? Scientists do it all the time. Campbell himself published a critique of the Nurses Health Study in the American Journal of Clinical Nutrition (if I remember correctly).
    What scientists don’t do is produce childish polemics that have nothing to do with science. I looked you up on Google Scholar. You haven’t published any scientific research papers at all. That says a lot.
    It would be much more interesting and worthwhile to produce an intelligent and substantive critique of his book, because what you’ve produced above certainly isn’t intelligent, scientific, or substantive.

    1. I’m a clinician not a bench scientist – there is a difference. But that doesn’t mean I can’t see lousy research when I find it. And your search on Google Scholar was incomplete as I have been published in the scientific literature.

        1. Are you responding to Mike’s comment or to someone else’s? Be good to learn common-sense rules of grammar (and maybe some common courtesy into the bargain) before yelling at whomever on this website. Who’s an idiot? And does all tweeting and emailing make someone an idiot or is it just the assumption that “they forwarded info” (whatever that means) that renders them incapable of being intelligent? Clarify, why don’t you?

          1. All that comes up is ONE publication. I repeat: one publication. All this tells me is that you’re a zero of absolutely no relevance to medical and nutritional science.
            Seriously, were you hoping to somehow impress me with your one publication, in which you weren’t even the primary author?

          2. I’m not trying to impress you. In fact, I don’t give a flip about whether you are impressed or not. I told you I was a clinician, not a bench scientist. I did start my scientific career in a PhD program, but I switched to medical school. You said I wasn’t published; I pointed out that I was. Although it is a single paper, and although I’m not the lead author, it is a published paper that I participated in. The vast, vast majority of clinicians don’t have a single paper to their name in the scientific literature.

          3. Dr. Eades, Thx a lot for the tip. I didn’t realize hemorrhoids drink bear. Now I’ll be on the look out. 😉

          4. Right, so since are a clinician and not a bench scientist, what business do you have making critiques on the scientific validity of research studies?
            Would you allow a bench scientist with no clinical experience to critique your diagnostic skills/experience as a physician?
            In other words, you have almost no experience designing scientific studies, and therefore, you are an armchair critic and nothing more.

          5. Because, believe it or not, clinicians can read. And although I am a hands-on practicing physician, I’ve spent the last 25 years of my career attending scientific conferences and reading the scientific literature. You?

          6. I believe you. I’ve also read the scientific literature and attended scientific conferences. I know I’m being critical of you, and I know it’s easy for me to criticize you anonymously on the internet, and from what I’ve seen, I think you have good intentions, but you have not spent your career designing experiments and therein lies the problem. I am not trying to be condescending when I say this, but you are suffering from confirmation bias. You have a hypothesis, and you have found and continue to search for evidence that backs up this idea that carbs are the enemy, and we should be eating more fat and protein, when in fact, Americans are some of the largest consumers of animal products in the world, and are probably the most unhealthy people with the possible exception of certain pacific islanders (Republic of Kiribati for instance)
            Dr. Eades, hypothetically, if a non-physician public health researcher or even a nutritional epidemiologist were to write books on how to diagnose and treat patients, and those books contradicted currently accepted best practices, and you knew (from your extensive training and experience) after reading the books that the author actually misinterpreted a lot of things and did not have a clear understanding of the subject, what would be your reaction?
            The question of what constitutes a healthy diet can only be answered by those who dedicate their lives to designing and conducting empirically-based epidemiological studies on nutrition. These are undoubtedly expensive, complicated, treacherous, and oftentimes ambiguous, but they are our only shot as a society of getting answers. Are high-fat, and high-protein diets proven weight-loss techniques in the short run? Absolutely. But are they healthy in the long run? The answer seems to be no, according to HSPH as well as several other academic centers and the USDA (not a fan of them). In other words, mainstream public health research does not agree with you. If you were a professional researcher, you would be in the loop contributing to solving this problem, but like me, you are just another armchair critic who’s out of the loop. Unlike me, you write best-selling books that contribute to the flood of misinformation out there and people listen to you instead of the researchers actually on the front lines. Like practicing medicine, don’t you understand that it takes more than just reading the literature and attending conferences to become an authority on nutrition research?

          7. I appreciate your taking the time to lay out your argument as to why I am unqualified to make an intelligent critique of someone who is a ‘real’ scientist. As you might imagine, I encounter criticism and argument all the time. I don’t mind it, and I enjoy the back and forth. It helps me refine my own arguments and often opens my mind to other points of view. But I have also engaged in discussions/arguments involving politics, nutrition and a host of other controversial subjects that lead nowhere because neither side can be persuaded. I’ve learned to assess early on which arguments are headed in this direction. Whenever I sense a discussion is headed down this path, I always ask what kind of data/evidence/proof it would take to bring the person I’m dealing with around to my way of thinking. Typically, the respondent replies that there is no amount of proof/evidence, etc. that would be persuasive. When I get that answer, I disengage because the discussion is pointless.
            I sense I am there with you, so let’s just agree to disagree.
            I do want to make a couple of points, then you can use this comment forum to have the last word.
            Before I went to medical school, I was in a PhD program in one of the basic medical sciences. I decided after a couple of years in grad school that I would probably enjoy medicine more, so I switched. But in the two years I spent in the PhD program, I did get a fair amount of lab experience and tutelage in the scientific method, so I’m not a total tyro. I am close friends with many bench scientists who do spend their working lives doing experiments. We discuss this often, and I can assure you that these people – who are skilled, working scientists in major universities – would not say that I am incapable of reading and understanding a scientific paper or that I’m clueless as to how experiments are set up and executed.
            As to my having a confirmation bias… We all have a confirmation bias. Do you think you’re free of it? Anyone who is in an argument can accuse his opponent of having a confirmation bias. The real issue is whether or not one can overcome a confirmation bias with new data presented.
            I’ve got 25 years of direct patient experience dealing with probably 10,000 patients using low-carb diets. Based on my experience, I’ve developed a bias that cutting carbs is the most efficacious diet for weight-loss and health for the majority of people. That doesn’t mean some people won’t do well on other diets, but that most do better on low-carb. When I saw these results first hand, I went to the medical literature to figure out why it worked so well.
            The China Study, of which I assume you are a big fan, is simply an epidemiological study, and as such can’t prove causality. As Dr. Campbell reported in his own book, his own colleagues, who were themselves ‘real’ scientists, disagreed with his approach and thought his data would be worthless. They were right. It pretty much is.
            As I said, I’ll give you the last word.

          8. Fair enough. The China Study is not worthless, but you’re right that neither does it prove causality. I’m not a nutritional epidemiologist or even an experienced statistician, so I cannot comment on the validity of Campbell’s research findings. But many of his conclusions agree with other epidemiological studies that were performed in the US by leading institutions. The data seems pretty clear that red meat, saturated fat, and refined carbohydrates (high glycemic index) are not associated with favorable outcomes. Vegetables, fruit, beans, whole grains, and nuts are associated with favorable outcomes. I am not interpreting data here, just regurgitating what leading researchers have published. Yet you seem to be in favor of eating more red meat, saturated fat, and less whole grains. You have to admit that these are pretty significant differences…This is why I think physicians and nutritional epidemiologists should form research partnerships.
            “We discuss this often, and I can assure you that these people – who are skilled, working scientists in major universities – would not say that I am incapable of reading and understanding a scientific paper or that I’m clueless as to how experiments are set up and executed.”
            You have theoretical knowledge, but no actual practical experience in nutritional epidemiology or public health research. There is a big gap for everyone between theory and practice, and these are complex fields that are much different from basic science research. Hypothetically, if we could have a randomized controlled trial for 100,000 people over 20 years and put half in a no red meat group and the other half in a red meat group and strictly control what everyone ate, we would have a pretty clear result, but a study like this is impossible to accomplish. The next best thing, observational studies, are not as robust, but the power of large sample sizes should not be underestimated either, and I think that’s what you’re doing because these studies seem to run counter to your personal experience. Have you developed diet questionnaires? How many of your 10,000 patients have you regularly surveyed, and how long have you monitored each patient and low carb dieter over 25 years? If you have done any of this, have you also had a statistician compile and analyze your results and do you know where the pitfalls are in all of this?
            My point is, your personal experience with patients is very similar to these observational studies you seem to dismiss. Unless you have been extremely rigorous in compiling your data and have followed your patients for at least 10-20 years, you cannot safely conclude that low carb diets that include lots of red meat, saturated fat, and few whole grains are beneficial in the long run, especially when many studies indicate just the opposite. In the short run, you may have observed that they seem to work for weight loss and other problems, and the research seems to back that up, but how many of your patients develop other long-term problems as a result? What I am saying is that you have opinions about what kind of diet is healthy, safe, and effective in the long run, but you have no real evidence to back up those opinions, and they run counter to the findings of the best observational studies.
            “Going to the medical literature” does not make your opinions all of a sudden become scientifically rigorous and consistent. Your opinions may seem more convincing to you after reading the medical literature but others may be more convinced by other studies that you choose to disregard.

          9. One problem with this debate is that it is limited to cancer, and doesn’t address heart disease. Dr. Eades could work with patients for decades and be totally unaware that his dietary recommendations mean that his patients’ heart disease is steadily worsening.
            Clinical, experimental studies, such as those done by Esselstyn and Ornish, find that heart disease is reversed by diets that involve little or no animal products, and with the best results coming from consuming no animal products. Diets high in fat and animal products means that heart disease gets worse.
            Furthermore, Dr. Eades is conveniently ignoring the fact that when populations switch from a very low fat plant based diet to a high fat animal based diet, all the diseases of affluence increase dramatically–heart disease, diabetes, cancer, etc. This is what is called a natural experiment, and it is often one of the best sources of evidence scientists have.
            These populations with great health outcomes eat very high carb diets, so it’s difficult to argue convincingly that good carbs are the problem–especially if we understand that the point is to discuss complex carbs, not the simple carbs at the heart of the American diet.

          10. This is all nonsense, of course, and not backed up by any credible scientific evidence, but far be it from me to deny you your soapbox.

          11. I did a search on PubMed. All I found was a pathetic ONE publication, in which you aren’t even the primary author. Is that supposed to be impressive? ONE publication? Really?

        1. belgian beer, a bit heavy handed on your cognitive dissonance aren’t you. That Dr. eades answered you with 5 words of instruction should preclude you from wasting more time and space on this site. So go have another beer, it’ll do you wonders.

          1. What are you talking about? This little man claims to be qualified to critique the research of highly accomplished scientists. When asked on what basis he presumes to have any authority or competence to conduct such a critique, the best he can provide is a paltry, utterly laughable *one* publication, in which he isn’t even the lead author.
            And, you rush to the defense of this little man? That speaks volumes about your own intellectual integrity.

          2. I am talking about someone who knows far more than your cognitively dissonance will ever understand. Sad to see ignorant people presupposing to be experts, but you don’t even come close. I KNOW what both Dr Eades are talking about and understand it with the help of Gary Taubes and Dr. Robert Lustig. Your spouting off from empty air. Oh, btw, I have personally experienced what Dr Eades promotes for good health and proper nutrition which works like a charm.
            So beer belly, you need to get a job at a service station filling up flat tires with all your hot air.
            I beg Dr. Eades pardon for that comment about hot air but belly beer does try to be and expert here about this and it isn’t working, at least for me what he says.

          3. Oh, I forgot about Dr. Eades major publications. ‘Protein Power’ and ‘ProteinPower LifePlan’

          4. You can’t link to any peer-reviewed scientific publications in respectable journals, so you link instead to a YouTube video?
            I can’t tell if you’re serious or if you just have a great sense of humor.

          5. Actually Dr Ludwig in the video is very well regarded in his field and respected, even by opponents – of course published countless publications, not necessarily a direct rebutal to Campbell, but refute Campbell’s assertions. numerous times. To address your insinuation that no “qualified” professional has ever refuted campbell – What a load of you know what. There are various Dr’s, researchers, and including one former vegan who refuted practically every point Campbell made and demonstrated he mis-cited many of his sources – But since you are adament on your position, here you go Hu FB, Willett WC. The relationship between consumption of animal products (beef, pork, poultry, eggs, fish and dairy products) and risk of chronic diseases: a critical review. Cambridge, MA: Harvard School of Public Health, 1998

          6. Ah. So, you’re really good at (trying to argue using) the totally flawed argument technique called “Appeal to Authority”? You can’t argue the science, so you suggest the ‘proof” is in credentials?! Yup, that sure speaks volumes about YOUR (lack of) intellectual integrity!

          7. Thanks for that link, I found a lot was interesting and especially the beauty or idol contestants trying to construct meaningful rhetoric. Of course the shows it self may have had some input in how to answer questions but besides the entertainment part, more worrisome was the inability to articulate or just a total lack of knowledge.
            Even ran up on an old one I had seen a while back where the newly wed game woman had to determine if her husband was urban or rural.

          8. Oh, belgian, you still here? I gave evidence, you ignored it and still you continue your homilies.

          9. Which leaps and bounds above your antagonistic calcified cognitively dissonant brain. Hard to tell if you have had total or complete frontal lobotomy recently. Of course it could have something to do with all that alcohol you drink. And what a come back, ‘What are you talking about?’ only proves you brain is over soaked in alcohol.
            He is qualified just as/was dr. atkins and many other nutritional doctors. But you speak of “critique the research of highly accomplished scientists”, just who would they be?

          10. Hey Mike,
            Isn’t this blog moderated. I know, it gives you a laugh but the serious part is that I’m losing my taste for Belgian beer.

          11. Yeah, I know. I need to start trashing these comments. But I’m such a fair-minded guy that I hate to not let some hemorrhoid have his say even if it’s slagging me.

          12. One does not have to spend one’s life publishing research to make the point this man has made. It’s Statistics 101, sir. It’s lesson 1-10 in any basic research course. Just because murders and ice cream are both more common in the summer months does not mean ice cream causes murders… Correlation does not equal causation. It is the basis for forming a hypothesis, not a conclusion. Dr. Campbell is simply stating his hypotheses and calling them conclusions in his book, and morons like you are eating it up. Bravo.

  133. Just wanted to say thanks for this article! I am ashamed to say that I was one of those uncritical thinkers who loved TCS and told everyone about it. It now makes me angry to see how the ‘good doctor’ Campbell would abuse his position to deceive a trusting public.

  134. Dr Eades, I am from India and the section that interested me most was the peanut (what we call groundnut) aflatoxin connection. Groundnuts are an intergral part of the Indian diet so incidence of cancer from Groundnut consumption must be statistically significant. Is it so? Being a layman who has considerable difficulty (!) in making out scientific Dutch and Greek (jargon), I leave it to better heads to find out. But going by Dr Campbell, aflatoxin is certainly “carcinogenic”.
    However even these better heads will need to get around this fact: Indians prefer having groundnuts in a variety of cooked forms (not raw). Groundnuts are consumed roasted (with or without oil) or roasted and applied with turmeric or chilly or roasted in jaggery or boiled in water (to which a pinch of salt has been added) in their shells or simply added to the various curries and gravies we make to go with our rice or bread. What will be the impact of these various forms of cooking on the aflatoxin content of groundnuts?
    And talking of rats, why not choose another animal – the shark? Sharks have been shown to be notoriously resistant to cancers of any form, despite being exclusively carnivorous. An, indepth analysis of the biochemical processes within sharks would have been of more benefit; a cause-effect formulation could have been arrived at, rather than the mass of empirical evidence presented.

    1. Sharks do in fact get cancer.
      in 2004, Dr Gary Ostrander and his colleagues from the University of Hawaii published a survey of the Registry for Tumors in Lower Animals11. Already in collection, they found 42 tumors in Chondrichthyes species (the class of cartilaginous fish that includes sharks, skates and rays). These included at least 12 malignant tumors and tumors throughout the body. Two sharks had multiple tumors, suggesting they were genetically susceptible or exposed to extremely high levels of carcinogens. There were even tumors found in shark’s cartilage! Ostrander hoped that this information would finally put to rest the myth that sharks are somehow magically cancer-free.

  135. I believe that optimum diet is arrived at on an individual basis. Whats good for Jack may not be optimum for Jill. You must study your own body not someone else’s.
    I have arteriosclerosis, complete with stents and by-passes.I followed Atkins and Eades for about 15 years while going thru this surgery.When I switched to Campbell and Esselstyn diet my problems were greatly alleviated . Protein Power may be great for you but it almost killed me.

  136. I wonder i Dr. Campbell missed the Buddhist monks when he studied China diet. Most of Buddhist monks are vegan for life starting when they were very very young, but they are still fat, have cancer, and chronic diseases.
    What are the explanations for this? He did not have to spend a fortune to complete the research!

  137. Just a few comments to Greg. I never really thought Mike Eades needed any defense but sometimes you can’t resist:
    1. Credentials are not part of science. You can be a clerk in a patent office in Switzerland without a PhD and if you have something to say people will listen; credentials are in the contribution and the quality of the work.
    2. In addition to the major researchers in nutrition, Volek, Phinney and related, I personally trust Dr. Eades’s analysis and interpretation, notwithstanding that his blog (and mine) have a certain degree of license.
    3.”Confirmation bias” is the very hallmark of traditional nutrition.
    4. I don’t know that my own credentials give me any rights either but studying chemistry, that is science, is different than getting an MD or MPH. And I, of course, am a real modern scientist since I was funded for twenty years by the NIH.
    5. I’ve worked in protein chemistry, enzyme mechanism, blood coagulation, platelet physiology, behavioral neuroscience and interact with people from other fields. Nobody in those fields would touch establishment nutrition.
    6. The output of HSPH, USDA and AHA have produced the most dreadful kind of pseudo-science.
    7. In a field like that, “currently accepted best practices” are exactly the trouble.
    8.”Those who dedicate their lives to designing and conducting empirically-based epidemiological studies on nutrition” are the major cause of the problem because they have no training in experimental design and they conduct in the most mechanical uninspired way.
    9. There is no reason why an MD can’t do scientific research but having an MD by itself is no guarantee of anything outside your specialty.
    10. People in fields related to nutrition, metabolism and physiology recognize right off that there is little science in the field of nutrition.
    11. I and my colleagues are surely exceptional human beings for even thinking that we could change things.
    12. The kiss of scientific death is “according to HSPH,” Hundreds of millions of dollars have probably been wasted on drone-like plugging data into a computer and coming up with odds ratios of 1.22 so we should eat brown rice, no meat, no aspartame, no refined this, refined that. Nothing of import has ever come out of HSPH beyond the demonstration that carbohydrate is worse than fat for CVD. I recommend my blog post on “Crimson Slime” http://wp.me/p16vK0-cM where they plead Nolo Contendere.
    13. And, they have been good at squelching other research. Although you can find out who they are sometimes, in their critique of other work, in journals and study sections, like you, Greg, they hide behind anonymity.
    14. In the end, these authorities are amateurs who have made up a bunch of rules with the self-serving title of “evidence-based medicine” without any real understanding.
    I have previously made the analogy with the apocryphal story about Mozart which I repeat here:
    A man comes to Mozart and wants to become a composer.  Mozart says that they have to study theory for a couple of years, they should study orchestration and become proficient at the piano, and goes on like this. Finally, the man says “but you wrote your first symphony when you were 8 years old.”  Mozart says “Yes, but I didn’t ask anybody.”
    15. Finally, the meaningless output from HSPH and AXA (X= A, H, etc.) are also put into policy. If we can accept, thanks to Seinfeld, that being a food-Nazi is different from being a Nazi, these guys are food-Nazis. And it is remarkable to see all these people Sieg-heiling. Obesity epidemic, thy name is Greg.

    1. You have an interesting website…I have read some of your articles and plan to read the rest shortly. I particularly liked the one on the DGA report, you raise some very valid points…
      I would like to point out a couple things though:
      1) You lump HSPH with the USDA when Walter Willett is actually one of the staunchest critics of the USDA food pyramid. HSPH encourages consumption of unsaturated fats, fish, and chicken, but they do specifically discourage red meat, saturated fat, and trans fats. They also encourage whole grains, and they specifically define what those are on their website: whole, unprocessed grains like steel-cut oats, buckwheat, etc. They do not encourage eating sweetened, fortified cereals or other processed foods. You might object to their recommendation to eat whole grain bread, however. This would, in fact, suggest that HSPH is not in bed with Big Ag…contrary to what many of your readers seem to think.
      2) You obviously don’t think much of nutritional epidemiology as a field…In your opinion, should we should just scrap the entire field? Should we just rely on basic science research? According to you, what would be feasible in terms of experimental design to understand the long-term impact of eating red meat, saturated fat, and dairy products? No disrespect, but how long will it take scientists like you to elucidate how much of what foods are healthy in the long run, and what we should be eating on a daily basis? Do you think this is a question that is best answered by basic science research or empirically?
      3) I doubt you will give this much weight, but HSPH’s current recommendations happen to agree to a large extent with traditional Chinese medicine, Ayurveda, as well as the dietary customs of many old cultures. Not too long ago, there was no science, and people had to rely on empiricism. I have lived in China for 3 years, and although Chinese people are getting unhealthier now, there is no other civilization that is as fixated on the link between food and health as the Chinese. I can tell you for a fact that red meat is not recommended for regular consumption and neither are dairy products, Although they can both be used medicinally by those who are thin and/or in need of concentrated nutrition. Oil (unsaturated fat) was and still is consumed in generous amounts. Chinese people used to eat only whole, unprocessed grains. Milling technology obviously changed that, but the Chinese government is now apparently trying to get 15% of rice consumption switched to sprouted brown rice by 2015.
      4) As a scientist, can you show me any evidence that indicates that red meat is a superior source of animal protein to chicken and fish? Can you show me any evidence that shows that saturated fat is superior to unsaturated fat? Common sense dictates that if there is some evidence (no matter how unconvincing it might seem to you) that both red meat and saturated fat should be limited or avoided entirely, and there is no evidence that they are advantageous, it seems wise to limit or avoid them, although I am open to hearing evidence to the contrary…

  138. Well greg, and I know it is a bit of an old study and research and I have practiced it and I’ll be dawg gone if it does not work for losing weight but also for maintaining optimum health.
    It is the works of Vilhjalmur Stefansson back in the day of the1930s or earlier or his field experience of the inuits dietary habits and health. And quickly just to give you link to Stefansson’s own personal research with a fellow researcher of this ‘experiment’:
    Adventures in Diet
    Part 1
    By Vilhjalmur Stefansson
    Harper’s Monthly Magazine, November 1935.
    Trying to keep up with this current tread is not what I relish and I have used this link to inform people of just what and how the ‘modern’ version of the paleolithic diet still stands.

    1. Jon,
      For your sake, I hope you’re not eating a no-carb, high protein, high fat diet. Human beings are not carnivores. Incidentally, the Inuit have terrible life expectancy, and so do the Maasai and Mongolians, two other indigenous groups that eat lots of red meat and dairy products. The reason I raise objections to diets high in red meat, saturated fat, and dairy products is because the long term safety of these diets is unproven and there is evidence from observational studies that they are unsafe in the long run. Why would you eat such an extreme diet? Lots of civilizations have a long history of eating a broad and varied diet of whole grains, vegetables, legumes, nuts/seeds, fruit, poultry and fish, with red meat such as beef and pork and dairy products consumed only occasionally if at all. In my opinion, a varied diet is crucial because it’s an insurance policy against deficiency in any one micro/macro-nutrient. Eating only meat and animal products ensures that you will miss out on hundreds if not thousands of potentially beneficial micro-nutrients in the plant kingdom…

      1. Basically, except for a few leafy greens, thanksgiving and xmas, I do my best to stay away from carbs. When I gave them up in 1999, I was really amazed at how well I felt after about 7 days. Lipid profiles have been in the good range and steady. Why would I change. ‘Protein Power’ DEFINITELY prevented me from becoming diabetic. I owe both Dr. Michael and Mary Dan Eades all the gratitude I can give them, but my brother who called me in 1999 and told me to just read the first 100 pages and see if I did not fit the profile he is who I really thank. I did. I lost weight and my doctor was amazed at how good my blood work became. Just know you can’t stand to hear that but listen to this.
        In 1985 as I was waiting in the lounge while my truck was being serviced, I happen to catch part of a Phil Donahue show with Linus Pauling and Jack Lalanne. Of course I exercised and it worked but this is about Pauling recommending in his book ‘How to live longer and feel better’ to take optimum amounts of vitamins and minerals. I was amazed at how well I felt about 3 days after starting on that regimen.
        My only serious issue was a melanoma my dermatologist found on my back of my left arm/shoulder.
        So don’t go preaching your scare tactics at me. I feel fine and if I eat just some fruits or grains and even some of the leafy greens I GET GAS.
        Just for a little bit of information. One if there is a perfect food, EGGS are it. Two, If you are not taking an adequate amount of magnesium, you are not in the best of health.
        But since you are replying to my comment on the Stefansson link, I can tell that you did not read it. Or it revolted you. I sure wish you would explain why Stefansson was just so damn wrong. He is not and neither were the indigenous tribes all around the would until they began to use agricultural foods. That period in time is so well documented as the break when all those ‘diseases of civilization’ showed up in humans so explain that. AND if you don’t read the link I sent, do not bother to respond and try and tell me that I will be dead by tomorrow because I don’t eat like you want me to eat. What you conveniently leave out of your lecture is the body’s need for Saturated, Monosaturated and Polyunsaturated fats. So, as the Eades’ book ‘Protein Power’ was so helpful to me and my health, I have trust enough in it to continue eating as spelled out in that book. You might do well to also real Gary Taubes ‘Good Calories-Bad Calories’, otherwise you are just Ancel Keys reincarnate.

        1. Fats are important. There can be no doubt about this. Dr. Eades and others are right to point this out. Leading academics in institutions such as Harvard are in favor of monounsaturated and polyunsaturated fats. Human beings have a long history of safely consuming high quality, unrefined extra virgin olive oil, peanut oil, and sesame oil among others. Today’s refined oils, especially canola, safflower, soybean, and others, are probably best avoided due to the extraction process which creates trans-fats and strips away protective phenols and nutrients and are probably behind many health problems. Organic clarified butter (ghee) from pastured cows is also safe to consume in small amounts as attested by Indian cuisine and Ayurvedic medicine.
          The problem, in my opinion, would arise when no whole, unprocessed grains and legumes are consumed, and fat, oil, and meat supply the majority of calories. I am not trying to scare you, only to share my perspective on the issue (I visit this blog and others to give and receive various perspectives on nutrition) If you were extremely unhealthy before starting your current diet, I can understand how your current diet might improve your health…for a while. But the whole “paleo” justification is very tenuous at best. There is archaeological evidence to indicate that human beings were once grain foragers before civilization. Also, we have many times more copies of the amylase (enzyme that breaks down starch) gene in our DNA than our closest relative, the chimpanzee, suggesting that underground storage organs like starchy roots, tubers and bulbs were and still are an important source of nutrition. Check out Plant Positive’s youtube video series examining the validity of the paleo diet…he is a vegan (I eat meat) but he uses only peer-reviewed journal articles to disprove the idea of diet based on evolutionary theory…Contrary to what you might think, anthropologists only have hypotheses as to why human beings developed the way they did and what they ate before civilization. The man the hunter hypothesis is just that…there are many competing hypotheses, and you should explore them before basing your entire diet and existence on one idea…
          If you eat fruit at the same time as meat or fat, anyone would get gas because meat/fat take a longer time to pass through your digestive tract and in that time, the fruit undergoes fermentation in your intestines, releasing gas…which is why it is best to eat fruit by itself. Also, if you rarely eat whole grains, legumes, vegetables, and fruit, you will get gas initially because your bacterial flora are not used to digesting these foods. Over a couple weeks, though, gas should almost totally cease. A little bit is normal…even animals fart 🙂
          I had read the link you sent me at least a year ago, and am quite familiar with Stefansson. I’m a fan of the guy, but some of his ideas on diet/nutrition are way off. The extreme no-carb Eskimo and Inuit diet works to a certain extent in polar climates because of the extremely cold temperatures which necessitate much higher caloric intake to adequately warm the body. But you really should take a look at some of the data on these indigenous tribes. All of them have much shorter life expectancy than people in the US and suffer greatly from cardiovascular problems (http://www.diseaseproof.com/archives/diet-myths-do-primitive-peoples-really-live-longer.html) and even osteoporosis due to the acidifying tendencies of meat which leaches calcium and other minerals from bone. This has been demonstrably proven in the laboratory by scientists, and is not just a hypothesis…
          In short, I agree with Dr. Eades that eliminating refined carbs is one of the best things anyone could do to improve their health…but I disagree with him that deriving the majority of one’s calories from meat, fat, and dairy products is preferable to consuming a more varied diet that includes whole grains and legumes…Can anyone say atherosclerosis and fatty liver disease?

  139. Greg, why do you spend so much time and effort trying to convince us that we are partaking of an unhealthy diet? I’ve had a similar experience to Jon. In 2000, after losing 75 pounds on a low-carb, high-fat, adequate (not high) protein diet, my doctor was dumbfounded with the reversal of my health. You can see those details on my website under “About Me” at http://www.bodybybrand.com.The numbers don’t lie. My risk factors for heart disease are non-existent. I feel great. I don’t eat any grains, especially not wheat, it is not nutritious (this is why they fortify it). I eat poultry, fish and pork but mostly beef, along with eggs, bacon, butter, coconut oil, sour cream, nuts, seeds and some vegetables such as romaine lettuce, spinach, asparagus, broccoli, cauliflower, radishes, carrots, celery, onion, mushrooms, tomatoes, avocado (fruits, I know). I take a multi vitamin/mineral, D, fish oil, magnesium. I’m fine, thanks. Get a life. Read some stuff that doesn’t agree with how you think/believe now. Sounds like you’re still fairly young.

    1. I read your website. I have tried a low carb diet…pretty much the diet you describe for a period of not less than 4 months. It was ok in the beginning but it turned into an awful experience. I had palpitations, liver pain, felt angry and aggressive all the time, not to mention the constipation. When I switched to eating a more balanced diet (20-30% whole grains such as brown rice, oatmeal, millet, 25% vegetable, 20% meat, 10% legumes, and the rest in fruit in nuts with about one to tablespoons of oil/fat a day) I felt much better physically, and much more balanced emotionally. I have experienced la vida low carb, and I have experienced being a vegan. If I had to choose one, I would choose veganism, but I feel like I need to eat meat. At least you eat veggies, not like Jon. Stephen, the reality is that it’s possible to live a long and healthy life without eating animal products of any kind, but eating mostly animal products will not confer the same benefits. Check out the Seventh Day Adventists. Look at the diet of people living in the blue zones. None of them are low carb. At the end of the day, low carb diets may be a good transition for overweight and obese Americans (I am an American citizen, but they are the most unhealthy people in the world by many measures) who are used to stuffing themselves with greasy and refined foods, but they do not lead to health and longevity in the long run…Check out some of the links I posted earlier…you won’t be disappointed.

      1. Were you eating enough calories? The NUMBER ONE mistake people make when going low-carb is their calorie intake is far too low and they crash….HARD.
        Also, the constipation is easily corrected with a big bowl of leafy greens. Everybody I know who takes that advice is regular in the bathroom department.

  140. To: greg

  141. Dr. Eades, Would you please do what you can to end this most nefarious and continually obnoxious line of emails which could if it is read be
    misinterpreted. I find it a little like that old saying ‘tell a lie enough and the people will believe it’ very apt in this situation’, because it could also be misconstrued as you are giving people another choice for proper nutrition.

    1. I think people coming to this site pretty much know what my views are. I don’t mind having opposing views aired. People need to have information to make intelligent choices. If I have to embargo other opinions because I can’t argue my own position strongly enough, then I shouldn’t be blogging.

    1. Sigh. No, they’re not more up my alley. They are observational studies, which, as I’ve discussed many times on this blog, are of no value in determining causation. Yet the uninformed continue to rely on them to bolster various points of view. If such a study were to be published tomorrow showing meat eaters lived longer, I would say the same thing.
      In case you missed it, here is my commentary on observational studies.

    2. If we assume these studies are accurate (more accurate say than the latest NHANES which found zero difference) then what?
      Supposing vegetarians do live longer (and it doesn’t just seem longer).
      we all know you have to be bloody fit and strong to handle such a diet in the first place. Most people give up. (or maybe die when young, before they get to enter a study).
      So we have a set of people who choose this diet themselves, and then are filtered out by natural selection and the hardships of the diet so only the toughest remain. To survive on the diet they need to limit drinking, smoking, drugs and promiscuous sex. They tend to live a little longer, but they still don’t live as long as the world’s oldest people, who tend to be bacon eaters.

  142. So cheesburgers are better than salad?? Yayyy!!
    I love this:
    Bill Maher “There’s no money in healthy people. And there’s no money in dead people. The money is in the middle: people who are alive, sort of”
    Diet is a personal choice (very personal) and people get mad when you say their favorite foods like ice cream and cheeseburgers are bad. I personally love those foods, but they make me feel fat and sick. I don’t like to feel fat and sick. Vegetable and eating whole grains and juicing make me feel like a little kid…I have no aches pains or ailments. I know doctors hate that and if it wasn’t for the american over indulgence we wouldn’t have the economy we have today. So I thank those who are willing to give their own lives so I can live the american dream.

  143. The China Study is a load of crap.
    I have Chinese in-laws who emigrated from China. They’ve always eaten pork, chicken, dairy on a fairly regular basis. Every single one of them is trim and healthy. The vegan crowd is spreading misinformation about the Chinese diet, plain and simple. It’s as if they’ve never visited China or met a Chinese person.

  144. I’m actually thankful for the points you make about the China Study. My mother pushed this book on me for years and finally I succumbed and read it. Like most people who become believers, I passionately removed all meat and dairy from my diet (along with my husbands, epileptic son and healthy daughter). I became a passionate vegan, and along with my mom and sister, preached this to everyone we knew. I did it as an experiment to see how we would respond to the diet for about two years. My husband’s lipids improved and mine remained the same. My son resisted this and continued to eat meat and dairy every chance he could get (when he visited his friends, etc.) It was so unnatural to him. The problem was, over that year, I gained about 10 lbs, eating nothing but “healthy carbs, whole grains.” I ate very little protein and almost no fat. I was a triathlete and worked out sometimes hours a day but couldn’t figure out why I was gaining. My teenage daughter also gained weight. We both gravitated toward all those carbs-couldn’t get enough. I was starving all the time. After about 2 years, I decided to work back in some fish and a little bit of dairy in the form of yogurt. I continued to gain, now a total of almost 20 lbs. It was so frustrating, as I tried eating only the healthiest foods I could and working out like a mad woman. My belly was getting large for the first time in my life (40 yrs old at the time). Finally after going to several doctors for help, I was told I would not be able to lose the weight, it was my age, hormonal changes, etc. Even after cutting my calories to around 1000 per day on a mostly carb diet, I could NOT lose weight. My sister called me a liar, and accused me of cheating on the vegetarian lifestyle (she didn’t gain weight), but my father experienced similar weight gain and worse lipids on a vegan, then vegetarian diet. Beginning on January 2013, after googling reasons why I could be a vegetarian and still be fat, I found your website, as well as those of Dr. Peter Attia, Gary Taubes, etc. I have come full circle in my diet approach and cut out the carbs, refined sugar, wheat, and am now eating an animal, fat-based, low carb diet. It has been a long journey of frustration but I feel that there is a light at the end of the tunnel. I’m doing my own N=1 experiment to find what works for me and my body for optimal health. My daughter has followed and also lost some weight. My son is now free to eat the foods that he is naturally drawn to eat (he is not a sugar, or carb eater) and is seizure free. I’m down 15 lbs and hope to be down more by the end of the year. I feel great and feel armed with the data that helps me stay motivated. I hope this will be a lifelong change, but I’m open to making tweaks if necessary. I don’t believe in a one-size-fits-all diet. But I do think that everyone would benefit from cutting sugar in all forms and removing many of the starches that pervade our SAD. Thanks for your website, it is very motivational for me!

  145. Good thing you’re not trying to sell books! It might seem that you’re being biased. (Your comment about the Vegetarianism/Vegan references was really out there. I looked it up. You definitely implied something that wasn’t there.)

  146. How can you hope to be taken seriously in your criticism when you fail to mention any of the supporting arguments for Dr. Campbells conclusions by Dr. Caldwell Esselstyn. You talk a lot about obfuscation of the facts. Leaving out a major part of the book so as not to undermine your arguments is the greatest obfuscation of them all.

  147. Well-written article. I glad someone found the time to put in to the written word what I convey to the public to ease their fears. It truly is about eating a well-balanced diet and healthy lifestyle. I have dairy in my diet (not milk due to lactose defiency) but tolerate Greek yogurt, cheese and consume lean protein such as fish, chicken, turkey (not red meat) plus eat lots of fruits, vegetables and whole grains. I’m at a healthy body weight (108 -112) …plus have healthy blood pressure, cholesterol and blood glucose. Is plant-based diet healthy, of course, but if you want to consume but animal protein has it strong benefits as well…think Meditarreanean diet. Studies can always be interpreted according to one’s own bias. So it’s important to look at the validity of the studies by taking a closer at all the factors that may influence an outcome.

  148. I’m a 40-year-old woman and I’m eating much soya (milk, tofu, beans etc).
    Just two questions about soya:
    Where is the real evidence that this protein is harmless / that it is healthy and PARTICULARLY: What about phytoestrogenes? As Campbell showed us, that estrogenes are a risk-factor for breast-cancer?!

  149. Is it easier to maintain health on a whole grain plant based diet than any other diet?
    Is it easier to maintain the planet on a whole grain plant based diet?
    Most importantly people get all their vitamins (except B12 and D), antioxidants, and complex carbs only from plants.
    Are the only criticisms of The China Study about cancer?

  150. This is all so very confusing, frustrating, and entertaining- egos at work more than evidence. What is interesting here is NONE of this addresses an even larger issue- maybe not the direct argument, and boy do you people like to argue.
    It is called animal cruelty- yes, enter the animal advocate. If the debate on casein, animal protein or or or, is never solved with your scientific battle/debates then maybe your conscious will help you lean one way or another. The animal cruelty on our planet is at an all time high with no end in site unless we decide for ourselves, with much less need to weigh evidence- it’s what eases and guides your consciousness as a person inhabiting this planet. Animals consumed for their flesh or products makes them a commodity not a living sentient being. Not to mention the deteriorating state of our planet to grow and raise animals for ‘food’. So let your heart help you decide. Good luck with your ongoing debate.

  151. Your name says it all – Protein is where you make your living. You don’t want to believe that higher amounts of protein correlate with a lower risk of cancer. Are any of your protein folks using high protein to combat chemotherapy?

  152. Yes, Dr. Campbell’s study is an observation. However, what I note that you fail to confirm is how much of “mainstream” meat products are loaded with carcinogenic chemicals and antibiotics that are being sprayed all over factory cattle, pigs, etc. due to the very poor conditions. If you read Diet for a New America that quotes Dr. Campbell, you will quickly note that what John Robbins is highlighting is the impact of the factory farm on people’s health and the on the environment.
    I would also be interested to know who backs your commentary. Thanks.

  153. Campbell is fully aware of the correlation vs. causation issue. He dedicates subchapters to it at the beginning of The China Study.
    He clearly makes the point that correlation is a necessary BUT NOT sufficient condition for conclusive evidence.
    In fact, he adds that studies which investigate biological mechanisms AND explain the correlation are also necessary. He then dedicates sections of the remaining of the book to describe these.

  154. Hello! Active vegan here! 🙂
    This was a solid analysis of a not-so-solid study, and I appreciate that you took the time to discuss this issue in a thoughtful, scientific way. I am a gluten-free vegan, the only grain I will eat is white rice with no husk or germ-toxins, but I do eat a very significant proportion of my calories from carbohydrates. My daily macros are somewhere in the range of 75-15-10 for carbs, fat, and protein.
    I just had some bloodwork done, and I am at normal, heathy values for everything! My weight is stable, I have no chronic diseases, and overall I feel healthy. Can we all stop bashing other peoples ways of eating with a religious sense of “morality”, to correct someone who is “wrong” or “sinful” in their dietary habits? I DO think that health and veganism are correlated, as in someone who cares enough about their health to make such a dramatic change is also likely to take care of other regions of their health and well-being (such as exercise and emotional health). I also think that, while eating a reasonable, balanced, nutritional vegan diet is AS PHYSICALLY HEALTHY (NOT MORE, NOT LESS, will not cure all your chronic diseases overnight or make you grow shiny hair clear skin and a toned tush) as eating any other way, it is more emotionally healthy to eat foods that are from non-violent sources, processed without brutality. Just my two cents. 🙂

    1. You may be surprised to learn that I pretty much agree with you. Where we disagree is that a vegan way of dieting is just as healthful as any other way of eating. Many people seemingly do fine on vegan diets. I just don’t think it’s the optimal way to go. But that doesn’t meat it won’t work well for you and/or anyone else. Doing well, feeling fine, having shiny hair, no chronic diseases and the rest of your list can be the result of a number of different diets. In my view, the quest should be for what’s optimal, not just what makes one feel healthy.
      Just for grins, you should read Bastiat’s great essay. That Which is Seen, and That Which is Not Seen.
      I wish you the best. Thanks for keeping the discourse civil. I welcome you back anytime.

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